Magnesium

Home - assay - Page 8

Magnesium

Reagent | Magnesium

Key Benefits

Excellent precision

The Magnesium assay showed a precision of less than 3% CV

Exceptional correlation

The Magnesium assay showed a correlation of r=0.99 against another commercially available method

Completely automated protocols

Are available for a wide range of analysers

Randox Magnesium (Xylidyl Blue and Methylthy. Blue)

  • Xylidyl Blue and Methylthy. Blue method
  • Liquid ready-to-use reagents
  • Stable to expiry when stored at +2 to +8⁰C

Ordering information

Cat NoSize
MG38806 x 20ml (L)EnquireKit Insert RequestMSDSBuy Online
MG81374 x 20ml (L)EnquireKit Insert RequestMSDSBuy Online
MG83262 x 16.5ml (L)EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Magnesium assay used for?

Magnesium is one of the major intracellular cations in the body. Its action is closely related to that of calcium. Magnesium deficiency, hypomagnesaemia can result in various neuromuscular disorders, weakness, tremors, tetany and convulsions. It is associated with hypocalcaemia, intravenous therapy, diabetes mellitus, alcoholism, dialysis and pregnancy.

Increased serum magnesium levels are associated with dehydration, severe diabetic acidosis and Addison’s Disease. Conditions that interfere with glomerular filtration as in renal failure result in retention of magnesium and hence elevation of serum levels.

Clinical Chemistry Panel

For more information or to view more reagents within the clinical chemistry panel, please click here

Veterinary Panel

For more information or to view more reagents within the veterinary panel, please click here


Lactate Dehydrogenase

Reagent | Lactate Dehydrogenase

Key Benefits

Excellent precision

The LD assay showed a precision of less than 4% CV

Exceptional correlation

The assay showed a correlation of r=0.98 against another commercially available method

Flexibility

Liquid and lyophilised reagents available, offering greater consumer choice

Randox Lactate Dehydrogenase L-P (LDH) (NAD)

  • LDH NAD method
  • Liquid ready-to-use reagents
  • Stable to expiry at 2-8°C
Cat NoSize
LD3842R1 6 x 20ml (L)
R2 3 x 18ml
EnquireKit Insert RequestMSDSBuy Online
LD8052R1 4 x 68ml (L)
R2 4 x 37.2ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Randox Lactate Dehydrogenase P-L (UV)

  • UV method
  • Liquid and lyophilised reagents available
  • Stable to expiry at 2-8°C
Cat NoSize
LD401R1a 1 x 70ml
R1b 20 x 3ml
EnquireKit Insert RequestMSDSBuy Online
LD3818R1 6 x 20ml (L)
R2 3 x 11ml
EnquireKit Insert RequestMSDSBuy Online
LD8051R1 6 x 56ml (L)
R2 6 x 20ml
EnquireKit Insert RequestMSDSBuy Online
LD8322R1 4 x 20ml (L)
R2 4 x 7ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Lactate Dehydrogenase assay used for?

Lactate dehydrogenase (LD) catalyses the interconversion of lactic acid and pyruvic acid. The enzyme is composed of 4 peptide chains and exists in 5 isomeric forms. LD is widely distributed throughout the body, and the highest concentrations are found in the liver, heart and skeletal muscle. LD activity is significantly elevated during myocardial infarction. Maximum levels are reached 24 to 48 hours after the onset of chest pain and may remain elevated for 7 to 12 days post infarction. Increases in LD activity are also associated with other pathological conditions including liver disease, progressive muscular dystrophy, megaloblastic and pernicious anaemia.

Publications


    Clinical Chemistry Panel

    For more information or to view more reagents within the clinical chemistry panel, please click here

    Veterinary Panel

    For more information or to view more reagents within the veterinary panel, please click here


    Lactate

    Reagent | Lactate

    Key Benefits

    Excellent stability

    Stable to expiry date when stored at +2 to +8°C

    Exceptional correlation

    The assay showed a correlation of r=0.99 against another commercially available method

    Lyophilised reagents

    The Randox L-Lactate assay is supplied in a lyophilised format, enhancing stability and reducing wastage

     

    Other features

    • Colorimetric method
    • Lyophilised reagents
    • Working reagent stable for 2 weeks at 15-25°C

    Ordering information

    Cat NoSize
    LC2389R1a 1 x 100ml (S)
    R1b 16 x 6ml
    EnquireKit Insert RequestMSDSBuy Online
    LC3980R1a 4 x 20.5ml
    R1b 4 x 20.5ml
    EnquireKit Insert RequestMSDSBuy Online
    (S) Indicates standard included in kit

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is Lactate assay used for?

    Increased concentration of lactate in the blood is an indicator of anaerobic metabolism i.e. blood flow to the tissues decrease and oxygen delivery is insufficient. In cases of severe oxygen deprivation “Lactic Acidosis” may occur. L-Lactate may therefore be used as an indicator of severity of circulatory failure.

    Clinical Chemistry Panel

    For more information or to view more reagents within the clinical chemistry panel, please click here

    Veterinary Panel

    For more information or to view more reagents within the veterinary panel, please click here


    Iron

    Reagent | Iron


    Key Benefits

    Excellent precision

    The Iron (ferene) assay showed a precision of less than 3.5% CV

    Exceptional correlation

    The assay showed a correlation of r=0.99 against another commercially available method

    Liquid and lyophilised reagents available

    Offering convenience and choice

    Randox Iron- Ferrozine

    • Ferrozine method
    • Liquid ready-to-use reagents
    • Stable to expiry when stored at 15-25⁰C
    Cat NoSize
    SI3821R1 6 x 20ml (L)
    R2 3 x 11ml
    EnquireKit Insert RequestMSDSBuy Online
    SI8049R1 7 x 15.5ml (L)
    R2 7 x 6.7ml
    EnquireKit Insert RequestMSDSBuy Online
    SI8330R1 4 x 20ml (L)
    R2 4 x 7ml
    EnquireKit Insert RequestMSDSBuy Online
    (L) Indicates liquid option

    Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

    What is Iron assay used for?

    Iron deficiency is one of the most prevalent human disorders. In adults iron deficiency is often symptomatic of chronic blood loss. Iron deficiency results in deficient haem synthesis with the subsequent symptoms of anaemia due to tissue hypoxia. Iron (non-heme) measurements are used in the diagnosis and treatment of diseases such as iron deficiency anaemia, hemochromatosis (a disease associated with widespread deposit in the tissues of two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of the skin), and chronic renal disease.

    Publications


      Clinical Chemistry Panel

      For more information or to view more reagents within the clinical chemistry panel, please click here


      Haemoglobin

      Reagent | Haemoglobin

      Key Benefits

      Applications available

      For a wide variety of clinical chemistry analysers

      Excellent stability

      The diluted reagent is stable for at least 6 months at +15°C to +25°C when stored in a tightly closed dark bottle

      Excellent linearity

      This method is linear up to 21 g/dl

      Other Features

      • Colorimetric method
      • Liquid reagents
      • Stable to expiry when stored at 2-8⁰C
      • Excellent linearity up to 21 g/dl
      • No extraction needed with whole blood application
      • For manual use only

      Ordering Information

      Cat NoSize
      HG15395 x 100ml (L)EnquireKit Insert RequestMSDSBuy Online
      (L) Indicates liquid option

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      What is Haemoglobin assay used for?

      Haemoglobin measurement is part of the full blood count which is requested when a doctor suspects an illness related to above or below normal levels. Haemoglobin levels are also measured:

      • before operations to make sure the patient is fit for surgery
      • to detect and measure the severity of anaemia or polycythaemia
      • to monitor response to treatment
      • to help make decisions about blood transfusions

      Related Products

      Clinical Chemistry Panel

      For more information or to view more reagents within the clinical chemistry panel, please click here


      Glycerol

      Reagent | Glycerol

      Key Benefits

      Applications available

      For a wide variety of clinical chemistry analysers

      Exceptional correlation

      The Glycerol assay showed a correlation of r=0.999 against another commercially available method

      Limited interference

      Ascorbic Acid up to a concentration of 400 µmol/l will not affect this test

      Other Features

      • GPO-PAP method
      • Lyophilised reagents
      • Working reagent stable for 14 days when stored at 2-8⁰C or 3 days at 15-25°C
      • Measuring range 14.5 – 2545 µmol/l
      • For manual or semi-automated use only
      Cat NoSize
      GY1056x 15ml (S)EnquireKit Insert RequestMSDSBuy Online
      (S) Indicates standard included in kit

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      What is Glycerol assay used for?

      Glycerol measurements are used in the diagnosis and treatment of patients with diabetes mellitus, nephrosis, liver obstruction, other diseases involving lipid metabolism, or various endocrine disorders.

      • Beatty, O.L. Insulin resistance in offspring of hypertensive parents. BMJ 1993, 307(6896): 92-96
      • Ranganath, L., et al. The effect of circulating non-esterified fatty acids on the entero-insular axis. European Journal of Clinical Investigation. 1999, 29(1): 27-32
      • McTernan, P.G., et al. Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro. Diabetes2002, 51(5): 1493-1498
      • Lutoslawska, G., et al. Relationship between fasting insulin resistance index (FIRI) and plasma glycerol and free fatty acid levels in physically active males and females. Biol. Sport 2006, 23: 341-351
      • Kos, K., et al. Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass. Am. J. Physiol. Endocrinol. Metab. 2007, 293: E1335-E1340
      • Rhodes, P., et al. Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PloS ONE 2009, 4(10): e7393

      Related Products

      • Glycerol Controls

      Standard included in the kit

      Clinical Chemistry Panel

      For more information or to view more reagents within the clinical chemistry panel, please click here


      GLDH

      Glutamate Dehydrogenase (GLDH)

      Key benefits of the Randox Glutamate Dehydrogenase (GLDH) reagent

      Lyophilised Reagents

      The Randox GLDH (DGKC) assay is lyophilised for enhanced stability

      Exceptional correlation

      The GLDH (DGKC) assay showed a correlation of r=0.99 against another commercially available method

      Stability

      Open vial stability of 1 week at+2oC to +8oC.

      Ordering information

      Cat NoSize
      GL441R1a 1 x 70ml
      R1b 8 x 6ml
      R2 2 x 20ml
      EnquireKit Insert RequestMSDSBuy Online
      GL442R1a 5 x 100ml
      R1b 5 x 100ml
      R2 2 x 20ml
      EnquireKit Insert RequestMSDSBuy Online

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      What is GLDH assay used for?

      GLDH measurements can be taken to evaluate the liver function. Elevated blood serum levels indicate liver damage. GLDH also plays an important role in the differential diagnosis of liver disease, especially in combination with aminotransferases.

      Liver diseases such as toxic liver damage or hypoxic liver disease are characterised by high serum levels. In clinical trials, GLDH can also be used as a measurement for the safety of a drug.

      The Randox GLDH is an optimised standard method according to the recommendations of the Deutsche Gesellschaft für Klinische Chemie. This procedure measures the non specific creep reaction.

      Clinical Chemistry Panel

      For more information or to view more reagents within the clinical chemistry panel, please click here

      Veterinary Panel

      For more information or to view more reagents within the veterinary panel, please click here


      Gamma GT

      Reagent | Gamma GT

      Benefits of the Gamma GT Assay

      Exceptional correlation

      The assay showed a correlation of r=0.99 against another commercially available method

      Excellent stability

      Stable to expiry when stored at 2-8⁰C

      Liquid ready-to-use

      The Randox Gamma GT reagent is available in a liquid ready to use format for convenience and ease of use.

      Randox Gamma GT (Colorimetric)

      • Colorimetric method
      • Liquid ready-to-use reagents
      • Stable to expiry when stored at 2-8⁰C

      Ordering Information

      Cat NoSize
      GT3817R1 6 x 51ml (L)
      R2 6 x 14ml
      EnquireKit Insert RequestMSDSBuy Online
      GT38746 x 21ml (L)EnquireKit Insert RequestMSDSBuy Online
      GT8320R1 4 x 20ml (L)
      R2 4 x 7ml
      (Mod. IFCC)
      EnquireKit Insert RequestMSDSBuy Online
      GT8146R1 7 x 20ml (L)
      R2 7 x 8ml
      EnquireKit Insert RequestMSDSBuy Online
      (L) Indicates liquid option

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      What is Gamma GT assay used for?

      Gamma-glutamyltransferase (GT) in serum originates primarily from the hepatobiliary system. Therefore GT is elevated in all forms of liver disease and has been shown to be more sensitive than alkaline phosphatase in detecting obstructive jaundice, cholangitis and cholecystitis. High levels of GT are also seen in patients with primary or secondary liver cancer. Increased levels are also observed in cases of alcohol abuse and in alcoholic liver cirrhosis. In patients receiving anticonvulsant drugs such as phenytoin and phenobarbital, increased levels of the enzyme in serum may reflect induction of new enzyme activity and the toxic effects of alcohol and other drugs on the microsomal structures in liver cells. GT is the most sensitive enzymatic indicator of hepatobiliary disease, and can be used in combination with other biochemical markers to discriminate between different types of hepatobiliary disease.

      • Haçariz, O. et al. The effect of Quil A adjuvant on the course of experimental Fasciola hepatica infection in sheep. Vaccine 2009, 27(1): 45-50
      • Haçariz, O. et al. IL-10 and TGF-β1 are associated with variations in fluke burdens following experimental fasciolosis in sheep. Parasite Immunol. 2009, 31(10): 613-622
      • Gbadegesin, M.A., et al. In vitro antioxidant/radical scavenging activities and hepatoprotective roles of ethanolic extract of Cassia occidentalis leaves in sodium arsenite-treated male Wistar rats. Br. J. Med. Med. Res. 2013, 3(4): 2141-2156

      Clinical Chemistry Panel

      For more information or to view more reagents within the clinical chemistry panel, please click here

      Veterinary Panel

      For more information or to view more reagents within the veterinary panel, please click here


      CO2 Total Reagent

      Reagent | CO2 Total

       

      Key Benefits of the Randox CO2 Total Reagent

      Exceptional correlation with standard methods

      The Randox methodology was compared against other commercially available methods and the Randox CO2 Total assay showed a correlation coefficient of r=0.94

      Wide measuring range

      The healthy range for CO2 Total is 18 – 28 mmol/l. The Randox CO2 Total assay can comfortably detect levels outside of this healthy range measuring between 0.004 – 50 mmol/l

      Suitable for use on a range of automated analysers

      The Randox CO2 Total reagent is suitable for use on a number of third party automated analysers. To enquire about an Instrument Specific Application (ISA), please click the Contact Us button below.

      Other features

      • Enzymatic method
      • Liquid ready-to-use reagent
      • Stable until expiry date when stored at +2 to +8°C
      • Open vial stability of 14 days at +10°C
      • Measuring range 0.004 – 50 mmol/l

      Ordering information

      Cat NoSize
      CD40064 x 21.7ml (C)(L)EnquireKit Insert RequestMSDSBuy Online
      (L) Indicates liquid reagent
      (C) Indicates calibrator included in kit

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      What is CO2 Total used for?

      Carbon dioxide (CO2) is a metabolic waste product of cellular respiration. It is transported in the bloodstream to the lungs and expelled from the body. CO2 exists in the body in two forms: 90% exists as bicarbonate (HCO3) and the remaining exists as carbonic acid (H2CO3) or dissolved CO2. The kidneys and lungs are responsible for the regulation on CO2, H2CO3 and HCO3 in the blood.

      What is the CO2 Total assay used for?

      The Randox CO2 Total assay is used for the quantitative in vitro determination of CO2 in serum and plasma.  It aids in diagnosing diseases associated with high and low levels of CO2 in the bloodstream.

      Slightly elevated levels of CO2 do not have any serious consequences on the body, but overexposure to CO2 due to decreased alveolar ventilation or the inhalation of CO2 enriched air can cause serious implications in the body including: deterioration of respiratory functions due to respiratory acidosis and asphyxiation, cardiovascular effects due to low blood pressure and cardiac arrhythmia and nerve damage due to hypercapnia and acidemia.

      For more information on the contrasting effects of hypoxia and hypercapnia, please click here.

      High CO2 levels usually indicates that the lungs are not functioning properly and are unable to expel the required amount of CO2. During an acute illness, the levels of CO2 can increase suddenly, however, over time, some people are able to establish a new ‘baseline’ for CO2. An example of this is a person with stable chronic obstructive pulmonary disease (COPD) This means that the body is able to function with higher than normal levels of CO2.

      There are some medical conditions and drugs that can cause low CO2 levels including: kidney disease as the kidneys are unable to carry out their functions, diabetic ketoacidosis due to the production of ketones resulting in reduced CO2 levels, hyperchloremic acidosis due to diarrhea, Addison’s disease, and metabolic acidosis due to chemical toxicity.

      Clinical Chemistry Panel

      For more information or to view more reagents within the clinical chemistry panel, please click here

      Veterinary Panel

      For more information or to view more reagents within the veterinary panel, please click here


      Zinc Assay

      Reagent | Zinc


      Benefits of the Randox Zinc Assay

      Excellent correlation

      A correlation coefficient of r=0.9946 was displayed when the Randox method was compared against other commercially available methods.

      Excellent precision

      The Randox zinc assay displayed a within run precision of <3.87%.

      Liquid ready-to-use

      The Randox zinc assay is available in a liquid ready-to-use format for convenience and ease-of-use.

      Standard supplied with the kit

      The standard is supplied with the zinc kit, simplifying the ordering process.

      Controls available

      Controls available offering a complete testing package.

      Applications available

      Applications available detailing instrument-specific settings for the convenient use of the Randox zinc assay on a variety of clinical chemistry analysers.

      Ordering Information

      Cat NoSize
      ZN2341R1 1 x 50ml (S) (L)
      R2 1 x 250ml
      with Deproteinisation
      EnquireKit Insert RequestMSDSBuy Online
      ZN26076 x 50ml (L)
      Deproteinising Solution
      EnquireKit Insert RequestMSDSBuy Online
      (L) Indicates liquid option
      (S) Indicates standard included in kit

      Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

      Physiological Significance

      Zinc (ZN) is an essential trace element (micronutrient) and plays a vital role in several biological processes 1. ZN is released from food as free ions during digestion. Specific transport proteins facilitate the passage of ZN across cell membranes into circulation. 70% of circulatory ZN is bound to albumin 2. As ZN does not attain redox properties, it is capable of transportation around the biological systems without inducing oxidative damage, which can occur with other essential trace elements like copper 3.

      ZN has a key role in growth, reproduction, sexual maturity and the immune system. ZN is vitally important in the functionality of >300 enzymes utilised in the stabilisation of DNA and gene expression 1. ZN can constitute strong, yet readily available flexible and exchangeable, complexes with organic molecules, enabling it to modify the three-dimensional structure of specific proteins, nucleic acids, and cellular membranes, thereby influencing the catalytic properties of many enzyme systems and intracellular signalling. ZN is associated with >50 metalloenzymes with a diverse range of functions and so ZN plays a central role in metabolism, differentiation and cellular growth 3.

      Deficiency

      Zinc deficiency has been identified as a malnutrition issue worldwide. ZN deficiency is more prevalent in areas of low animal consumption and high cereal consumption. It’s not that the diet is low in ZN but more so the bio-availability of ZN which plays a major role in its absorption. Phytic acid has been identified as the main inhibitor of ZN. Adolescents, children, infants, lactating women and pregnant women have increased requirements for ZN and so are at higher risk of zinc depletion. During growth periods, ZN deficiency causes growth failure. The organs most affected by ZN deficiency include: central nervous system, epidermal, gastrointestinal, immune, reproductive and skeletal systems 2.

      Toxicity

      As there are multiple sources of ZN in the environment, exposure to and toxicity from ZN are not uncommon. Case reports have documented zinc toxicity caused by: overuse of dietary supplements, inhalation from occupational sources, denture cream and ingestion of pennies, to which some of these cases had fatal outcomes 4.

      It is believed that ZN toxicity from acute exposure differs significantly from chronic toxicity. In acute exposures, ingestions of ZN sulfate and concentrated ZN chloride will primarily result in gastrointestinal symptoms, such as haematemesis. Renal injury, liver necrosis, coagulopathy and even death have been reported following acute exposures 4.

      Chronic exposure caused by excessive consumption of ZN, resulting in copper deficiency can lead to myelodysplastic syndrome, granulocytopenia and sideroblastic anaemia 4.

      Publications


        Clinical Chemistry Calibrator

        Clinical Chemistry Control

        Clinical Chemistry EQA