Key Benefits the Randox Alpha-1-Acid Glycoprotein reagent
Wide measuring range
The healthy range of alpha-1-acid glycoprotein is 50 – 120 mg/dl. The Randox Alpha-1-Glycoprotein reagent can comfortably detect levels outside of this range with a measuring range of 24.6 – 453 mg/dl.
Stable to expiry when stored at +2 to + 8°C
Excellent correlation with standard methods
The Randox methodology was compared against other commercially available methods and the Randox Alpha-1-Glycoprotein assay showed a correlation coefficient of r=0.99
Other Features of the Alpha-1-Acid Glycoprotein reagent
- Liquid ready-to-use reagents
- Stable to expiry when stored at +2 to +8°C
- Measuring range 24.6 – 453 mg/dl
What is Alpha-I-Acid Glycoprotein assay used for?
What is Alpha-1-Acid Glycoprotein?
Alpha-1-Acid Glycoprotein (AAG), also known as Orosomucoid, is an acute phase protein found in human serum. AAG is mainly biosynthesised in the liver and is secreted into the blood. The heart, stomach and lungs also have the ability to synthesise and secrete AGP. The function of AAG includes; the inhibition of platelet aggression, modulation of lymphocyte proliferation, and is to act as a carrier of basic drugs, steroids, and protease inhibitors. AAG concentration levels can increase in response to infectious and inflammatory conditions, however concentration levels can decrease in response to nephrotic syndrome, pregnancy or oestrogen therapy.
What is the Alpha-1-Acid Glycoprotein assay used for?
Alpha-1-Acid Glycoprotein is primarily used for monitoring tumor recurrence. It is a useful protein to monitor alongside Haptoglobin, where levels of both, levels of AAG and Haptoglobin should rise simultaneously. For more information on Haptoglobin, please click here [external link]. Normalising the concentration levels of AAG during antineoplastic therapy correlates with a significantly prolonged relapse-free survival in lung cancer patients.
The Randox Alpha-1-Glycoprotein immunoturbidimetric assay is used for the quantitative in vitro determination of AAG in human serum and plasma.