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H-FABP - The Diagnostic Value in MI and ACS

H-FABP is a highly accurate early ischemic marker11

 

H-FABP is a highly sensitive ischemic marker


McCann et al7

  • "Combining H-FABP and cTnT, provided a significant improvement in sensitivity for patients presenting within 4 and 12 hours"7
  • "Using the combination approach consistently improved the NPV, negative likelihood ratio, and the risk ratio"7
  • Multi-marker measurement of H-FABP and cTnI is 20% more sensitive than Troponin alone11

 

Multi-analyte Negative Predictive Value (NPV) enables early rule out of MI/ACS11

 

NPV in %

Time post pain 0-3h 3-6h 6-12h 12-24h
Individual markers

 

H-FABP 93 97 98 99
cTnI 92 95 97 99

2 marker combinations

 

H-FABP + cTnI 94 98

99

100

  • 98% NPV at 3-6 hours11
  • Enables earlier exclusion of MI11
  • More accurate risk stratification of low to medium risk chest pain patients11

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