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Amphiregulin (AREG) is a biologically active growth factor that binds to the epidermal growth factor receptor (EGFR), playing a vital role in cell growth, tissue regeneration, and immune system regulation.

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To find out more about the Novel Biomarkers – Amphiregulin (AREG), enquire now.

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Amphiregulin (AREG)

Produced by activated immune cells, AREG exists first as a membrane-bound precursor (pro-AREG) and is later released in its soluble form to activate EGFR pathways. Because of its central role in EGFR signalling, Amphiregulin is being explored as a novel biomarker for various cancers, inflammatory conditions, and fibrotic diseases.

AREG is involved in a wide range of biological processes, including:

  • Tissue Repair and Regeneration: Promotes healing and cell proliferation after injury.
  • Immune Modulation: Supports type 2 immune responses that help resolve inflammation.
  • Pubertal Development: Linked to breast development and onset of puberty in females.
  • Ovarian Function: Stimulates ovulation through luteinising hormone activity.

Although AREG is found in low concentrations in healthy individuals, its levels significantly rise in response to cellular stress, tissue injury, or malignancy.

Other Applications

Ongoing research is evaluating AREG as a diagnostic and prognostic blood biomarker for the following conditions:

  • Cancer diagnosis and staging (breast, ovarian, liver, lung, and colorectal)
  • Fibrotic liver diseases
  • Tissue injury and repair monitoring
  • Hormonal and reproductive health

Biochip Array Technology

Randox biochip technology enables precise measurement of sPD-1, providing valuable insights into immune regulation and disease progression.

The Evidence MultiSTAT

Evidence MultiSTAT

The Evidence MultiSTAT is an easy to use, small footprint analyser facilitating on-site simultaneous detection of multiple biomarkers.

Using chemiluminescence as a measurement principle, the Evidence MultiSTAT consistently delivers accurate results.

With minimal sample preparation required, this versatile benchtop analyser can achieve accurate, quantitative results in minutes.

MultiSTAT Cartridge

The Evidence MultiSTAT cartridge contains the reagents required for the chemiluminescent reaction to take place incorporated into its wells.

The process from sample entry to results can be completed in 2 simple steps, with minimal risk of human error.

No other components are required.

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