Key Benefits of Randox Alpha-1-Antitrypsin (AAT) reagent
Wide measuring range
The healthy range of alpha-1-antitrypsin is 150 – 350 mg/dl. The Randox Alpha-1-Antitrypsin reagent can comfortably detect levels outside of this range with a measuring range of 38.7 – 660 mg/dl
Stable to expiry when stored at +2 to +8⁰C
Excellent correlation with standard methods
The Randox methodology was compared against other commercially available methods and the Randox Alpha-1-Antitrypsin assay showed a correlation coefficient of r=0.99
Other Features of the Alpha-1-Antitrypsin (AAT) reagent
- Immunoturbidimetric method
- Liquid ready-to-use reagents
- Stable to expiry when stored at +2 to +8⁰C
- Measuring range 38.7 – 660 mg/dl
What is Alpha-I-Antitrypsin (AAT) assay used for?
What is Alpha-1-Antitrypsin (AAT)?
Alpha-1 antitrypsin is a glycoprotein which is mainly produced in the liver. It is a serine proteinase inhibitor. Most alpha-1 antitrypsin in the body is produced by the liver. The primary function of AAT is to protect the elastin fibres of the lungs by inhibiting neutrophil elastase.
What is the alpha-1-antitrypsin (AAT) assay used for?
AAT is a genetic systematic deficiency as a result of genetic mutations which can result in chronic lung disease such as emphysema, which is also known as ‘inherited emphysema’ or ‘genetic COPD’, and can also result in liver failure. Alpha-1-Antitrypsin deficiency (AATD) is the progressive destruction of the alveoli and small airway structures. This formed the basis of the protease / antiprotease imbalance theory. For more information on the protease / antiprotease theory, please click here [external link]. Increased levels of AATcan occur due to trauma, pregnancy, administration of oestrogens or typhoid vaccine.
The Randox AAT assay is used for the immunoturbidimetric in vitro determination of AAT in human serum and plasma.