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H-FABP presence equals increased risk

McCann CJ et al7
- Elevated H-FABP is a significant predictor of death or MI within 1 year7
- H-FABP provides additional prognostic information independent of Troponin T, ECG and clinical examination7
Increased H-FABP concentrations confers increased risk

Viswanathan K et al10
- "Patients with H-FABP concentrations >6.48 µg/L had significantly increased risk of adverse events"10
- "Among Troponin negative patients, the cut-off of 6.48 µg/L identified patients at very high risk of adverse outcomes independent of patient age and serum Creatinine" 10
H-FABP predicts mortality after ACS

Kilcullen N et al5
- Raised concentrations of H-FABP are strongly predictive of mortality after ACS5
- H-FABP allows identification of high risk patients across the full range of Troponin concentrations5
- A negative test result for both Troponin I and H-FABP was associated with 0% mortality at 6 months5
H-FABP prognostic value across the ACS spectrum
|
Unstable Angina |
NSTEMI |
STEMI |
H-FABP ( ≤ 5.8µg/l) |
2.1% (2) |
4.8% (9) |
0% (0) |
H-FABP (>5.8µg/l) |
22.9% (19) |
26.1% (189) |
23.0% (77) |
Adjusted HR |
11.35 |
3.11 |
-* |
95% CI |
2.00-64.34 |
1.45-6.70 |
-* |
p Value |
0.006 |
0.004 |
-* |
Kilcullen N et al5
- "This demonstrated the additive value of H-FABP, particularly for ACS subtypes such as Unstable Angina, traditionally considered to be associated with low long-term risk"5
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