Flexibility

Liquid and lyophilised reagents available to offer greater customer choice

Suitable for use on a range of analysers

Alanine Aminotransferase (ALT) Reagent is suitable to use on a number of third party analysers Including Abbott, Olympus, Cobas and Hitachi.

Stability

ALT is stable for up to 14 days when stored at +2 to +8°C

• IFCC method
• Available as liquid and lyophilised reagents
• Stable to for up to 14 days when stored at +2 to +8°C

Alanine Aminotransferase is one of the enzymes within the aminotransferases group and are among the most sensitive liver enzymes. The highest concentrations of the ALT enzyme can be in the liver, with decreasing concentrations found in the kidneys, heart, skeletal muscle, pancreas, spleen and lung tissue respectively.

ALT measurements are used in the diagnosis of hepatic damage and diseases including viral hepatitis and cirrhosis.

The normal concentration levels of ALT in the blood are low, however, when damaged, the liver releases more ALT into the blood causing the concentration levels to rise.  When diagnosing for hepatic damage, the root cause of the damage can be established, such as disease, drug, or injury

The ALT test not only allows for the diagnosis of liver disease but also allows for the diagnosis of the root cause of the disease

It is often tested in combination with the aspartate aminotransferase (AST) test as part of the hepatic panel with alanine aminotransferase levels being higher in most types of liver disease.  For more information on the validity and clinical utility of AST and ALT when assessing disease severity, please click here