- H-FABP has a low normal plasma value
- Early release of H-FABP is due to its cytoplasmic location and low molecular weight
Biomarker |
Molecular Weight (Da) |
Initial elevation in blood |
H-FABP |
15,000 |
30 minutes |
Myoglobin |
17,800 |
1-3 hours |
Troponin I |
22,500 |
3-6 hours |
Troponin T |
33,000 |
3-6 hours |
CK-MB |
86,000 |
3-8 hours |
- H-FABP has an especially high potential as a sensitive biomarker for early diagnosis of AMI. H-FABP levels rise as early as 30 minutes after MI, peak at 6-8 hours, and return to normal within 24-30 hours6.
- H-FABP rapidly increases from base levels to clinical cut-off value, even faster than Myoglobin9.
- The characteristics of H-FABP release from injured myocardium closely resemble those of Myoglobin. However, because the cardiac tissue content of HFABP is much higher than that of Myoglobin, and the normal plasma value of H-FABP is much lower, H-FABP is a more sensitive marker of myocardial injury9.
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