Reagent | Homocysteine
A Marker of Hyperhomocysteinemia
Benefits of the Randox Homocysteine Assay
Two-part liquid ready-to-use
The Randox homocysteine assay is available in a two-part liquid ready-to-use format, limiting interference from bilirubin, haemoglobin, triglycerides and intralipid®, producing more accurate and precise results.
The Randox homocysteine assay is standardised to the NIST SRM 1955 (Homocysteine Standard Reference Material) displaying a correlation coefficient of r=0.98 when compared to industry comparative methods.
Excellent measuring range
The Randox homocysteine assay has a measuring range of 1.7 – 47.9 μmol/l for the comfortable detection of clinically important results.
Calibrator included in the kit
The Randox homocysteine kit includes the calibrator simplifying the ordering process.
Controls available offering a complete testing package.
Applications available detailing instrument-specific settings for the convenient use of the Randox homocysteine assay on a variety of clinical chemistry analysers.
Homocysteine is a sulfur-containing amino acid produced by the intracellular demethylation of the essential amino acid, methionine. Homocysteine has three metabolic functions within the human body: firstly, to be remethylated into methionine; secondly, to enter the biosynthetic pathway of cysteine; and thirdly, to be released into the extracellular medium (blood and urine). The third metabolic function is the direct cause of elevated homocysteine concentrations in urine and plasma 1, 2.
Hyperhomocysteinemia (elevated levels of homocysteine) has been identified in numerous conditions and disease states including, cardiovascular disease (atherosclerosis and thrombosis), pregnancy complications, psoriasis, cognitive impairment in the elderly, mental disorders, neural tube defects and birth defects 1, 2.
Women with elevated levels of homocysteine have a 3-fold increased risk of CVD, whereas men have a 2-fold increased risk 3. Hyperhomocysteinemia correlates with an increased risk of colorectal cancer with elevated homocysteine levels being highly prevalent in patients with inflammatory bowel diseases which is believed to be associated with either an increased or decreased absorption of folate and other B vitamins 4. Hyperhomocysteinemia was associated with a 2 to 3-fold increased risk of abrupyio placentae, pregnancy-induced hypertension, and intrauterine growth restriction 5.
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 Steegers-Theunissen RP, Van Iersel CA, Peer PG, Nelen WL, Steegers EA. Hyperhomocysteinemia, pregnancy complications, and the timing of investigation. Obstetrics and Gynecology 2004; 104(2): 336-343.