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Female Bladder Cancer Array

Improved Risk Stratification of Haematuria Patients

Identify Individuals at Greatest Risk of Bladder Cancer

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    Improve management of patients with haematuria, reduce unnecessary investigations and refer those at greatest risk of bladder cancer for urgent cystoscopy.
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    Simultaneous detection of four novel biomarkers from a single urine sample to determine an individuals biomarker risk score.
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    Determine overall bladder cancer risk by combining biomarker risk scores with clinical risk scores generated using our complex algorithms.

There is an urgent critical need for additional evidence-based risk stratification models to inform triage and/or management decisions for patients presenting with haematuria. Current diagnostic methods such as cystoscopy  and cytology are invasive, carry risks for the patient and have several limitations.

In addition, existing biomarkers lack specificity and may fail to differentiate between all possible causes of haematuria. Utilising patented biochip technology, the female bladder cancer array will allow accurate risk stratification of female patients presenting with haematuria. Bladder cancer is the 8th most common cancer in females, although more common in males mortality is twice as high in females highlighting the need for alternative diagnostic methods.

Clinical patient pathway using the Randox Biochip Technology to reduce cystoscopy burden allowing patients at greatest risk to be triaged for urgent cystoscopy.
Clinical patient pathway using the Randox Biochip Technology to reduce cystoscopy burden allowing patients at greatest risk to be triaged for urgent cystoscopy.

Biomarkers Tested 

  • IL12p70
  • IL13
  • Midkine
  • Bladder Tumor Antigen (BTA)

Interleukin-12 p70 (IL12p70) is a disulphide linked heterodimeric cytokine which regulates inflammation by linking innate and adaptive immune responses and potent inducer of antitumor immunity.  

Interleukin-13 (IL-13) is an immunoregulatory cytokine which plays an important role in carcinogenesis through affecting tumor immunosurveillance. IL-13 in the bladder cancer patients suggests that this cytokine is involved in progression in bladder cancer patients.

Midkine is a member of a family of heparin-binding growth factors, which was reported to have an important role in angiogenesis and is associated with bladder cancer progression.

Bladder Tumor Antigen (BTA) known as human complement factor H-related protein to aids in management of patients with bladder cancer.

The Evidence Investigator

Meet the Evidence Investigator

Developed for use on the Evidence Investigator, a semi-automated benchtop immunoassay analyser.

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    Cost effective and efficient multiplex testing solution
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    Comprehensive immunoassay & molecular test menu available
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    Limited sample volume requirement
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    Medium to high throughput
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    Suitable for clinical and research testing
Evidence Investigator

Want to know more?

Contact us or visit our Investigator Webpage

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