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H-FABP - The Prognostic Value in MI and ACS

H-FABP presence equals increased risk


McCann CJ et al7

  • Elevated H-FABP is a significant predictor of death or MI within 1 year7
  • H-FABP provides additional prognostic information independent of Troponin T, ECG and clinical examination7

Increased H-FABP concentrations confers increased risk


Viswanathan K et al10

  • "Patients with H-FABP concentrations >6.48 µg/L had significantly increased risk of adverse events"10
  • "Among Troponin negative patients, the cut-off of 6.48 µg/L identified patients at very high risk of adverse outcomes independent of patient age and serum Creatinine" 10

H-FABP predicts mortality after ACS


Kilcullen N et al5

  • Raised concentrations of H-FABP are strongly predictive of mortality after ACS5
  • H-FABP allows identification of high risk patients across the full range of Troponin concentrations5
  • A negative test result for both Troponin I and H-FABP was associated with 0% mortality at 6 months5

H-FABP prognostic value across the ACS spectrum

 

 

Unstable Angina

NSTEMI

STEMI

H-FABP ( ≤ 5.8µg/l)

2.1% (2)

4.8% (9)

0% (0)

H-FABP (>5.8µg/l)

22.9% (19)

26.1% (189)

23.0% (77)

Adjusted HR

11.35

3.11

-*

95% CI

2.00-64.34

1.45-6.70

-*

p Value

0.006

0.004

-*

Kilcullen N et al5

  • "This demonstrated the additive value of H-FABP, particularly for ACS subtypes such as Unstable Angina, traditionally considered to be associated with low long-term risk"5

 

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