Apolipoprotein C-III (Apo C-III) Assay
Reagent | Apolipoprotein C-III (Apo C-III)
An Independent Risk Factor for CVD
Benefits of the Randox Apo C-lll Assay
Immunoturbidimetric method
The immunoturbidimetric method limits interference from Bilirubin, Haemoglobin, Intralipid® and Triglycerides, producing more accurate results.
Exceptional correlation
A correlation coefficient of r=1.00 was displayed when the Randox apo C-III assay was compared to commercially available methods.
Excellent measuring range
The Randox apo C-III assay has a measuring range of 2.06 – 21.7mg/dl for the comfortable detection of clinically important results.
Liquid ready-to-use
The Randox apo C-III assay is available in a liquid ready-to-use format for convenience and ease-of-use.
Dedicated calibrator and controls available
Randox offer dedicated apolipoprotein calibrator and controls for a complete testing package.
Applications available
Applications available detailing instrument-specific settings for the convenient use of the Randox apo C-III assay on a variety of clinical chemistry analysers.
Ordering Information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| LP3865 | R1 2 x 11ml (L) R2 2 x 5ml | Enquire | Kit Insert Request | MSDS | Buy Online |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
Clinical Significance
Not only is apo C-III a key regulator in the metabolism of triglycerides, but it is also an independent risk factor for CVD. Not only does apo C-III contribute to CVD through the regulation of triglycerides but also through its direct atherogenic effects, promoting atherosclerosis (fig 1) 1.
Fig. 1. Pleiotropic effects of apo C-III 1
Physiological Significance
Apo C-III is composed of 79 amino acids and has a molecular weight of 8.8kDa. Apo C-III promotes hypertriglyceridemia via several mechanisms. Firstly, like apo C-II, apo C-III also inhibits the activity of LPL, distributing lipid lipolysis. Apo C-III hinders the binding of apolipoprotein B and apolipoprotein E to the hepatic receptors resulting in the delayed catabolism of triglyceride – rich lipoproteins (TRLs). Finally, apo C-III prefers the production and secretion of very low-density lipoproteins (VLDL) in the liver 1.
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Apolipoprotein Control
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Superoxide Dismutase (Ransod)
Superoxide Dismutase (Ransod)
Powered by BiozBenefits of the Randox Ransod Assay
Excellent correlation
A correlation coefficient of r=0.965 was displayed when the Randox Ransod assay was compared against commercially available methods.
Excellent precision
The Randox Ransod assay displayed a within run precision of <4.65% CV.
Excellent measuring range
The Randox Ransod assay has a measuring range of 0.00 – 5.50 U/ml for the comfortable detection of clinically important results.
Standard included in kit
The standard is supplied with the Ransod kit, simplifying the ordering process.
Dedicated Ransod control available
A dedicated Ransod control is available offering a complete testing package.
Applications available
Applications available detailing instrument-specific settings for the convenient use of the Randox Ransod assay on a variety of clinical chemistry analysers.
Ordering information
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
| Cat No | Size | ||||
|---|---|---|---|---|---|
| SD125 | 5 x 20ml (S) | Enquire | Kit Insert Request | MSDS | Buy Online |
| (S) Indicates standard included in kit | |||||
Superoxide dismutase (SOD) are a group of metalloenzymes, the first line of defence against reactive oxygen species (ROS)-medicated injury. SOD is responsible for catalysing the dismutation of the superoxide anion free radical (O2–) into molecular oxygen and hydrogen peroxide (H2O2). The aim of this process is to reduce the levels of O2– as it damages cells at excessive concentrations 1.
SOD is the most important antioxidant defence against oxidative stress. SOD is a severe anti-inflammatory agent and can prevent precancerous cell changes. Reduced SOD levels have been observed in older generations as SOD levels drop as the body ages and so are more prone to oxidative related diseases. Reduced SOD activity has been identified as having a strong correlation with Alzheimer’s Disease. The overexpression of SOD-2 reduces hippocampal superoxide, preventing memory defects 1. Moreover, SOD has been identified as a potential diagnostic and prognostic marker in patients with gastric cancer 2. SOD has also been linked to other health conditions, including: rheumatoid arthritis, RBC-related disorders, Crohn’s Disease, cystic fibrosis, malignant breast cancer and neuronal apoptosis 1, 3.
Fig. 1. Pathological effects associated with SOD gene mutation or SOD deficiency 4
Publications
Related Products
Ransod Control
Antioxidants Panel
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Aldolase Assay
Reagent | Aldolase
A Myositis Biomarker
Benefits of the Randox Aldolase Assay
Exceptional Correlation
A correlation coefficient of r=0.9917 was displayed when the Randox methodology was compared against commercially available methods.
Measuring Range
The Randox Aldolase assay has a measuring range of 1.73 – 106U/l for the comfortable detection of clinically important results.
Lyophilised Reagents
Lyophilised reagents offer enhanced stability, reducing wastage.
Excellent Precision
The Randox assay displayed a within run precision < 4.47% CV.
Dedicated Calibrator and Controls Available
Randox offer a dedicated Aldolase calibrator and controls for a complete testing package.
Applications Available
Applications available detailing instrument-specific settings for the convenient use of the Randox Aldolase assay on a variety of clinical chemistry analysers.
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| AD189 | 5 x 20ml | Enquire | Kit Insert Request | MSDS | Buy Online |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
Clinical Significance
Elevated levels of aldolase are detected in myotonic muscular disease, including: polymyositis and progressive muscular dystrophy. Elevated levels of this enzyme have been observed in acute coronary syndromes 1. This enzyme has been identified as a myositis biomarker, a muscle-wasting disease resulting in reduced muscle strength and fatigue 2. Testing this enzyme can be utilised as a marker in the differential diagnosis of muscle weakness as aldolase levels remain consistent where weakness is caused by neurological problems such as multiple sclerosis (MS) 3.
Physiological Significance
Aldolase is a glycolytic enzyme responsible for catalysing the conversion of fructose 1-6-diphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate via the glycolysis metabolic pathway. This enzyme is present in all bodily cells, more commonly in the nucleus and cytoplasm. It has been identified as having three isoforms: A, B and C. Isoform A is found bound to the actin-containing filament of the cytoskeleton. By binding (reversible) to these filaments, aldolase aids in regulating cell contractions. The highest concentrations of this enzyme are present in the brain, liver and muscles 1.
Related Products
Aldolase Calibrator
Aldolase Control
A-Z Randox Reagents
References
[2] The Myositis Association. About Myositis. https://www.myositis.org/about-myositis/ (accessed 27 February 2020)
[3] The Myositis Association. Blood Tests. https://www.myositis.org/about-myositis/diagnosis/blood-tests/ (accessed 27 February 2020).
Anti-Streptolysin O (ASO) Reagent
Reagent | Anti-Streptolysin O (ASO)
Key benefits of the Anti-Streptolysin O reagent
Excellent correlation to standard methods
The Randox Anti-Streptolysin O assay showed an excellent correlation coefficient of 0.97 compared against other commercially available methods.
Excellent stability
Stable until expiry date when stored at +2 to +8°C
Specificity
The antiserum of Randox Anti-Streptolysin O is monospecific for human ASO and has not been shown to cross react with other serum proteins.
Liquid ready-to-use
Available in a liquid ready-to-use format for convenience and ease-of-use.
Applications available
Applications available detailing instrument-specific settings for the convenient use of the Randox albumin assay on a variety of clinical chemistry analysers.
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| LO3998 | R1 2 x 9ml (L) R2 2 x 14ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| LO8015 | R1 2 x 8.7ml R2 2 x 12ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| LO8305 | R1 1 x 7.7ml (L) R2 1 x 11.2ml | Enquire | Kit Insert Request | MSDS | Buy Online |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is the Anti-Streptolysin O (ASO) assay used for?
What is Anti-Streptolysin O (ASO)?
Streptolysin O (SLO) is a toxic and lethal, exocellular immunogenic protein produced and released in response to Group A Streptococcal pyogenes. For more information on streptococcal infections, please click here [external link]. The release of SLO stimulates the production of Anti-Streptolysin O (ASO) antibodies to neutralise the SLO’s haemolytic effects. The O in the name stands for oxygen-labile.
What is the Anti-Streptolysin O (ASO) assay used for?
The Anti-Streptolysin (ASO) test is used to determine recent streptococcal infection and post streptococcal complications which includes rheumatic fever and glomerulonephritis. The presence and level of ASO antibodies in human serum directly reflects the extent and degree of infection. Elevated levels of ASO may also be present in other conditions including scarlet fever, acute rheumatoid arthritis, tonsillitis and various other streptococcal infections as well as in health carriers.
The Randox Anti-Streptolysin (ASO) assay is used to measure the presence of anti-streptolysin antibodies in the blood to determine if a strep infection is present.
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Specific Protein Panel
For more information or to visit more reagents within the specific proteins panel, please click here.
Rapid Tests / Serology Panel
For more information or to visit more reagents within the rapid tests / serology panel, please click here.
Antioxidant Reagents
Why Choose Randox Antioxidants Reagents?
The Randox range of antioxidant reagents are designed for use within a variety of sectors including clinical, research, veterinary, pharma, food and beverages, cosmetics and sports. Furthermore, our range of antioxidant reagents include routine antioxidant reagents, as well as more specialised tests that are unique to Randox.
Randox Antioxidant Reagents Benefits
The role of antioxidant reagents
Antioxidants are important for the body’s immune system to protect the body against free radical attacks. Randox provides a range of antioxidant reagents to assess all three levels of the body’s defence system (preventative antioxidants, scavenging antioxidants and repair enzymes).
Preventative antioxidants – inhibit the formation of free radicals including metal binding proteins like; Ceruloplasmin, Metallothionine, Albumin, Transferrin, Ferritin and Myoglobin.
Repair enzymes – repair damaged biomolecules such as DNA repair enzymes.
Scavenging antioxidants – remove any reactive species once formed such as Superoxide Dismutase, Glutathione Peroxidase, Catalase and small molecules including Ascorbate, Tocopherol, Bilirubin, Uric Acid, Carotenoids and Flavonoids.
Antioxidant benefits against disease
Free radicals have been found to play a role in the development of many diseases including cancer (free radicals are thought to promote cell transformation into a cancer cell), arthritis and inflammatory diseases (increased oxidative stress in rheumatoid arthritis patients suggests antioxidants could have an important role), cardiovascular disease (antioxidants have been found to improve cardiac health), and Alzheimer’s disease (antioxidants have a role in removing deleterious free radicals from the brain).
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Get in touch with Randox via email at reagents@randox.com
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Amylase Reagent
Reagent | Amylase
Key Benefits of the Randox Amylase reagent
Excellent stability – Stable to expiry when stored at +2 to +8°C
Methodology – Ethylidene PNPG7 method
Liquid ready-to-use reagents – The Randox reagent comes in a liquid ready-to-use format which is more convenient as the reagent does not need to be reconstituted which aids in reducing the risk of errors occurring
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| AY3805 | R1 4 x 16ml (L) R2 4 x 5ml (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
| AY7931 | R1 6 x 50ml (L) R2 4 x 18ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| AY8004 | R1 7 x 18ml (L) R2 7 x 7.3ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| AY8335 | R1 4 x 20ml (L) R2 4 x 7ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Amylase used for?
It is a digestive enzyme / special protein produced by the pancreas and salivary glands. Salivary amylase is responsible for breaking down starch in the mouth and converting it into maltose. Pancreatic amylase passes through a duct from the pancreas to the small intestine where the digestive process is completed through converting starch into glucose. The glucose is then absorbed into the blood and carried throughout the body.
Damage or inflammation to the pancreas can result in under / over production of amylase which can be a sign of pancreatic disorder which includes pancreatic pseudocyst, pancreatic abscess, pancreatic cancer, gallbladder disease, mumps or ectopic pregnancy. For more information on pancreatic cancer, please click here. The Randox assay is used for the quantitative in vitro determination of amylase activity in serum, urine and plasma.
IgG
Reagent | IgG
Key Benefits of IgG
Excellent precision
The IgG assay showed a precision of less than 4% CV
Exceptional correlation
The assay showed a correlation of r=0.99 against another commercially available method
Completely automated protocols
Available for a range of analysers
Other features
- Immunoturbidimetric method
- Liquid ready-to-use reagents
- Open vial stability of 28 days at 10⁰C
- Measuring range 1.61 – 56 g/l
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| IG3833 | R1 3 x 20ml (L) R2 3 x 14ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| IG8044 | R1 4 x 10.5ml (L) R2 4 x 4ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is IgG used for?
Measurement of immunoglobulin G is the basis of the serological diagnosis of several infectious diseases. Uses of IgG measurement include diagnosis of infectious and inflammatory diseases, diagnosis of malignancies, to detect the presence of soluble antigens and monitoring therapy in myeloma.
The Randox IgG assay is an immunoturbidimetric end-point method for manual use and on automated analysers. The increase in turbidity in a sample containing human IgG is measured at 340 nm.
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Specific Proteins Panel
For more information or to view more reagents within the specific proteins panel, please click here
Ammonia Reagent
Ammonia
Key Benefits of the Randox Ammonia reagent
Lyophilised Reagents
Lyophilised reagents offer enhanced stability, reducing wastage.
Suitable for use on a range of analysers
The Randox Ammonia reagent is suitable to use on a number of third party analysers Including Abbott, Olympus, Cobas and Hitachi.
Stability
Stable for 3 weeks at+2 to +8°C or 5 days at +15 to +25°C
Other features
- Enzymatic UV method
- Lyophilised reagents
- Stable for 3 weeks at +2 to +8°C or 5 days at +15 to +25°C
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| AM1015 | R1a. 10 x 5ml R1b. 1 x 70ml R2. 2 x 2ml (C) | Enquire | Kit Insert Request | MSDS | Buy Online |
| AM3979 | R1 4 x 20ml R2 2 x 10ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (C) Indicates calibrator included in kit (S) Indicates standard included in kit |
|||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Ammonia assay used for?
The Randox assay is used for the quantitative in vitro determination of ammonia in plasma.
Ammonia is a nitrogen waste compound and forms when the protein is broken down by bacteria in the intestines. The liver then converts it into urea which is normally excreted from the body in urine. Excessive concentration levels is poisonous to cells and occurs as a result of liver or kidney malfunctions. Several diseases, both inherited and acquired can result in significantly elevated concentration levels resulting in hyperammonemia.
Reye’s syndrome is an acquired hyperammonemia disease and is characterised by high concentration levels of ammonia and decreased concentration levels of glucose. As such, an ammonia test is not usually carried out independently and is usually tested alongside glucose, electrolytes, kidney and liver function tests in adolescents and children showing symptoms. For more information on Reye’s syndrome, please click here . Excessive concentration levels is also associated with both liver disease and renal failure which is toxic to the central nervous system.
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Standard included in AM1015 and AM1054
Alanine Aminotransferase (ALT) Reagent
Alanine Aminotransferase (ALT) Reagent
Key Benefits of the Alanine Aminotransferase (ALT) reagent
Flexibility
Liquid and lyophilised reagents available to offer greater customer choice
Suitable for use on a range of analysers
Alanine Aminotransferase (ALT) Reagent is suitable to use on a number of third party analysers Including Abbott, Olympus, Cobas and Hitachi.
Stability
ALT is stable for up to 14 days when stored at +2 to +8°C
More features of the Alanine Aminotransferase (ALT) reagent
- IFCC method
- Available as liquid and lyophilised reagents
- Stable to for up to 14 days when stored at +2 to +8°C
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| AL1205 | R1a. 1 x 105ml R1b. 10 x 10ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| AL7930 | R1 7 x 100ml (L) R2 3 x 60ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| AL3801 | R1 6 x 51ml (L) R2 6 x 14ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| AL8006 | R1 6 x 56ml (L) R2 6 x 20ml (Mod. IFCC) | Enquire | Kit Insert Request | MSDS | Buy Online |
| AL8304 | R1 4 x 20ml (L) R2 4 x 7ml (Mod ?IFCC) | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
Randox ALT-Colorimetric ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| AL146 | R1. 1 x 100ml R2. 1 x 100ml R3. 1 x 100ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (S) Indicates standard included in kit | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is ALT assay used for?
Alanine Aminotransferase is one of the enzymes within the aminotransferases group and are among the most sensitive liver enzymes. The highest concentrations of the ALT enzyme can be in the liver, with decreasing concentrations found in the kidneys, heart, skeletal muscle, pancreas, spleen and lung tissue respectively.
ALT measurements are used in the diagnosis of hepatic damage and diseases including viral hepatitis and cirrhosis.
The normal concentration levels of ALT in the blood are low, however, when damaged, the liver releases more ALT into the blood causing the concentration levels to rise. When diagnosing for hepatic damage, the root cause of the damage can be established, such as disease, drug, or injury
The ALT test not only allows for the diagnosis of liver disease but also allows for the diagnosis of the root cause of the disease
It is often tested in combination with the aspartate aminotransferase (AST) test as part of the hepatic panel with alanine aminotransferase levels being higher in most types of liver disease. For more information on the validity and clinical utility of AST and ALT when assessing disease severity, please click here
