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- Heart-type fatty acid binding protein (H-FABP) is a low molecular mass cytoplasmic protein (15 kD) that is abundantly expressed in human myocardial cells2
- H-FABP is also found in much lower concentrations in skeletal muscle, kidney and brain tissue2.
- H-FABP is involved in transporting fatty acids from cell membrane to mitochondria for oxidisation.
- H-FABP has an especially high potential as a sensitive biomarker for early diagnosis of AMI. H-FABP levels rise as early as 30 minutes after MI, peak at 6-8 hours, and return to normal within 24-30 hours6.
- The diagnostic potential of H-FABP was discovered as early as 1988 by Professor Jan Glatz, Maastricht3.
- Until recently, the effectiveness of H-FABP was hampered by the utilisation of non-specific polyclonal antibodies5. However, the conversion of assays to monoclonal antibodies has dramatically improved sensitivity & specificity, enabling the use of H-FABP in clinical practice.
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