AST Assay

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AST Assay

Aspartate Aminotransferase (AST)

A Marker of Hepatocellular Injury

Benefits of the Randox AST Assay

Precision

Excellent precision

The Randox AST assay displayed a within run precision of < 4.96%.

Wide measuring range

Wide measuring range

The Randox AST assay has a measuring range of 4.42 – 657U/l for the comfortable detection of clinically important results.

Excellent stability

The Randox AST assay is stable to expiry when stored at +2oC to +8oC.

Liquid ready-to-use

Liquid ready-to-use

The Randox AST assay is available in a liquid ready-to-use format for convenience and ease-of-use.

Calibrator and controls available

Calibrator and controls available offering a complete testing package.

Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox AST assay on a variety of clinical chemistry analysers.

  • Ordering Information
  • PHYSIOLOGICAL SIGNIFICANCE
  • Hepatic Function
  • Muscular Dystrophy
  • COVID-19
Cat NoSize    
AS3804R1 6 x 51ml (L)
R2 6 x 14ml
EnquireKit Insert RequestMSDSBuy Online
AS101R1 1 x 100ml (L)
R2 1 x 100ml
(Colorimetric, manual only)
EnquireKit Insert RequestMSDSBuy Online
AS8005R1 6 x 56ml (L)
R2 6 x 20ml
EnquireKit Insert RequestMSDSBuy Online
AS8306R1 4 x 20ml (L)
R2 4 x 7ml
EnquireKit Insert RequestMSDSBuy Online
AS120410 x 10mlEnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option (S) Indicates standard included in kit

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Enzymes are organic molecules responsible for the acceleration of biochemical reactions, however, emerge unchanged following the reaction. Aminotransferases are a family of enzymes that catalyse the conversion of amino acids to 2-oxo-acids by the transfer of amino acids 1. AST is present in mitochondrial and cytosolic enzymes (80% and 20% of activity respectively), found in brain, cardiac muscle, kidneys, leucocytes, liver, lungs, red blood cells and skeletal muscle 2.

AST is a marker of hepatocellular injury, predominantly alcohol-related liver injury (chronic hepatitis C) and cirrhosis (chronic hepatitis B). In alcoholic liver disease, P-5-P becomes deficient, which is greater on ALT activity compared to AST activity. Consequently, ALT activity is reduced, whereas AST activity is increased 2. The hallmark finding for alcohol liver disease is the AST to ALT ratio of at least 2:1 3. The marked laboratory findings for ischaemic hepatitis is an elevated bilirubin level, however, AST levels are > 10 times the upper reference range limit 2. Acute viral hepatitis, drug or toxin induced liver disease and ischaemic liver injury are characterised by extremely elevated aminotransferase levels 3.

Muscular dystrophy, including Duchenne muscular dystrophy is characterised by hypertransaminasemia. Elevations in both ALT and AST are most striking in the early stages of muscular disease, prior to the onset or only when subtle symptoms are present. Consequently, during these initial stages, ALT/AST testing can enable the early identification of disease and so the early intervention of treatment plans 4.

The diagnosis of liver disease in COVID-19 patients can be challenging for the clinician. There is often uncertainty as to whether there was a pre-existing undiagnosed liver disease. Also, many medications utilised to treat moderate and severe disease have their own profiles of liver toxicity. Elevations of aminotransferase is the most common abnormality in patients presenting with COVID-19. It was identified that AST is more frequently elevated in comparison to ALT 5. AST showed statistically significant elevations in severe COVID-19 in comparison to mild cases 6.

Want to know more?

Contact us or download the reagents brochure to learn more.

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Albumin Assay

Albumin

A Marker of Hepatic Dysfunction

Benefits of the Randox Albumin Assay

Wide measuring range

Exceptional measuring range

The Randox albumin assay has a measuring range 2.87 – 75.5g/l for the comfortable detection of clinically important results.

Precision

Excellent precision

The Randox albumin assay displayed a within run precision of < 1.97%.

Stable to expiry date

Stable to expiry date when stored at +15oC to +25oC.

Liquid ready-to-use

Liquid ready-to-use

Available in a liquid ready-to-use format for convenience and ease-of-use.

Calibrator and controls available

Calibrator and controls available for a complete testing package.

Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox albumin assay on a variety of clinical chemistry analysers.

  • Ordering Information
  • PHYSIOLOGICAL SIGNIFICANCE
  • MORTALITY
  • DIABETES
  • HEPATIC FUNCTION
  • COVID-19

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Albumin is the most abundant circulating protein found in plasma, representing approximately half of the total protein content in health human plasma. Synthesised by liver hepatocytes, it is rapidly excreted into the bloodstream, approximately 10gm – 15gm per day, with little remaining in the liver 1. It is responsible for the maintenance of colloidal osmotic pressure, provision of the majority of plasma antioxidant activity, and the binding of a variety of compounds 2.

A correlation between serum albumin concentrations and ill-health has been identified, with an astonishingly strong inverse correlation between serum albumin and mortality risk 2. The association of it with other confounding variables increase mortality (fig 1). The concentration is related to the rates of synthesis and catabolism, but also influenced by state of hydration, lymphatic return, external losses (burns), and rates of transcapillary escape. In starvation, both the synthesis and catabolism fall, whereas in nephrotic syndrome, synthesis rises and catabolism falls 3.

Fig. 1. Potential associations between serum albumin and mortality 3
Fig. 1. Potential associations between serum albumin and mortality

A direct, casual relationship between serum albumin and mortality is represented by arrow a or the sequence b, a. A non-casual, confounding relationship is represented by arrows b and c. A co-causal relationship is represented by arrows a and c.

Low circulating albumin is associated with an adverse metabolic profile characterised by increased adipose tissue inflammation, glucose concentrations, and adiposity. It inversely correlates with type 2 diabetes mellitus (T2DM) risk 4. Moreover, serum albumin concentrations are inversely correlated with the risk of ketosis in hospitalised patients with T2DM and may require the early initiation of insulin therapy to prevent complications. It is a promising prognostic marker in hospitalised diabetic patients with acute hyperglycaemia 5.

Low levels of serum albumin is common in cirrhosis and is associated with a reduced survival rate. In this setting, the native isoform can be severely reduced as a result of several post-transcriptional changes that impair the non-oncotic properties of the molecule 6.

Hypoalbuminemia status has been associated with the critically ill and mortality across several clinical settings. Hypoalbuminemia can potentially lead to the early recognition of severe disease associated with COVID-19 and can assist clinicians in making informed decisions for their patients 7.

Want to know more?

Contact us or download the diabetes portfolio brochure to learn more.

Related Products

Clinical Chemistry Calibrator

Clinical Chemistry Control

Clinical Chemistry EQA

Reagents Resource Hub


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