Why are Neutralising Antibody tests important now?

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Why are Neutralising Antibody tests important now?

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27 October 2021- Why are Neutralising Antibody tests important now? 

Being prone to more frequent infections may mean that you have a weak immune system. With everything going on in the world, including COVID-19, this is important information that you need to know about yourself. As it stands, the pace of the vaccine booster rollout has slowed down and priority is given to people who are most vulnerable from developing a COVID-19 infection. This will offer those individuals the fullest protection against the virus this winter.  According to John Roberts, from the COVID-19 Actuaries Response Group, “At the start of the booster campaign, the health secretary Sajid Javid said: ‘We will protect the most vulnerable through the winter months’. But at the current rate it is going to be well through winter before we get through those first groups.”  This was stated on a BBC news article. (1)

This leads into the question that everybody is wondering…. Do we really need the booster vaccine? Infectious diseases expert, Professor Angus Dalgleish has commented during an interview on Good morning Britain that we should try another strategy.  A strategy where we should test people’s immunity first to see if they need the booster vaccine. He stated, “It should not be difficult for one test to see what your immune response to your last vaccine is or if you have had very bad COVID, have you got a good immune response and do you need the booster”. (2)

Laith Jamal Abu-Raddad, an infectious-disease epidemiologist at Weill Cornell Medicine—Qatar in Doha has also stated in an article from Nature that “Wasting resources on boosters for those who are already protected against severe disease does not really make too much sense,” (3)

The Randox SARS-CoV-2 Neutralising Antibody tests detects antibody levels post-vaccination to determine eligibility for a booster vaccination. These tests utilise patented biochip technology to detect neutralising antibodies to the Wuhan and Delta SARS-CoV-2 variants. There is a need for tests of this kind to provide an accurate estimate of immunity, monitor vaccine effectiveness and the frequency of post-vaccine breakthrough infections with variants of concern. Recent studies indicate that the delta variant is capable of re-infection even in fully vaccinated individuals and that a significant proportion of fully vaccinated individuals with breakthrough infections can transmit the virus to others.

The SARS-CoV-2 Neutralising Antibody tests are a quick and effective way to determine:

  • Longevity of immune response with response to post-vaccine infection, and variants of concern.
  • Population surveillance and testing of those at risk of sub-optimal vaccine response.
  • Measure antibody levels post-vaccination to determine eligibility for a booster vaccination.
  • Accurately detects antibodies that are capable of inhibiting virus replication and neutralizing the infectivity of the virus.

 

Want to know more?

For more information on SARS-CoV-2 Neutralising Antibody tests please visit the link below,

SARS-CoV-2 Neutralising Antibody Test | Randox Laboratories

Visit booking.randox.ie to book your COVID-19 antibody test today!

Alternatively contact us via email: marketing@randox.com

Sources linked-

  1. Covid: Is the pace of the vaccine booster rollout too slow? – BBC News
  2. ‘Don’t Panic’ Professors Questioned On The Rise In Covid Cases In England Sparking Concern | GMB – YouTube
  3. https://www.nature.com/articles/d41586-021-02158-6

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Randox and Collect+ join forces to boost accessibility of reduced-cost PCR and Lateral Flow tests

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25th October 2021: Randox and Collect+ join forces to boost accessibility of reduced-cost PCR and Lateral Flow tests

Today, Randox and Collect+ announce a new partnership that will provide even easier, nationwide access to low-cost COVID-19 testing. The partnership enables consumers to order a new reduced-cost PCR (£34.99) or lateral flow (£19.99) test online and then pick it up on the same day from participating shopping centres within the Collect+ network. This first of its kind partnership means people in the UK no longer need to wait for a home delivery or walk-in clinic access when ordering a COVID-19 test.

With an initial 29 locations already open, this collaboration plans to expand to more than 100 Collect+ locations in the coming weeks, and hopes to go further to utilise even more of the Collect+ network over the medium to longer term. Randox’s collaboration with Collect+ has not only simplified the logistics process but has sought to help support their retailer partners and provide another vital service at the heart of local communities.

In recognition of changes to travel guidelines for England, which state that from 24th October, fully vaccinated passengers from non-red list countries can take a lateral flow test for their day-two post-arrival checks, Randox now offers home testing kits as both PCR and lateral flow, to aid pre-departure testing and any current and future day 2 requirements. PCR and lateral flow tests are available at the newly reduced prices of £34.99 and £19.99  respectively when using Collect+ click and collect.

Philip Robinson, VP Sales at Randox said: “As guidelines change and the country continues to open up, Randox is able to support any travel testing requirements by utilising our extensive diagnostics experience and logistics network, and offering value for money for both PCR and lateral flow tests that can be collected at the customer’s convenience thanks to our new partnership with the Collect + service from PayPoint.

 “Our significant investment in capacity expansion and in logistics solutions such as Collect + click and collect sites that further simplify the process of ordering COVID-19 tests, have allowed us to make ongoing price reductions, demonstrating our commitment to helping people live their lives as easily and normally as possible.”

Nick Williams, Head of Strategic Partners & Product, Collect+ said:This is an exciting and important partnership for Collect+, which has always had consumer convenience and accessibility at the very heart of its operations. Randox has been instrumental in making COVID-19 tests easily available to people around the UK and this collaboration will see that country wide impact become even more meaningful.”

As Randox remains amongst the very largest COVID-19 laboratories in the UK and Europe and to date has processed almost 20 million tests, facilitated by drive-thru services, in-person clinics and home delivery options, the introduction of Collect+ locations further diversifies the efforts made by the company to make testing more accessible.

The number of Randox shopping centres with Randox Collect + locations now totals 29, including but not limited to Liverpool ONE, Waterloo Station, Brent Cross London, and Festival Place Basingstoke.

Neil Churchill, Centre Director, Festival Place Shopping Centre, commented:

“The Randox click and collect service is a good illustration of Festival Place’s growing position as an all-day destination, offering a variety of services to complement the traditional retail offer. Our Guest Services team have noted an increase in visitors, from all across Europe, passing through Festival Place to collect the Randox kits required for their travel. Customers appreciate the option to pick up their kits close to home while able to do their shopping at the same time.”

 

For further information on our new Click and Collect service please click here.

For press enquiries please contact Amy Millar, Randox Public Relations Team Leader; amy.millar@randox.com or 028 9442 2413

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23rd October 2021: 20 million tests across the National Testing Programme and testing for travel

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23RD OCTOBER 2021: THE 20 MILLION MILESTONE 

We are pleased to let you know that on 23rd October 2021, Randox processed its 20 millionth across the UK COVID-19 National Testing Programme and testing for international travel.

That’s an incredible 20 million samples processed by our dedicated and talented staff.

Our staff are our best asset and have risen to the challenge this pandemic has created.

They have worked hard and flexibly, been creative and innovative, and pulled together as a team to make an impact in the fight against COVID-19.

We are very proud of their efforts and teamwork.

Let us once again say thank you to each and every member of Team Randox, for the efforts they have made.

What we do at Randox remains vital to the national and global management of COVID-19 and our work is making a real and positive difference.

We continue to work hard and improve, for the sake of our family, friends and communities.

For further information please email randoxpr@randox.com

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Randox listed on Gov.uk as provider of Day 2 Lateral Flow COVID tests

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22nd October 2021: Randox listed on Gov.uk as provider of Day 2 Lateral Flow COVID tests

Following changes to government travel guidance, lateral flow (antigen) tests will be the Day 2 requirement for any fully vaccinated passengers arriving into England, from 24th October.  This change applies only to fully vaccinated international travellers and most under 18s arriving into England from non-red list countries, and will replace the previous PCR testing requirement.

This change will come into effect for anyone returning into England, following the half-term break and tests can be completed on or before day two of their arrival.

Randox is listed on Gov.uk as a provider of Day 2 Lateral Flow COVID tests.

Randox offers multiple lateral flow testing solutions, including the new Randox CertiFly rapid antigen test, which will allow you to complete your Day 2 test in the comfort of your own home from only £19.99.

The Randox CertiFly Lateral Flow test is designed to simplify foreign travel for passengers and facilitate the efficient transfer of secure and verified information through an easy to use mobile app.

Available for free through the App Store and coming soon on Google Play, the app securely identifies customers and processes testing results within 3 hours.

To order a Lateral Flow Home Testing Kit visit https://covid.randox.com/day-2-test-at-home/

If your preference is to take your Day 2 test on arrival at the airport then you have the option of visiting one of our many travel centres conveniently located across the UK.

From £35 you can organise for a Sample Collection Officer to take your swab at clinics including Manchester Airport, Heathrow Airport, Stansted Airport, East Midlands Airport, Liverpool ONE, and Waterloo Station London.

To book an in-clinic Day 2 Lateral Flow appointment visit https://covid.randox.com/day-2-test-in-clinic/

Background to Government changes

Eligible fully vaccinated arrivals and those with an approved vaccine from non-red countries will be able to replace the test taken as soon as possible on arrival, referred to as the Day 2 PCR test, with a self-administered lateral flow device (“LFD”). Arrivals must have had a complete course of a recognised vaccine at least 14 days before arriving in England. They will not be required to take a Pre-Departure Test or a Day 8 test.

Day 2 Lateral Flow

Passengers who do not meet the “eligible traveller” criteria will still have to take a pre-departure test, a Day 2 and Day 8 PCR test and self-isolate for 10 days upon their return from a non-red list country. Test to Release will remain an option for unvaccinated passengers who wish to shorten their isolation period.

How will the new lateral flow system work?

Passengers will be required to take a photograph of their completed lateral flow test alongside their booking reference number which Randox will provide via email on receipt of order. Randox will then verify the result of your sample. Passengers will still be required to complete a passenger locator form to return to England.

Anyone who tests positive will be required to self-isolate and take a confirmatory PCR test. The government have confirmed that anyone who has previously purchased a Randox PCR test will not need to buy another lateral flow (antigen) test.

With proven testing capability and well-established logistics and customer support services, Randox is strongly placed to allow all travellers to the UK to complete their antigen test with ease  – offering same day results up to 11.59pm.

 

For further information on our Day 2 Lateral Flow testing please click here.

To read more on official UK government announcement please click here.

For customer enquiries please contact our Customer Support team on 028 9434 3005.

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Randox receives UKAS ISO 17025 Accreditation for testing of SARS-CoV-2 (COVID-19)

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Randox receives UKAS ISO 17025 Accreditation for testing of SARS-CoV-2 (COVID-19)

Randox Laboratories has today confirmed its UKAS ISO 17025 accreditation for the detection of the SARS-CoV-2 virus (COVID-19), granted on 7th October 2021.

UKAS is the National Accreditation Body for the United Kingdom and is appointed by government to assess and accredit organisations that provide testing services. Given the unprecedented requirement for nationwide testing over the past two years, the need for the public to have confidence in testing remains more important than ever.

Randox has been at the forefront of COVID-19 testing since the outset of the pandemic, is amongst the very largest COVID-19 laboratories in the UK and Europe, and to date has processed almost 20 million tests.

Today this final UKAS documentation confirms that Randox has continuously met all ongoing Government and UKAS requirements and submission deadlines, to remain fully active as a national COVID-19 testing provider, and listed on the Gov.uk website.

Randox, with almost 40 years of diagnostics experience, and multiple UKAS accreditations for a range of testing methods, is well placed to support the testing requirements associated with international travel.

 

To order a Randox home test kit visit covid.randox.com 

For any enquiries on our Covid testing services please contact the Randox Covid Customer Support team on +44 (0) 28 9434 3005.

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Health Minister Robin Swann visits Randox COVID testing laboratories

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20th October 2021: Health Minister Robin Swann visits Randox COVID testing laboratories

Health Minister Robin Swann has today thanked local staff for their ongoing role in COVID-19 testing while visiting Randox Laboratories.

During his visit to the testing facility at Randox Science Park on the outskirts of Antrim, the Health Minister heard how the company significantly increased its testing capacity since the beginning of the pandemic.

Following a tour of the facility, Minister Swann, said: “Randox continues to play an important ongoing role in the fight against COVID-19 as part of the National Testing Programme and has enabled thousands of people in Northern Ireland to get tested quickly.

“There is no doubt, that we are in a very fortunate position in Northern Ireland to have companies like Randox. We have seen how the company and its highly skilled and expert workforce have been able to innovate and advance its testing capabilities to greatly support the pandemic. I want to personally thank the staff at Randox for all they have done in helping to keep people safe.”

Minister Swann added: We are continuing to see a high number of positive cases each day in Northern Ireland which is concerning. Therefore I would again remind people of the importance of getting tested should they develop symptoms. Alongside vaccination and contact tracing, COVID-19 testing remains one of the main pillars of protection against this virus. Please do the right thing.”

Dr Peter FitzGerald, Randox Managing Director said:

“We are delighted to welcome Minister Swann to our COVID testing laboratories at the Randox Science Park in Antrim, to witness first-hand the incredible efforts of our hard-working staff, who have been at the forefront of COVID-19 testing since the outset of the pandemic and as such have played a vital role in the global fight against coronavirus.

“Thanks to their ongoing commitment to serve our communities in these difficult times, Randox remains amongst the very largest COVID-19 laboratories in the UK and Europe, and to date has processed almost 20 million tests for the UK National Testing Programme and testing for international travel.

“Randox have built on 40 years of diagnostic experience, and extensive R&D, to provide our extensive COVID-19 testing capabilities and we will continue to support the community and the needs of travellers for as long as that is required. Thereafter we know that diagnostics have a key role in future healthcare, to both prevent disease and optimise its treatment, and will refocus our efforts to that end.”

Since March 2020, Randox has invested a total of £150 million in the development of new innovations in testing technology and in the building and equipping of world-class testing laboratories, sample collection clinics, and associated logistics networks. The company has also grown its workforce by more than 850, and continues to recruit across science, manufacturing and customer support.

For further information please contact Amy Millar, Randox Public Relations Team Leader; amy.millar@randox.com or 028 9442 2413

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We Are Randox | Randox IT is shortlisted in the Belfast Telegraph IT Awards 2021

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19 October 2021: Randox IT Team is shortlisted in the Belfast Telegraph IT Awards 2021

Congratulations to the Randox IT department who have been shortlisted in four categories at the Belfast Telegraph IT Awards 2021.

The event from the Belfast-based media outlet, is set to be a showcase of the finest that the Northern Ireland IT industry has to offer with both IT agencies and in-house IT teams vying for the chance to be crowned among the best their respective fields.

Randox IT have been shortlisted for Digital Project of the Year, IT Team of the Year, IT Project Team of the Year, and Covid Response for their work on the development of IT systems required for nationwide COVID testing, playing a critical role in the fight against COVID-19.

See an overview of their applications below.

In early 2020 Randox, the largest diagnostics company from the UK, recognised the threat from COVID-19 and based on almost 40 years of experience, developed a test to identify the virus in a greatly accelerated timeframe of just two weeks.

Faced with unprecedented demand for testing to curb the spread of the virus, the company stepped up to support the UK Government’s National COVID-19 Testing Programme without hesitation.

Armed with world-leading testing technology and expertise, the next step for Randox was to scale its capacity and infrastructure.

Growing from an initial testing capacity of just 150 samples on the first day of COVID testing in March 2020, to now a capacity of 500,000 COVID samples per day, Randox has to date tested almost 20 million samples across the National Testing Programme and private testing for international travel.

These accomplishments would not have been possible without the Randox IT team, who responded quickly in an ever-evolving situation and introduced a full end-to-end testing process inclusive of logistics, sample registration, accessioning and results reporting, for tens of thousands of daily tests.

The development of platforms such as an online sample kit registration portal, intelligent robotics automation, and an informatic lab workflow management system, all designed and developed entirely in-house, showcases the knowledge, expertise, responsiveness and overall capability within Randox IT.

Examples of innovative systems developed in-house by the Randox IT team include but are not limited to;

  • Online sample collection kit registration portal
  • Robust accessioning platform for sample receipt and chain of custody
  • End-to-end digital and informatic laboratory workflow management solution
  • Robotics for intelligent process automation
  • Fully automated result communication system
  • Intelligent data management
  • Diagnostic algorithm development

Each of these innovative and re-deployable platforms has been scaled across a number of different testing services. Initially intended for Randox’s new 80,000 sqft of molecular laboratory space at the company’s headquarters in Antrim, the systems are also in use across newly built adaptive labs in Manchester and London, in mobile testing vans at key airport locations, and in a number of walk-through and drive-through testing clinics across the UK and Ireland.

The improvements in IT automation, robotics and software capabilities, have enabled Randox to upscale its testing capability like no other – growing the company to be amongst the largest COVID-19 testing laboratories in Europe.

The finals for the Belfast Telegraph IT Awards 2021 will take place on Friday 5th November 2021 in The Mac, Belfast and all finalists can be viewed here.

Good luck to the Randox IT department!

 

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Randox launch authentication app for Day 2 Lateral Flow tests for vaccinated international arrival

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18th October 2021: Randox launch authentication app for Day 2 Lateral Flow tests for vaccinated international arrivals

Randox, the UK’s largest diagnostics company, today announces that it is launching the Randox CertiFly App, a mobile application designed to securely process and certify results for both pre departure and Day 2 lateral flow tests – the latter a requirement for vaccinated international arrivals in the UK from 24th October.

The app, which applies ID verification technology, is designed to simplify foreign travel and facilitate the efficient transfer of secure and verified information through three simple steps:

Step 1 – Download the Randox CertiFly App and scan your passport to register

Step 2 – Collect your sample using a Randox CertiFly lateral flow testing kit

Step 3 – Scan your result using the app and receive certificate in app and by email

The app, which is solely for use with Randox Certifly lateral flow tests, is free to download.  The lateral flow tests, which are ordered from Randox and cost as little as £20,  are then used in combination with the app to capture the individual’s ID and securely upload the test result.  The identity of users will be validated by scanning passports into the system, with future versions of the app featuring facial recognition software to further increase security.

Available in just 15 minutes, test results are processed using Randox CertiFly’s AI software, before being confirmed manually by a healthcare professional. As applicable, a Day 2 or fit-to-fly certificate will then be issued to the user and stored in the app for easy access.

Each Randox CertiFly lateral flow testing kit has a unique single-use QR code that can be registered with the app. Testing kits, which can be purchased from the Randox Health website, include swab, extraction buffer tube, waste bag, tube holder, package insert and test cassette. The app is available now for iOS and Android devices.

Commenting on the announcement, Dr Peter FitzGerald CBE, Managing Director at Randox, said:

“COVID-19 has severely impacted the way that we travel but, thankfully, testing technology has been able to help the world open up again. At Randox, we are proud to have been at the heart of UK testing and we are continuously looking at ways to make improvements for our customers. Randox has been helping millions of passengers travel safely since the onset of the pandemic by providing innovative testing solutions, like the Randox CertiFly app, that fulfil testing requirements for those who need to travel, whilst keeping costs as low as possible.”

randox certifly £20

Alex Rusak, Randox VP Business Development, said:

“With Day 2 lateral flow test results a requirement for vaccinated international arrivals in the UK from 24th October, we are pleased to launch our first lateral flow test certification app. The features of the app maximise security and allow the efficient flow of accurate and secure information to provide customers with a verified results certificate, without the need for time-consuming and costly video consultations. With the ability to process more than 100,000 certificates in 24h, the Randox CertiFly App rapidly provides validated test results, with the ultimate goal of making sure that travel is accessible, affordable, and importantly, safe.”

Fintan O’Rourke, Head Of Global partnerships at CertiFly, added:

“We are encouraged to see testing policy adapt to make international travelling easier and we believe that it’s crucial for technology to adapt alongside this to keep the country as safe as possible. Technology plays a vital role in ensuring the integrity of COVID-19 testing and that’s why CertiFly has developed an app with Randox to reduce the risks associated with fraudulent testing. We have built in the same verification technology that banks use to eliminate identity fraud and a two-step validation process for test results, with AI analysis followed by verification from a healthcare professional. As restrictions evolve, is it important to maintain rigorous testing standards in support of the UK’s fight against COVID-19, and we are proud to be part of this.”

The Randox Certifly App is available to download for iOS and Android devices following purchase of a lateral flow test at covid.randox.com

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Randox strengthen partnership with Sheffield United by agreeing to become naming right partner of the widely-acclaimed Sheffield United Academy

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08th October 2021 – Randox strengthen partnership with Sheffield United by agreeing to become naming right partner of the widely-acclaimed Sheffield United Academy

Sheffield United have today announced a further strengthening of their principal partnership with Randox. The healthcare giants have agreed to become naming right partners of the widely-acclaimed Sheffield United Academy.

Located at Shirecliffe, it is the base of the men’s, women’s and academy teams. The facility, since its opening its doors in the early 2000s, has seen the likes of Kyle Walker, Harry Maguire, David Brooks, Dominic Calvert-Lewin and Aaron Ramsdale all progress through the academy ranks.

Established in 1982 in Northern Ireland, Randox is the largest healthcare diagnostics company from the UK and Ireland. In 2019 Randox manufactured over four billion tests and operated in over 145 countries. The company employs more than 2,500 staff, including more than 450 research scientists and engineers, with key facilities located in Co. Antrim and Co. Donegal.

Randox Managing Director Dr Peter FitzGerald CBE said: “We are very excited for the opportunity to extend our partnership by aligning Randox with the Sheffield United Academy. With almost 40 years of experience in the manufacture of world-leading medical diagnostics and comprehensive health check and sports science services, Randox is well positioned to assist in the development of the health, wellbeing and performance of these elite athletes. We look forward to working with the Academy and to lending our expertise to make further developments in cutting-edge sports science.”

United’s head of commercial, Paul Reeves, said: “This is a significant further investment from Randox and a long-term commitment to our next generation of players, both male and female. The academy plays an integral part within the club and it goes without question the rising importance of developing players of all ages to continue to compete on a global scale. We would like to thank Dr FitzGerald and his colleagues for their valued contribution.”

Paul added; “The newly-named Randox Health Academy has some exciting prospects on the horizon with the likes of Daniel Jebbison, Femi Seriki and Iliman Ndiaye all making their Premier League debuts at the end of the 20/21 season.”

Visit randoxhealth.com to find out more about their ground-breaking R&D, advanced health checks, and rapid COVID travel tests.

For press enquiries please contact Amy Millar in the Randox PR team on amy.millar@randox.com or 028 9442 2413

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Rheumatoid Factor: The Most Remarkable Autoantibody in Rheumatoid Arthritis

Rheumatoid Factor:

The Most Remarkable Autoantibody in Rheumatoid Arthritis

Celebrating World Arthritis Day (WAD)

Rheumatoid Factor: The Most Remarkable Autoantibody in Rheumatoid Arthritis

World Arthritis Day (WAD) is celebrated on 12th October to help raise global awareness of the existence and impact of rheumatic and musculoskeletal diseases (RMDs). It is estimated that over one-hundred million people are currently undiagnosed impacting their quality of life and participation in society – including their ability to work and lead a normal life. As a result this increases dependency on state welfare, the healthcare system and the required support from their family and friends.

The European League Against Rheumatism (EULAR) launched the ‘Don’t Delay, Connect Today’ campaign focusing on the importance of early diagnosis and access to care.

Randox Reagents fully supports the importance of early diagnosis – to aid in the early implementation of effective treatment plans, aiding in improved health outcomes – it’s the ethos of our business. This blog delves deeper into rheumatoid factor (RF), the most remarkable autoantibody in rheumatoid arthritis.

Pathobiology of Rheumatoid Arthritis (RA)

The pathophysiology of RA involves various signaling pathways and immune modulators (effector cells and cytokines) as indicated in figure 1. Joint destruction is caused by the intricate interactions of immune modulators, beginning at the synovial membrane and encompassing most IA structures, with synovitis caused by both or individually, the local activation or influx of mononuclear cells, including: B cells, T cells, dendritic cells, plasma cells, mast cells and macrophages. Consequently, “the synovial lining becomes hyperplastic, and the synovial membrane expands and forms villi”. The neutrophils, chondrocytes and synoviocytes secrete enzymes that degrades the cartilage in the joint whereas the osteoclast-rich area of the synovial membrane destroys the bone 4.

Rheumatoid arthritis (RA), “the most common systemic inflammatory autoimmune disease” affecting 1% of the global population, is characterised by fatigue, synovial joint pain, stiffness, swelling and destruction, with severe symptoms resulting in disability. Whilst the exact cause of RA is unknown, it is believed that genetic and environmental factors play a role in triggering the disease 2, 3.  Differences in the human leukocyte antigen (HLA)-DRB1 alleles (proteins with a critical role in the immune system) have been identified as a genetic variant for RA, observed in >80% of patients, particularly in those testing positive for RF. Moreover, those with variations in the HLA-DRB1 who smoke, increase their risk of RA. As RA is more common in women (2-fold increased risk in women compared to men), hormonal influences are an area of active research, however, an inverse correlation with breastfeeding has been identified. Women who breastfeed for >13 months aids in reducing the risk of RA compared to women who have never breastfed 3, 4.

Figure 1: Schematic view of (a) a normal joint and (b) a joint affected by RA 4 

Clinical Significance of Rheumatoid Factor (RF)

Interestingly, elevated levels of RF have been observed in other autoimmune conditions such as Sjögren syndrome and systemic lupus erythematosus (SLE) as well as non-autoimmune conditions including old age and chronic infections. Despite this, RF in RA patients can be distinguished from RF in healthy individuals. RF in RA patients displays affinity maturation whereas RF in healthy individuals has low affinity and are polyreactive 2.

RF is a class of immunoglobulin (Ig) autoantibodies that are directed against the fragment crystallizable region (Fc region), the tail region of the IgG antibody. In RA, RF are produced by the B cells present in lymphoid follicles and the germinal center(GC)-like structures that mature in inflamed synovium. Most RF are IgM antibodies, but may also be IgG or IgA isoforms. IgM RF are detected in 60% to 80% of RA patients. “RF testing in RA patients has a sensitivity of 60% to 90% and a specificity of 85%” (5). RF is a highly valuable biomarker in RA 5, 2.

Key Features of the Randox Rheumatoid Factor Assay

The Randox automated latex enhanced immunoturbidimetric rheumatoid factor assay provides an accurate assessment of RF titre as the Randox rheumatoid factor calibrator is standardised against the primary WHO material, 1st British Standard 64/2. With a wide measuring range of 6.72 – 104lU/ml for the comfortable detection of clinically important results, the Randox RF assay is available in a liquid ready-to-use format for the comfortable detection of clinically important results. The Randox rheumatoid factor assay does not suffer from interference from C1q complement and is stable until expiry date. With dedicated calibrator and controls for a complete testing package, Randox offer applications, detailing instrument-specific settings for the convenient use of the Randox rheumatoid factor assay on a wide range of clinical chemistry analysers.

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  • Signing up to our mailing list is quick and easy. We do not wish to send you any spam or junk email, therefore, you can expect to receive mailshots including new product launches and updates, market trends, attendance at key industry events and much more. Randox Laboratories promise never to sell your data and we will keep all your details, safe and secure. Read more in our Privacy Policy.
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