Early detection of Kidney Damage with CKD Arrays I and II

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Chronic Kidney Disease

Why are kidneys important to our health?

The two fist-sized organs which are located under the ribs and on each side of the spine play several important functions in the body. It is extremely vital to keep them healthy. Using their tiny nephrons the kidneys filter extra water and toxins from the blood.1 They filter about 120 to 152 quarts (113 to 144 liters) of blood to create 1 to 2 quarts (0.94 to 1.8 l) of urine every day, according to the National Institute of Health (NIH)2.

Kidneys also keep electrolytes such as potassium and sodium balanced to make hormones that will help with pressure function and the creation of red blood cells; and promote bone health by making a form of vitamin D. 1 If your kidneys fail, it leads to harmful wastes building up therefore, blood pressure will rise, your body will retain excess fluid and shortness of breath.

What is Chronic Kidney Disease?

Chronic Kidney Disease (CKD) is a long-term condition that damages your kidneys and decreases their ability to keep you healthy. The kidneys’ main role is to filter waste products from the blood before converting them into urine. Chronic Kidney Disease is the reduced ability of the kidney to carry out these functions in the long term.

Anyone can be affected with Chronic Kidney Disease but it is mainly associated with age. NHS states that the older you get the more likely you are to have some degree of the disease. One in five men and one in four women between the ages of 65 and 74 have some degree of Chronic Kidney Disease. 2 Overall, 3 million people in the UK have Chronic Kidney Disease. 3

Kidney disease is usually caused by other conditions that put a strain on the kidneys such as high blood pressure, diabetes, high cholesterol or kidney infections.

If the kidney isn’t looked after during the condition, it can get gradually worsen over time and in an uncommon situation the kidneys may stop working. If the kidneys are looked after people who have Chronic Kidney Disease can live a long normal life.

Symptoms of Chronic Kidney Disease:

At the early stages of Chronic Kidney Disease there are no visual symptoms because the body is able to cope with a significant reduction in kidney function. The only way to diagnose Chronic Kidney Disease is to take a blood or urine test. 4

However, at later stages of Chronic Kidney Disease the symptoms start to develop. The symptoms include the following:

  • Weight loss and poor appetite
  • Swollen ankles, feet or hands
  • Shortness of breath
  • Tiredness
  • Blood in urine
  • Increased need to pee
  • Difficulty to sleep
  • Headaches
  • Feeling sick

 How to improve kidney health?

Drinking plenty of fluids and eating all the vitamins and minerals your body needs will help your kidneys to function properly. Decreasing your smoking and drinking is important as they can raise your blood pressure, which is a common cause of Chronic Kidney Disease.

What can we offer?

Randox Clinical Laboratory Services offers two arrays known as CKD Array I and II. They utilise our award-winning Biochip Array Technology (BAT) which simultaneously and quantitatively detects multiple early biomarkers associated with kidney damage to allow diagnosis for earlier treatment, as well as the prevention of further damage. If you require your samples to be tested as part of a clinical trial or a research project we are on hand to help accelerate your project.

The CKD I Array comprises 7 biomarkers; EGF, FABP1, sTNFR1, IL-8, D-Dimer, MIP-1 alpha and sTNFR2 and the CKD II Array comprises 4 biomarkers; C3a des Arg, CRP, NGAL and Cystatin.

If you would like more information on Randox Clinical Laboratory Services, please contact us by emailing us at info@rcls.com

  1. https://www.stjhs.org/healthcalling/2016/may/why-your-kidneys-are-important/
  2. https://www.nhsinform.scot/illnesses-and-conditions/kidneys-bladder-and-prostate/chronic-kidney-disease
  3. https://www.kidneycareuk.org/news-and-campaigns/facts-and-stats/
  4. https://www.nhs.uk/conditions/kidney-disease/symptoms/

 

 

 

 

 

 

 

 

 



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