IgA

Home - assay - Page 5

IgA

Reagent | IgA

Key Benefits

Excellent precision

The IgA assay showed a precision of less than 3% CV

Exceptional correlation

The assay showed a correlation of r=0.98 against another commercially available method

Interference

There is no cross reaction with IgG and IgM under the conditions of the assay. Extremely lipaemic or haemolytic samples and high levels of ionic detergents may interfere in the assay

Other features

  • Immunoturbidimetric method
  • Liquid ready-to-use reagents
  • Stable to expiry when stored at +2⁰C to +8⁰C
Cat NoSize
IA3832R1 3 x 20ml (L)
R2 3 x 14ml
EnquireKit Insert RequestMSDSBuy Online
IA8046R1 5 x 8.7ml (L)
R2 5 x 3.9ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is IgA assay used for?

Measurement of IgA is used to diagnose diseases of the respiratory tract e.g. tuberculosis, Crohn’s disease and early cirrhosis of the liver. It is also useful in monitoring therapy of IgA myeloma and evaluating IgA immunity. IgA in colostrum and milk is important in neonatal defence against infection.

The Randox IgA assay is an immunoturbidimetric end-point method for manual use and on automated analysers. The increase in turbidity in a sample containing human IgA is measured at 340 nm. By constructing a standard curve from the absorbances of standards, the IgA concentration of a sample can be determined.

Specific Proteins Panel

For more information or to view more reagents within the specific proteins panel, please click here


Haptoglobin

Reagent | Haptoglobin

Key Benefits

Excellent traceability

Standardised to Certified Reference Material (CRM Da470k/IFCC)

Exceptional correlation

A correlation coefficient of r=0.97 was obtained against another commercially available kit

Excellent stability

Onboard reagent stability of 28 days. Calibration is only required every seven days

Other features and benefits

  • Immunoturbidimetric method
  • Liquid reagents
  • Stable to expiry when stored at +2 to +8°C
  • Fully automated applications available for a wide range of clinical chemistry analysers

Ordering information

Cat NoSize
HP3886R1 1 x 12ml (L)
R2a 1 x 3.2ml
R2b 1 x 0.625ml
EnquireKit Insert RequestMSDSBuy Online
HP8151R1 1 x 12ml (L)
R2 2 x 4.2ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Haptoglobin assay used for?

Haptoglobin measurements are used in the diagnosis of haemolytic anaemia and to distinguish it from other types of anaemia. In haemolytic anaemia, haptoglobin levels in the blood decrease significantly. Low levels however may also indicate red blood cell destruction due to sickle cell anaemia or thalassemia. In certain cases of liver disease haptoglobin levels may also be low, as the liver cannot manufacture normal levels of the protein.

As an acute phase reactant haptoglobin levels in the blood are significantly increased in response to infection, inflammation, burns, surgery and trauma. However, haptoglobin is not generally used to diagnose or monitor these conditions.

Publications


    Specific Proteins Panel

    For more information or to view more reagents within the specific proteins panel, please click here


    Complement C4 Reagent

    Reagent | Complement C4

    Key Benefits of the Randox Complement C4 reagent

    Exceptional correlation with standard methods

    The Randox methodology was compared against other commercially available methods and the Randox Complement C4 assay showed a correlation coefficient of r=0.98

    Wide measuring range

    The healthy range for Complement C4 is 7 -49 mg/dl. The Randox Complement C4 assay can comfortably detect levels outside of the healthy range measuring between 2.90 – 152 mg/dl

    Excellent stability

    Stable until expiry date when stored at +2 to +8°C

    Other features of the Randox Complement C4 reagent

    • Immunoturbidimetric method
    • Liquid ready-to-use reagents
    • Stable until expiry date when stored at +2 to +8°C
    • Measuring range 2.90 – 152 mg/dl

    Ordering information

    Cat NoSize
    CM3846R1 3 x 20ml (L)
    R2 3 x 6ml
    EnquireKit Insert RequestMSDSBuy Online
    CM8024R1 2 x 11.2ml (L)
    R2 2 x 4.2ml
    EnquireKit Insert RequestMSDSBuy Online
    (L) Indicates liquid option

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is the Complement C4 assay used for?

    What is Complement C4?

    The complement system is one of the major mechanisms of innate immunology consisting of more than 30 plasma and membrane-associated serum proteins which evokes cytolytic immune responses to pathogens, including viruses, bacteria, chemical tissue damage and anything that is classified as foreign to the body. The complement system can be activated through three major pathways: classical, lectin or alternative. Once activated, reactions occur for antibody opsonisation (the process by which a phagocyte marks a pathogen for ingestion and elimination) to fight against the foreign bodies.  Activation can also occur when the body produces antibodies for its own tissues that it views as being foreign, which is known as an autoimmune disorder.

    During the activation process, Complement C4 splits down into C4b and C4a (peptide). C4b acts as an opsonin and remains bound to the complex at the surface of the pathogen which activates the next step of the process. The small peptide, C4a diffuses away and acts as a chemotactic factor and an inflammatory paracrine.

    The Randox Complement C4 assay is used for the quantitative in vitro determination of complement C4 concentration in serum.  The Randox Complement C4 assay allows for the diagnosis and monitoring of autoimmune disorders associated with abnormal levels of complement C4 including lupus and rheumatoid arthritis (RA).  Higher than normal results may be indicative of cancer or ulcerative whereas lower than normal results may be indicative of lupus, hepatitis, or cirrhosis.

    Cell-bound levels of processed complement activation products, especially E-C4d (erythrocyte-bound C4) is a biomarker in the diagnosis and monitoring of systematic lupus erythematous (SLE). For more information on SLE, please click here.

    Specific Proteins Panel

    For more information or to view more reagents within the specific proteins panel, please click here


    Complement C3 Reagent

    Reagent | Complement C3

    Key Benefits of the Randox Complement C3 reagent

    Exceptional correlation with standard methods

    The Randox methodology was compared against other commercially available methods and the Randox Complement C3 assay showed a correlation coefficient of r=0.98

    Wide measuring range

    The healthy range for Complement C3 is 58 – 170 mg/dl.  The Randox Complement C3 assay can comfortably detect levels outside of the healthy range measuring between 13 – 502 mg/dl.

    Excellent stability

    Stable until expiry date when stored at +2 to +8°C

    Other features of the Randox Complement C3 reagent

    • Immunoturbidimetric method
    • Liquid ready-to-use reagents
    • Stable until expiry date when stored at +2 to +8°C
    • Measuring range 13 – 502 mg/dl

    Ordering information

    Cat NoSize
    CM3845R1 3 x 20ml (L)
    R2 3 x 6ml
    EnquireKit Insert RequestMSDSBuy Online
    CM8023R1 2 x 11.2ml (L)
    R2 2 x 4.2ml
    EnquireKit Insert RequestMSDSBuy Online
    (L) Indicates liquid option

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is the Complement C3 assay used for?

    What is Complement C3?

    The complement system is one of the major mechanisms of innate immunology consisting of more than 30 plasma and membrane-associated serum proteins which evokes cytolytic immune responses to pathogens, including viruses, bacteria, chemical tissue damage and anything that is classified as foreign to the body. The complement system can be activated through three major pathways: classical, lectin or alternative. Once activated, reactions occur for antibody opsonisation (the process by which a phagocyte marks a pathogen for ingestion and elimination) to fight against the foreign bodies.  Activation can also occur when the body produces antibodies for its own tissues that it views as being foreign, which is known as an autoimmune disorder. For more information on autoimmune disorders, please click here

    During the activation process, Complement C3 splits down into C3b and C3a (peptide). C3b acts as an opsonin and remains bound to the complex at the surface of the pathogen which activates the next step of the process. The small peptide, C3a diffuses away and acts as a chemotactic factor and an inflammatory paracrine.

    The Randox Complement C3 assay is used for the quantitative in vitro determination of complement C3 concentration in serum.  The Randox Complement C3 assay allows for the diagnosis and monitoring of autoimmune disorders associated with abnormal levels of complement C3 including lupus and rheumatoid arthritis (RA).  Higher than normal results may be indicative of cancer or ulcerative whereas lower than normal results may be indicative of lupus, hepatitis, or cirrhosis.

    Publications


      Specific Proteins Panel

      For more information or to visit more reagents within the specific proteins panel, please click here


      Rheumatoid Factor

      Reagent | Rheumatoid Factor

      Rheumatoid Factor Key Benefits

      Exceptional correlation

      The Rheumatoid Factor assay showed a correlation of r=0.99 against another commercially available method

      Applications available

      For a wide variety of clinical chemistry analysers including the RX series

      Excellent stability

      Stable to expiry when stored at 2-8⁰C

      Superior Method

      Latex Enhanced Immunoturbidimetric method

      Ultimate convenience

      Liquid ready-to-use reagents

       Ordering information

      Cat NoSize
      RF3836R1 2 x 20ml (L)
      R2 2 x 8ml
      EnquireKit Insert RequestMSDSBuy Online
      RF8063R1 2 x 8.7ml (L)
      R2 2 x 4.7ml
      EnquireKit Insert RequestMSDSBuy Online
      RF8345R1 1 x 11.7ml (L)
      R2 1 x 5.7ml
      EnquireKit Insert RequestMSDSBuy Online
      (L) Indicates liquid option

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      What is Rheumatoid Factor assay used for?

      Research has shown that both environmental and genetic factors can affect the production of RF with various biological properties. Although they may be found in all immunoglobulin classes, the RF most frequently detected is the IgM type; present in about 75% of adult patients with RA and about 10% of children with juvenile RA. RF have also been observed in the serum of patients with lupus erythematosus, hepatitis, liver cirrhosis, syphilis and various other conditions; but the RF titre is much lower than in RA.

      Specific Proteins Panel

      For more information or to view more reagents within the specific proteins panel, please click here

      Rapid Tests / Serology Panel

      For more information or to view more reagents within the rapid tests / serology panel, please click here


      HbA1c

      Reagent | HbA1c

      HbA1c (Indirect)

      Key Benefits

      Latex Enhanced Immunoturbidimetric method

      The Randox assay utilises a latex enhanced immunoturbidimetric method for superior performance

      Exceptional correlation to standard methods

      A correlation coefficient of 0.98 was obtained with another commercially available method

      Excellent precision

      The HbA1c assay showed a precision of less than 5% CV

      Other Features

      • Latex enhanced immunoturbidimetric method
      • Liquid ready-to-use reagents
      • Stable to expiry when stored at 2-8°C
      • Haemoglobin denaturant supplied with the kit
      Cat NoSize
      HA3830R1 3 x 14ml (L)
      R2 3 x 14ml
      R3 3 x 50ml
      EnquireKit Insert RequestMSDSBuy Online
      HA8321R1 4 x 7.8ml (L)
      R2 4 x 7.8ml
      R3 4 x 40ml
      EnquireKit Insert RequestMSDSBuy Online
      (L) Indicates liquid option

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      HbA1c (Direct)

      • Latex enhanced immunoagglutination method
      • Liquid ready-to-use reagents
      • Stable to expiry when stored at +2 to +8°C
      • For use with RX series of clinical chemistry analysers
      Cat CodeSize
      HA8123R1 2 x 16.2ml (L)
      R2 2 x 8.2ml
      EnquireKit Insert RequestMSDSBuy Online
      HA8379R1 4 x 12.7ml (L)
      R2 4 x 6ml
      EnquireKit Insert RequestMSDSBuy Online
      HA4068R1 4 x 20ml (L)
      R2 4 x 8.6ml
      EnquireKit Insert RequestMSDSBuy Online
      (L) Indicates liquid option

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      What is HbA1c assay used for?

      The concentration of HbA1c in the blood of diabetic patients increases with rising blood glucose levels and is representative of the mean blood glucose level over the preceding six to eight weeks. HbA1c can therefore be described as a long term indicator of diabetic control unlike blood glucose which is only a short term indicator of diabetic control.

      It is recommended that HbA1c levels are monitored every three to four months. In patients who have recently changed their therapy or in those who have gestational diabetes it may be beneficial to measure HbA1c levels more frequently, at two to four week intervals.

      Diabetes Panel

      For more information or to view more reagents within the diabetes panel, please click here

      Specific Proteins Panel

      For more information or to view more reagents within the specific proteins panel, please click here


      Glucose

      Reagent | Glucose

      Key Benefits

      Exceptional correlation

      The Glucose assay showed a correlation of r=0.99 against another commercially available method

      Excellent stability

      Stable to expiry when stored at 2-8⁰C

      Flexibility

      Liquid and lyophilised reagents available for greater consumer choice

      Randox Glucose (GOD-PAP & Hexokinase)

      • GOD-PAP and Hexokinase method
      • Liquid and lypohilised reagents
      • Stable to expiry when stored at 2-8°C

      Randox Glucose GOD-PAP

      Cat NoSize
      GL8038R1a 4 x 50ml (L)
      R1b 4 x 0.5ml
      EnquireKit Insert RequestMSDSBuy Online
      GL36410 x 100ml (S)EnquireKit Insert RequestMSDSBuy Online
      GL26142 x 500ml (S) (L)EnquireKit Insert RequestMSDSBuy Online
      GL38159 x 51ml (L)EnquireKit Insert RequestMSDSBuy Online
      GL83184 x 20ml (L)EnquireKit Insert RequestMSDSBuy Online
      (L) Indicates liquid option
      (S) Indicates standard included in kit

      Randox Glucose Hexokinase

      Cat NoSize
      GL3816R1 4 x 51ml (L)
      R2 3 x 20ml
      EnquireKit Insert RequestMSDSBuy Online
      GL38814 x 50ml (L)EnquireKit Insert RequestMSDSBuy Online
      GL8319R1 4 x 20ml (L)
      R2 4 x 6.5ml
      EnquireKit Insert RequestMSDSBuy Online
      (L) Indicates liquid option

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      What is Glucose assay used for?

      Glucose is the primary source of energy for the body. The body obtains glucose through the digestion of the sugar and starch in carbohydrates. Glucose is vital and interacts with the digestive and endocrine system. Due to this it is imperative to maintain glucose levels within the normal range.

      • Bor, M.V., et al. Serum fructosamine and fructosamine-albumin ratio as screening tests for gestational diabetes mellitus. Arch. Gynecol. Obstet. 1999, 262(3-4): 105-111
      • Ranganath, L., et al. The effect of circulating non-esterified fatty acids on the entero-insular axis. European Journal of Clinical Investigation. 1999, 29(1): 27-32
      • Joshi, S., et al. Fish oil supplementation of rats during pregnancy reduces adult disease in their offspring. J. Nutr., 2003, 133: 3170-3174
      • Sánchez-Rodríguez, M.A., et al. Antioxidant capacity in relationship to serum lipid peroxides levels in healthy elderly of Mexico City. 2004, 38(2): 193-198
      • Panagia, M., et al. PPAR-α activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. Am. J. Physiol. Heart Circ. Physiol. 2005, 288: H2677-H2683
      • Chen, C-W and Cheng, H-H. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J. Nutr. 2006, 136: 1472-1476
      • Gupta, V. et al. Effect of short term cigarette smoking on insulin resistance and lipid profile in asymptomatic adults. Indian J. Physiol. Pharmacol. 2006, 50(3): 285-290
      • Lutoslawska, G., et al. Relationship between fasting insulin resistance index (FIRI) and plasma glycerol and free fatty acid levels in physically active males and females. Biol. Sport 2006, 23: 341-351
      • Miyashita, M., et al. Exercise and postpandrial lipemia: effect of continuous compared with intermittent activity patterns. Am. J. Clin. Nutr. 2006, 83(1): 24-29
      • Mula-Abed, W-A. S. and Aziz, S.B. Serum fructosamine (glycated protein) and related biochemical parameters during normal pregnancy. JBMS Journal of the Bahrain Medical Society 2006, 18(3): 115-122
      • Camarillo-Romero, M.S. et al. Riesgo cardiovascular en trabajadores universiatarios. (Article in Spanish). BioQCliNat. 2007,4(13): 9-15
      • Halley Castillo E., et al. Body Mass Index and the prevalence of metabolic syndrome among children and adolescents in two Mexican populations. J. Adolesc. Health. 2007, 40(6): 521-526
      • James, A.P., et al. Prior exercise does not affect chylomicron particle number following a mixed meal of moderate fat content.Lipids Health Dis. 2007, 6: 8
      • Mineo, D., et al. Effects of lung volume reduction surgery for emphysema on glycolipidic hormones. Chest. 2008, 134(1): 30-37
      • Aziz, N., et al. Antihypertensive, antioxidant, antidyslipidemic and endothelial modulating activities of a polyherbal formulation (POL-10). Vascul. Pharmacol. 2009, 50(1-2): 57-64
      • Bajaj, S., et al. A case-control study on insulin resistance, metabolic co-variates and prediction score in non-alcoholic fatty liver disease. Indian J. Med. Res. 2009, 129: 285-292
      • Chou T-W., et al. A Rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced Type 2 diabetes. J.Clin. Biochem.Nutr. 2009, 45(1): 29-36
      • García-Montalvo, E.A. et al. Fluoride exposure impairs glucose tolerance via decreased insulin expression and oxidative stress.Toxicology 2009, 263: 75-83
      • Hossein-nezhad, A., et al. Association of VDR gene polymorphism with insulin resistance in diabetic patients. Iranian Journal of Diabetes and Lipid Disorders. 2009, 143-150Kanakkaparambil, R., et al. B-vitamin and homocysteine status determines ovarian response to gonadotropin treatment in sheep. Biol. Reprod. 2009, 80(4): 743-752
      • Li, T-L. and Rush, B. The effects of prolonged strenuous exercise on salivary secretion of IgA subclasses in men. Int. J. Sport Exerc. Sci. 2009, 1(3): 69-752
      • Mirzaei, K., et al. Variation in the vistafin gene may alter the required dosage of oral antidiabetic agents in type 2 diabetic patients. Iranian Journal of Diabetes and Lipid Disorders 2009, 87-94
      • Režen, T., et al. Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers. BMC Genomics. 2009, 10: 384
      • Rhodes, P., et al. Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PloS ONE 2009, 4(10): e7393
      • Sébert, S.P., et al. Maternal nutrient restriction between early and midgestation and its impact upon appetite regulation after juvenile obesity. Endocrinology 2009, 150(2): 634-641
      • Usman K, M., et al. Correlation between non-insulin dependent diabetes mellitus and serum sialic acid. Annals 2009, 15(3): 152-154
      • Velasco-Martínez, R.M., et al. Obesity and insulin resistance among adolescents from Chiapas. Nutr. Hosp. 2009, 24(2)
      • Camarillo-Romero, E., et al. (Article in Spanish). Difficulties in the classification of metabolic syndrome. The example of adolescents in Mexico. Salud Publica Mex. 2010, 52(6): 524-527
      • Iffen, T.S. and Usoro C.A.O. The effect of ethanolic extract of Larpotea ovalifolia plants growing in Calabar on antioxidants status of streptozocin induced diabetic rats. Global Journal of Pharmacology 2010, 4(1): 01-05
      • Itam, E.H., et al. Haemapoietic and immunological changes in multiple low-dose streptozotocin (MDSTZ) rat models. European Journal of Scientific Research. 2010, 43(2): 283-289
      • Mahadik, S.R. et al. Role of adipocytokines in insulin resistance: Studies from Urban Western Indian Population. Int. J. Diabetes & Metab. 2010, 18(9): 35-42
      • Akpaso, M.I. et al. Effect of combined leaf extracts of Vernonia amygdalina (Bitter leaf) and Gongronema latifolium (Utazi) on the pancreatic β-cells of the streptozotocin-induced diabetic rats. British Journal of Medicine and Medical Research. 2011, 1(1): 24-34
      • Chu, N.F et al. Prevalence and anthropometric risk of metabolic syndrome in Taiwanese adolescents. ISRN Cardiol. 2011, 2011: 743640
      • Gupta, V., et al. Association of circulating resistin with metabolic risk factors in Indian females having metabolic syndrome.Toxicol. Int. 2011, 18(2): 168-172
      • Singal, S., et al. Is cardiovascular risk more in diabetics because of lower apolipoprotein A1 levels rather than higher Apo B/Apo A1 ratio? Int. J. Biomed. Res. 2011, 2(2): 143-150
      • Al-Rejaie, S.S., et al. Immobilization stress-induced oxidative damage and its amelioration with green and black teas. Afr. J. Pharm. Pharmacol. 2012, 6(8): 538-545
      • Belaïd-Nouira, Y., et al. Study of lipid profile and parieto-temporal lipid peroxidation in AICI3 mediated neurotoxicity. Modulatory effect of fenugreek seeds. Lipids Health Dis. 2012, 11: 16
      • Camarillo-Romero, E., et al. Effects of a physical activity program on markers of endothelial dysfunction, oxidative stress, and metabolic status in adolescents with metabolic syndrome. ISRN Endocrinol. 2012, 2012: 970629
      • El-Abhar, H.S. and Schaalan, M.F. Topiramate-induced modulation of hepatic molecular mechanisms: an aspect for its anti-insulin resistant effect. PLoS ONE. 2012, 7(5): e37757
      • Gupta, V., et al. Association analysis of 31 common polymorphisms with type 2 diabetes and its related traaits in Indian sib pairs. Diabetologia. 2012, 55: 349-357)
      • Hammouda, O. et al. Effect of short-term maximal exercise on biochemical markers of muscle damage, total antioxidant status, and homocysteine levels in football players. AJSM. 2012, 3(4): 239-246
      • Hossein-nezhad, A. et al. Circulating omentin-1 in obesity and metabolic syndrome status compared to control subjects.Endocrinol. Metabol. Syndrome 2012: S1:008
      • Nagalakshmi, C.S. et al. Exploration of the clinico-biochemical parameters to explain the altered renal mechanisms in gestational diabetes mellitus. J. Clin. Diagn. Res. 2012, 6(3): 369-371
      • Odum, E.P. and Wakwe V.C. Plasma concentrations of water-soluble vitamins in metabolic syndrome subjects. Niger. J. Clin. Pract. 2012, 15: 442-447
      • Odum, E.P., et al. Antioxidant status of type 2 diabetic patients in Port Harcourt, Nigeria. Niger J. Clin. Pract. 2012, 15: 55-58
      • Yahaya, N. et al. Type 2 diabetes with good glycemic control have improved insulin response and lower non-esterified fatty acid level after a meal challenge. Journal of Diabetes Mellitus 2012, 2(1): 1-7
      • Ikhlas, K.H., et al. The relation between serum total sialic acid and the presence of metabolic syndrome in type 2 diabetes mellitus. Iraqui J. Comm. Med. 2013, (1): 37-41
      • Kazeem, M.I., et al. Protective effect of free and bound polyphenol extracts from ginger (Zingiber officinale Roscoe) on the hepatic antioxidant and some carbohydrate metabolizing enzymes of streptozotocin-induced diabetic rats. Evid. Based Complement. Alternat. Med. 2013: 935486
      • Wali, U., et al. Antioxidant status and lipid profile of diabetic rats treated with antioxidant rich locally prepared nutriceutical.IJDD. 2013, 1(2): 033-038
      • Yakubu, N., et al. Antioxidant and hepatoprotective properties of tofu (curdle soymilk) against acetaminophen-induced live damage rats. Biotech. Res. Int. 2013, ID 230142

      Diabetes Panel

      For more information or to view more reagents within the diabetes panel, please click here

      Veterinary Panel

      For more information or to view more reagents within the veterinary panel, please click here


      Total Antioxidant Status (TAS) Assay

      Reagent | Total Antioxidant Status (TAS) 

      A Marker of Overall Antioxidant Status

      Benefits of the Randox TAS Assay

      Superior method

      The Randox TAS assay utilises the colorimetric method, offering convenience and efficiency in comparison to ELISA technology and produces results in as little as 3 minutes.

      Excellent measuring range

      The Randox TAS assay is linear up to 2.50mmol/l enabling the comfortable detection of clinically important results.

      Lyophilised reagents

      Lyophilised reagents offer enhanced stability, reducing wastage.

      Standard supplied with the kit

      The standard is supplied with the TAS kit, simplifying the ordering process.

      Dedicated TAS control available

      Dedicated TAS control available offering a complete testing package.

      Applications available

      Applications available detailing instrument-specific settings for the convenient use of the Randox TAS assay on a variety of clinical chemistry analsyers.

      Ordering information

      • Ordering Information
      Cat NoSize
      NX23325 x 10ml (S)EnquireKit Insert RequestMSDSBuy Online
      (S) Indicates standard included in kit

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      • PHYSIOLOGICAL SIGNIFICANCE
      • Clinical Significance

      Free radicals / reactive oxygen species (ROS) are produced during normal cellular metabolism, however, can have harmful effects. Antioxidants are the first line of defence and are produced by the body to neutralise the harmful effects of ROS, preventing cellular damage 1,2, 3. Measuring total antioxidant status (TAS) can provide information on an individual’s overall antioxidant status, which may include antioxidants not yet recognised or not easily measured. The TAS of a sample is a quantitative measurement of the state of balance of the various components (exerting actions in different way) under specified reaction conditions 4.

      Reduced levels of total antioxidant status (TAS) is indicative of oxidative stress and increased susceptibility to oxidative damage 5. Oxidative stress is an imbalance between the ROS and antioxidants in the body, favouring ROS 6. Oxidative stress is associated with several health conditions, including: chronic inflammation, neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, cancer and CVD 7.

      TAS Control

      Antioxidants Panel

      A-Z Reagents


      Glutathione Peroxidase (Ransel)

      Reagent | Glutathione Peroxidase (Ransel)

      A Marker of Oxidative Stress

      Key Benefits

      Superior Performance

      Superior method

      The Randox Ransel assay utilises the enzymatic method enabling the sensitive and accurate detection of glutathione peroxidase.

      Precision

      Excellent precision

      The Randox Ransel assay displayed a within run precision of <4.86% CV.

      Correlation

      Excellent correlation

      A correlation coefficient of r=0.9829 was displayed when the Randox Ransel assay was compared to commercially available methods.

      Calibrator & Controls

      Dedicated calibrator and control available

      Dedicated Ransel calibrator and control available offering a complete testing package.

      Logos-07

      Applications available

      Applications available detailing instrument-specific settings for the convenient use of the Randox Ransel assay on a variety of clinical chemistry analysers.

      Ordering Information

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      Diagnostic Uses

      • PHYSIOLOGICAL SIGNIFICANCE
      • Clinical Significance

      Glutathione peroxidase (GPx) is a reactive oxygen species (ROS), generated by bodily cells via mitochondrial and enzymatic sources. It is vital that GPx levels are reviewed as it can cause oxidative damage to membrane lipids, proteins and DNA. GPx is an intracellular antioxidant enzyme that enzymatically converts hydrogen peroxide to water (detoxification). Hydrogen peroxidase is vital for the maintenance of normal thiol redox-balance, mitochondrial function, and growth factor-mediated signal transduction. By converting hydrogen peroxidase to water, GPx aids in modulating these processes 1. GPx also contributes to cell signalling and oxidative protein folding 2.

      Four of the eight glutathione peroxidases (GPx) are selenoproteins (containing the amino acid form of selenium, Sec) in humans, however, GPx6 is cysteine-containing in rodents, but a selenoprotein in humans, whereas the remaining GPx’s are cysteine containing. Glutathione peroxidase 4 (GPx4) is emerging as one of the most important seleoproteins in mammals and is one of the key regulators of ferroptosis, a form of regulated necrotic cell death 2.

      GPx displays an inverse correlation with free radicals and consequently oxidative stress (OS). When GPx activity is reduced, antioxidant protection is impaired, resulting in oxidative damage to the membrane fatty acids and functional proteins, resulting in neurotoxic damage. Decreased GPx activity and OS is implicated in the incidence and progression of several health problems, including: cardiovascular disease (CVD), diabetes, atherosclerosis, neurodegenerative disorders and other chronic conditions 3.

      Ransel Calibrator

      Ransel Control

      Reagents Home

      Reagents Resource Hub


      Non-Esterified Fatty Acids (NEFA) Assay

      Reagent | Non-Esterified Fatty Acid (NEFA)

      Non-Esterified Fatty Acid (NEFA): A Marker of Insulin Resistance

      Benefits of the Randox NEFA Assay

      Exceptional correlation

      A correlation coefficient of r=0.98 was displayed when the Randox NEFA assay was compared to commercially available methods.

      Applications available

      Applications available detailing instrument-specific settings for the convenient use of the Randox NEFA assay on a variety of clinical chemistry analsyers.

      Extensive measuring range

      The Randox NEFA assay has a measuring range of 0.072 – 2.24mmol/l for the comfortable detection of clinically important results.

      Standard supplied with the kit

      The Randox NEFA kit includes the standard simplifying the ordering process.

      Controls available

      Controls available offering a complete testing package.

      Excellent precision

      The Randox NEFA assay displayed a precision of <5% CV.

      Ordering information

      • Ordering Information
      Cat NoSize
      FA115R1 3 x 10ml (C)
      R2 3 x 20ml
      EnquireKit Insert RequestMSDSBuy Online
      (C) Indicates calibrator included in kit

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      • PHYSIOLOGICAL SIGNIFICANCE
      • Clinical Significance

      Non-esterified fatty acids are important metabolites stored in adipose tissue. NEFA turnover is swift, with a plasma half – life of 2 to 4 minutes. The dominant source of NEFA is abdominal subcutaneous fat, with considerably less found in leg adipose tissue and a small proportion found in the intraabdominal adipose tissue. NEFA has been recognised as a vehicle by which triacylglycerol (TG) (stored in the adipose tissue) is transported to its sites of utilisation 1. NEFA has been identified as the major source for skeletal muscle during fasting stages and long periods between meals. Cross – sectional studies have consistently documented that circulating NEFA levels are proportional to body fat storage and demonstrated positive correlations between fasting NEFA levels and obesity, insulin resistance and glucose tolerance 2.

      Non-esterified fatty acids concentrations are strongly associated with insulin resistance. In the fasting state, the resistance of adipose tissue to the antilipolytic effect of insulin causes the extensive release of NEFA into circulation. Consequently, elevated NEFA levels exacerbate insulin resistance through diminishing insulin – stimulated glucose intake into the skeletal muscle, directly affecting insulin signalling 3.

      Useful Links

      Clinical Chemistry Controls

      Clinical Chemistry EQA

      A-Z Reagents


      Request a meeting
      ×
      Make an Enquiry - RX series
      ×
      Make an Enquiry - Reagents
      ×
      Kit Insert Request - Reagents