Key Benefits of the Antithrombin III (AT III) Reagent
The Randox antithrombin III methodology has been compared with other commercially available methods and the Randox AT III reagent showed an excellent correlation coefficient of 1.00
Dedicated coagulation controls and calibrators available
The Randox AT III reagent has been specially designed for accurate calibration and quality control
The Randox AT III reagent has a precision of less than 4% CV so results are consistent
Other Features of the Randox Antithrombin III (AT III) Reagent
- Photo-optical method
- Stable for 2 months when stored at +2 to +8°C (Thrombin reagent and Substrate)
- Minimum detectable concentration determined as 30%, linear up to 130% Antithrombin III activity
What is Antithrombin III (AT III) assay used for?
What is Antithrombin III (AT III)?
Antithrombin III is a small glycoprotein produced in the liver that inhibits the activity of plasma serine proteases. The dominant form of Antithrombin is α-Antithrombin which can be found in blood plasma.
An important function of AT III is the inhibition of thrombin activity. Normally the rate of thrombin inhibition by Antithrombin III is slow (progressive Antithrombin activity). However, the rate of inhibition can be enhanced several thousand-fold in the presence of anticoagulant Heparin (Heparin cofactor activity). Antithrombin also affects other serine proteases of the coagulation cascade including Factor Xa, Factor XIA and Factor IXA.
What is the Antithrombin III (AT III) assay used for?
Antithrombin deficiency can arise for a few reasons, however congenital AT deficiency is the most clinically significant of the inherited thrombophilias resulting in thrombosis in the majority of those affected. For more information on thrombophilia, please click here [external link]. The main challenges faced whilst managing these types of patients is preventing potentially life-threatening thrombosis, while minimising the equally significant risk of haemorrhage associated with long-term anticoagulation. Therefore, the Randox Antithrombin III reagent is used for the quantitative in vitro determination of Antithrombin III (AT III) in human plasma.