Reagent | Beta 2 Microglobulin
Key Benefits of the Beta-2 Microglobulin reagent
Wide measuring range
The healthy range of beta-2 microglobulin is 0.9 – 3.0 mg/l. The Randox Beta-2 Microglobulin reagent can comfortably detect levels outside of this range with a measuring range of 0.476 – 20.9 mg/l.
Stable until expiry date when stored at +2 to +8⁰C
Liquid ready-to-use reagents
The Randox Beta-2 Microglobulin reagent comes in a liquid format which is more convenient as the reagent does not need to be reconstituted which aids in reducing the risk of errors occurring
Other features of the Beta-2 Microglobulin reagent
- Liquid ready-to-use reagents
- Stable to expiry when stored at +2 to +8⁰C
- Measuring range 0.476 – 20.9 mg/l
What is the Beta-2 Microglobulin assay used for?
What is beta-2 microglobulin?
Located on the surface of most cells, especially nucleated cells, are large surface proteins called Class I antigens which are made up of a heavy chain and a light chain. The heavy chain is produced by multiple genes and the light chain is chemically bound to it. This light chain is the beta-2 microglobulin. Class I antigens are mostly expressed on lymphoid cells and expressed less on the lungs, kidney and liver and are sparsely expressed on skeletal muscle and the brain. Beta-2 microglobulin is shed by the cells which becomes detectable in the bloodstream under normal conditions.
What is the beta-2 microglobulin assay used for?
Elevated concentration levels of beta-2 microglobulin is attributed to diseases with a high cell turnover. It is a powerful prognosis factor for multiple myeloma, a type of bone marrow cancer. It is also used to detect chronic lymphocytic leukemia and some types of lymphomas. For more information on tumor markers, please click here [external link].
Low concentration levels of beta-2 microglobulin in serum and high concentration levels is urine is attributed to renal tubular disease. This is particularly important during the onset on diabetes as the kidneys grow larger and the glomerular filtration rate (GFR) becomes supranormal which are risk factors for the development of diabetic nephropathy in later life. For more information on renal function in diabetic disease model, please click here [external link].
The Randox Beta-2 Microglobulin assay is used as a white blood cell tumor marker as well as a biomarker for renal disease.