Key Benefits of the Ceruloplasmin reagent
Wide measuring range
The healthy range for ceruloplasmin is 20 – 60 mg/dl. The Randox ceruloplasmin reagent can comfortably detect levels outside of the healthy range measuring between 6.29 – 73.8 mg/dl.
Exceptional correlation with standard methods
The Randox methodology was compared against other commercially available methods and the Randox ceruloplasmin assay showed a correlation coefficient of r=0.95.
Liquid ready-to-use reagents
The Randox assay comes in a liquid format which is more convenient as the reagent does not need to be reconstituted which aids in reducing the risk of errors occurring.
Other features of the Ceruloplasmin reagent
- Immunoturbidimetric method
- Stable until expiry date when stored at +2 to +8⁰C
- Measuring range 6.29 – 73.8 mg/dl
- Correlation coefficient of r=0.95
- A range of fully automated applications available
What is the Ceruloplasmin assay used for?
What is ceruloplasmin?
Ceruloplasmin is a glycoprotein that is produced in the liver. Specifically, it is a multicopper ferroxidase responsible for the homeostasis of iron and copper and it integrates with these metabolic pathways. When genes are mutated, the biosynthesis of ceruloplasmin becomes impaired which, in turn, disturbs the metabolism with the decomposition of iron in different organs. Elevated concentration levels are seen in individuals with: bacterial infections, Leukaemia, Hodgkin’s Disease, Systemic Lupus Erythematosus (SLE), rheumatoid arthritis, inflammation, severe infection, and Alzheimer’s Disease.
What is the ceruloplasmin assay used for?
The Randox ceruloplasmin assay is used to monitor copper metabolism within the body. Dysfunction of the copper-transporting ATPase (ATP7B) leads to the development of Wilson disease which is a rare autosomal recessive inherited disorder of copper metabolism. It is characterised by decreased levels of ceruloplasmin resulting in the excessive decomposition of copper in the liver, brain, and other tissues which results in liver damage and neurological deterioration. If left untreated, Wilson disease can be fatal. Early detection and treatment is therefore crucial in order to prevent permanent damage and halt disease progression. For more information on the mutational analysis of ATP7B and the genotype-phentotype correlation in Wilson disease, please click here [external link].