HDL Cholesterol

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Key Benefits

There are several methods available for measurement of HDL Cholesterol

Including Direct Clearance and Phosphotungstic Acid

Exceptional correlation with standard methods

A correlation coefficient of r=0.99 for the Precipitation and Ultracentrifugation methods, was verified against the CDC reference method

Excellent stability

Stable for 30 days on board the analyser (Direct Clearance Method)

HDL Cholesterol-Direct Clearance Method

  • Direct Clearance Method
  • Liquid ready-to-use reagents
  • Stable to expiry when stored at 2-8°C
  • Measuring range 0.189 – 5.60 mmol/l
Cat NoSizeAnalyserEasy Read
Easy Fit
 
CH1383R1 3 x 2.5L
R2 1 x 2.5L
General Use--
CH2652R1 6 x 30ml
R2 3 x 20ml
General Use--
CH2655R1 6 x 78ml
R2 3 x 52ml
General Use--
CH2849240TSiemens Dimension
CH2861240T (AHDL)Siemens Dimension
CH3811R1 3 x 51ml
R2 3 x 20ml
RX Daytona/Imola
Hitachi 717/911/912/704/902


CH8033R1 4 x 38.2ml
R2 4 x 15.2ml
RX Suzuka
Abbott Architect
Hitachi 917/Mod P
Konelab 20i/30i/60i
Beckman Coulter AU Series








CH8311R1 4 x 20ml
R2 4 x 9ml
RX Daytona +/Monaco
Abbott Architect
Hitachi 917/Mod P
Konelab 20i/30i/60i
Beckman Coulter AU Series








Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Randox HDL Cholesterol Precipitant-Phosphotungstic Acid

  • AMP method
  • Liquid and lyophilised reagents available
  • Stable to expiry when stored at 15-25°C
  • Wide measuring range of 0.071-23.7 mmol/l
Cat NoSizeAnalyserEasy Read
Easy Fit
 
* CH203 is a precipitant product which can be used alongside the CHOD PAP assays
CH203 *4 x 80mlGeneral Use--

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the HDL Cholesterol assay used for?

High-density lipoproteins (HDL) are one of the major classes of plasma lipoproteins. They are composed of a number of heterogeneous particles, including cholesterol and vary with respect to size and content of lipid and Apolipoprotein. HDL serves to remove cholesterol from the peripheral cells to the liver, where the cholesterol is converted to bile acids and excreted into the intestine.

Accurate measurement of HDL-C is of vital importance when assessing patient risk from CHD. Direct measurement gives improved accuracy and reproducibility when compared to precipitation methods.

HDL is usually requested with other tests, either with cholesterol or as part of a lipid profile, including LDL and triglycerides. The combination of total cholesterol and HDL is very useful for screening for the risk of heart disease.

Patients at risk include:

  • Smokers
  • Men over 45 year and women over 55 years
  • Those with Hypertension (blood pressure 140/90 or higher or if taking medications for high blood pressure)
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  • Rhodes, P., et al. Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PloS ONE 2009, 4(10): e7393
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  • Wonnacott, K.E. et al. Dietary omega-3 and-6 polyunsaturated fatty acids affect the composition and development of sheep granulose cells, oocytes and embryos. Reproduction. 2010, 139(1): 57-69
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  • Kojic, Z., et al. Effect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbits. Physiol. Res. 2011, 60(1): S177-S184
  • Srinivasa, G., et al. Comparison between serum insulin levels and its resistance with biochemical, clinical and anthropometric parameters in South Indian children and adolescents. Ind. J. Biochem. 2011, 26(1): 22-27
  • Hossein-nezhad, A. et al. Circulating omentin-1 in obesity and metabolic syndrome status compared to control subjects. Endocrinol. Metabol. Syndrome 2012: S1:008 doi:10.4172/2161-1017.S1-008
  • Yahaya, N. et al. Type 2 diabetes with good glycemic control have improved insulin response and lower non-esterified fatty acid level after a meal challenge. Journal of Diabetes Mellitus 2012, 2(1): 1-7
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