#LoveYourHeart this Valentine’s Day!

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#LoveYourHeart this Valentine’s Day!

We are encouraging you to #LoveYourHeart this Valentine’s Day! Read on to find out why your heart health should matter to you this #HeartMonth!

Fact:  Did you know people with diabetes are 2 to 4 times more likely to develop cardiovascular disease than people without diabetes?¹

Good diabetes control is imperative!  If you have diabetes take control and monitor your treatment to ensure you are safe from complications such as cardiovascular disease…

Many complications associated with diabetes include kidney disease, eye disease, cardiovascular disease and diabetic ketoacidosis (a life threatening condition that can develop in insulin dependent diabetics).

If you have diabetes, being physically active and controlling your weight and blood pressure will help manage your blood sugar level; and therefore help manage the risk of cardiac diseases.

However a few simple routine tests may also be carried out to ensure normal kidney function.  Normal kidney function in a diabetic patient means that diabetes is being controlled well, however if kidney function begins to deteriorate then you will know that measures need to be taken to control diabetes better.

Speciality tests to assess kidney function which can be requested include:

  • Cystatin C a sensitive marker of kidney function used for detection of early renal dysfunction in diabetic patients. It is important to note that Creatinine is the routine test for renal dysfunction, however it has a blind range which means it is unable to detect elevated Creatinine levels found in stage 2 and halfway through stage 3 renal dysfunction; as a result 50% of kidney function can be lost before elevated Creatinine levels can be seen. The Cystatin C test is a much more sensitive marker and can detect early stages of renal dysfunction, allowing treatment to begin before it is too late.
  • Beta-2 Microglobulin – this test is used when kidney damage has occurred to distinguish between the two most commonly affected sites, glomeruli and renal tubules.

Fact:  Cardiovascular Diseases are the number one cause of death globally, with more people dying annually from CVDs than any other cause.²   In the UK alone, 41,000 people under the age of 75 die from CVD each year.³

If you are worried about your cardiovascular health, or whether you are at risk of a heart attack or stroke, ask your doctor for a cardiovascular risk assessment. Routinely they will run lipid tests such as Total Cholesterol, HDL Cholesterol, LDL Cholesterol and Triglycerides to assess your overall cholesterol and triglyceride levels, and allow corrective action to be taken.

Look out for hidden risk factors!

Specific tests you may also want to discuss with your doctor include:

  • sLDL Cholesterol and Lipoprotein(a) to assess for genetically inherited risks of cardiovascular disease – even if your cholesterol levels are safe you may still be at risk of cardiovascular disease as a result of familial traits
  • Adiponectin to assess the level of abdominal visceral fat, of which high levels can increase your cardiovascular risk. Please note that abdominal visceral fat levels or body fat cannot be determined by BMI score, which assesses whether weight is within a healthy range. As such, the Adiponectin test provides a clearer indication of health and is a good predictor of cardiovascular risk
  • TxBCardio to assess response to Aspirin therapy for the prevention of cardiovascular disease. Up to 30% of patients receiving Aspirin therapy suffer unknowingly from Aspirin resistance. This test enables treatment to be modified and corrected

Asking your doctor for these tests creates an opportunity for corrective action to be taken and can have significant benefits for your health.

Fact:  Approximately one woman dies from heart disease every minute, of which 64% had no previous symptoms.4

Sixty-four percent of women who die suddenly of coronary heart disease had no previous symptoms. Because these symptoms vary greatly between men and women, they’re often misunderstood. Media has conditioned us to believe that the telltale sign of a heart attack is extreme chest pain. But in reality, women are somewhat more likely to experience shortness of breath, nausea/vomiting and back or jaw pain. Other symptoms women should look out for are dizziness, lightheadedness or fainting, pain in the lower chest or upper abdomen and extreme fatigue.

Being aware of these signs can aid early detection, and greatly increase chances of surviving a heart attack!

 

So don’t forget to #LoveYourHeart this Valentine’s Day!  Randox can provide a vast range of specialised blood tests to allow the most accurate diagnosis of diabetes, cardiac risk and associated complications. From all of us here at Randox we wish you an enjoyable Valentine’s Day!

For health professionals:

Randox Laboratories manufacture a wide range of routine and niche biochemistry reagents suitable for both research and clinical use.  These include a wide variety of automated routine and niche diabetes and cardiac tests and our new HDL3-C assay.  Please contact reagents@randox.com for further information.

 

References

  1. World Heart Federation, Diabetes, https://goo.gl/e8WG86 Accessed: February 2017
  2. WHO, Cardiovascular diseases (CVD), https://goo.gl/fGO0bj, (2016), Accessed: February 2017
  3. British Heart Foundation, CVD Statistics – BHF UK Factsheet, https://goo.gl/6DEOdw (2017), Accessed: February 2017
  4. Reference: American Heart Association, Common Myths About Heart Disease, (2017),  https://goo.gl/NEz5gV, Accessed: February 2017

 

Further reading:


Does Your QC Cover Clinically Relevant Ranges?

Following recommendations from recognized institutions such as ISO and CLIA, more laboratories are using third party controls than ever before. However, great care should be taken when choosing which third party control to use. A number of factors should be considered, and primarily among these is whether the control challenges the complete Clinical Range and the Medical Decision Levels. ISO 15189:2012 states that ‘The laboratory should choose concentrations of control materials wherever possible, especially at or near clinical decision values, which ensure the validity of decisions made’.

Measuring the Complete Clinical Range

It is important to assess the full clinical range of an assay i.e. the range between the lowest and highest results which can be reliably reported. In order to make sure a laboratory instrument is working across the full clinical range, a QC which covers low, normal and elevated concentrations must be used.

Question: “If the full clinical range isn’t covered by QC, how will we know whether patient results which fall outside the range of quality controls are accurately reported?”

What are Medical Decision Levels?

Medical Decision Levels (MDL) are the analyte values at which medical professionals can determine whether a patient may be suffering from a certain condition. The MDL is determined by a consensus of medical professionals and clinical research. Patients’ test results are compared to the MDL and appropriate diagnoses or medical interventions can be made.

For example, the MDL of Glucose can indicate a certain diabetic status:

AnalyteMedical Decision LevelDiagnostic Status
Glucose (fasting)<100 mg/dLNon-Diabetic
100–125 mg/dLPre-Diabetic
>125 mg/dLDiabetic

Competitor QC

Many QC manufacturers ‘cut corners’ in an attempt to keep costs down, which often results in the sale of controls which do not cover the complete clinical range or vital medical decision levels. Below is an example of the Glucose concentrations present in a competitor control:

Competitor Chemistry Control Level 1 – 68 mg/dL

Competitor Chemistry Control Level 2 – 134 mg/dL

Competitor Chemistry Control Level 3 – 386 mg/dL

In the examples above, the competitor’s level 1 control covers the non-diabetic MDL, but the level 2 control is not within the ‘Pre-Diabetic’ decision range. The level 3 control is also much higher than can be expected for an elevated diabetic patient result (200 mg/dL or more).

Randox QC

Due to the superior manufacturing process used by Randox, QC target values are consistently within the MDL of tests. For example, the Glucose concentrations present in our Liquid Assayed Chemistry Premium Plus control are:

Level 1 – 57 mg/dL

Level 2 – 114 mg/dL

Level 3 – 236 mg/dL

The MDL for Glucose is covered by the Randox control, meaning laboratory professionals can be confident that patient results will be accurately interpreted.

Immunoassay Medical Decision Levels

Controls which cover the MDL can reduce the number of Quality Controls required by laboratories. For example, Randox Acusera Lyophilised Immunoassay Controls contain particularly low levels of TSH, Ferritin and Vitamin B12 in the Level 1 control, eliminating the need for an additional control at extra expense:

AnalyteMedical Decision LevelRandox Level 1 IA ControlCompetitor Level 1 IA Control
TSH0.1 or 0.27 uU/mL0.15uU/mL0.37 uU/mL
Vitamin B12190 pmol/L174 pmol/L327 pmol/L
Ferritin12 ng/mL11.1 ng/mL49.6 ng/mL

In this example the competitor offers an anaemia control with lower levels of TSH, Vitamin B12 and Ferritin at an additional cost. With Randox Acusera QC, only one control is required for anemia monitoring and detection.


Careers Tips | 5 Reasons You’ll Love Working at Randox

Are you thinking of working at Randox? Great! Whether you’re from a science background, business, or art, Randox embrace multiple disciplines and we, at Randox Careers, are here to give you 5 reasons why you’ll love working with us!


1. Company Culture

Randox have built a team of the most passionate, inspiring and motivated individuals in the industry. Employees of Randox aren’t just a team, but they’re family!

Randox Laboratories likes to celebrate talent, and encourages people to work to their strengths, as recently demonstrated in the largely successful Future in the Making event, which was held to gather and thank Randox employees worldwide for the success of the growth of the company. Randox encouraged employees to share their experiences through the hashtag #WeAreRandox. Check it out, here!

2. Learning Opportunities are Endless!

Due to the size of Randox, and the vast specialties in the health sector, Randox Laboratories has a lot to offer in teaching new, innovative techniques in business, science, design, technology, engineering, and many more!

Randox is a great place to be given the opportunity to get creative in your industry! Work is always fast-paced, forward-thinking and open to fresh, innovative ideas! Peter FitzGerald (Randox Founder & MD) stated “We never stand still here! Our mission is to transform healthcare by continuously improving diagnostic solutions, which, for us, ultimately means saving lives.”

Randox Laboratories is not only a great place to grow, develop and climb the career-ladder whilst in full-time work, but it encourages growth in students, too! Renowned for their highly active Placement programs for 1st and 2nd year students, Randox offers 50+ positions each year for every sector. We hold a special awards ceremony for our highest achieving students at the end of the year, commending them for their outstanding work at Randox! You can read about the Pinnacle Placement Awards and see this year’s winners here.

3. Randox is a Globally Respected Brand

Working for a company like Randox will prove your ambition to individuals in every industry globally. We understand your CV is very important to you, and having worked for a well-respected brand like Randox,  you’re sure to stand out from the crowd!

4. Be a Jet-setter! 

Randox has a large global presence. With offices in over 145 countries, we are frequently attending high profile events in such places as Dubai, Thailand, London, USA, and Paris! (You can check out some of our upcoming events, here.)

You can have the opportunity to experience these beautiful countries with Randox!

5. Let Your Work Change The World

Randox is an influential company and a global leader in the Healthcare and Diagnostics industry, responsible for diagnosing 5% of the population’s conditions. We are dedicated to improving the healthcare industry, and saving lives with our hard work. Randox’s success means better quality of life for the global population, as we discover how to diagnose as early as possible.

Do you want to change the world with us? Join the team, check out our opportunities!

Reasons you'll love working at randox laboratories diagnostics
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