Apolipoprotein A-II

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Apolipoprotein A-II

Reagent | Apolipoprotein A-II

Key benefits of the Randox Apolipoprotein A-II reagent

Exceptional measuring range

The Randox albumin assay has a measuring range 6.75-61.1 mg/dl for the comfortable detection of results.

Excellent stability

Stable to expiry when stored at 2-8°C

Liquid ready-to-use reagents

The Randox Apolipoprotein A-II reagent comes in a liquid format which is more convenient, and can also help reduce the risk of errors occurring

Applications available

Applications available detailing instrument-specific settings for a variety of clinical chemistry analysers.

Ordering information

Cat NoSize    
LP3867R1 2 x 11ml
R2 2 x 5ml
EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Apolipoprotein A-II assay used for?

Apolipoproteins are proteins on the surface of the lipoprotein complex that bind to specific enzymes or transport proteins on the cell membranes. This directs the lipoprotein to the proper site of metabolism. APO A-II is mainly created in the liver and modulates lipoprotein lipase and hepatic triglyceride lipase. It also acts as a co-factor for Lecithin Cholesterol Acyltransferase which is involved in lipoprotein processing.

Apolipoprotein A-II is a major constituent of High Density Lipoprotein (HDL) particles and plays an important role in the reverse cholesterol transport and lipid metabolism. The APO A-II test can be used as an aid in assessing the risk of CVD.


5th Generation Bile Acids Assay

5th Generation Bile Acids

A Superior Method for Intrahepatic Cholestasis of Pregnancy (ICP) Testing

Benefits of the Randox 5th Generation Bile Acids Assay

Superior Performance

Superior methodology

Utilising the advanced enzyme cycling method, the Randox 5th generation bile acids assay displayed outstanding sensitivity and precision when compared to the traditional enzymatic based tests.

 

Measuring range

Excellent measuring range

The Randox 5th generation bile acids assay has a measuring range of 2.16 – 238µmol/l for the comfortable detection of clinically important results.

 

Correlation

Exceptional correlation

A correlation coefficient of r=0.99 was displayed when the Randox method was compared against other commercially available methods.

 

Liquid ready-to-use

Liquid ready-to-use

The Randox 5th generation bile acids is available in a liquid ready-to-use format for convenience and ease-of-use.

 

Calibrator & Controls

Calibrator and controls available

Calibrator and controls are available offering a complete testing package.

 

Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox 5th generation bile acids assay on a variety of clinical chemistry analysers.

 

A 4th generation method for bile acids testing is also available which offers an excellent linearity up to 150µmol/l. Applications available detailing instrument-specific settings for the convenient use of the Randox 4th generation bile acids assay on a variety of clinical chemistry analysers.

 

  • Ordering Information
  • INTRAHEPATIC CHOLESTASIS OF PREGNANCY
  • TRADITIONAL DIAGNOSTIC TESTING
  • THE FIFTH GENERATION TEST
Cat NoSize    
BI7982R1 6 x 50ml
R2 6 x 18ml
EnquireKit Insert RequestMSDSBuy Online
BI3863R1 2 x 18ml
R2 2 x 8ml
EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Intrahepatic cholestasis of pregnancy (ICP) or obstetric cholestasis is a pregnancy-specific liver disorder. ICP, characterised by maternal pruritus in the absence of a rash and increased total bile acids (TBA) levels, is a severe form, yet reversible, cholestasis commonly occurring in the second and third trimester of pregnancy. Diagnostic and therapeutic guidelines are lacking for ICP which is of concern as ICP can have significant foetal risks 1, 2.

ICP restricts the flow of bile through the gallbladder causing bile acids to build-up in the liver 2. Due to the build-up, bile acids leak into the bloodstream where they are detected at concerning levels.  It has been documented that TBA levels in ICP can reach as high as 100 times the upper limit of a normal pregnancy. Moreover, a doubling in maternal serum TBA levels, results in a 200% increased risk of stillbirth. Additionally, elevated serum bile acids can affect the foetal cardiovascular system causing issues such as cardiac rhythm disturbances 3.

Whilst other liver function tests exist, including: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT) and bilirubin; TBA testing is thought to be the most beneficial method for the diagnosis and monitoring ICP. Moreover, TBA measurements are believed to be the most beneficial when tested in conjunction with standard liver tests, offering unrivalled sensitivity enabling the identification of early stage hepatic dysfunction 3.

The enzyme cycling method enables signal amplification through cycled regeneration reactions. In the presence of Thio-NAD, the enzyme 3-α hydroxysteroid dehydrogenase (3-α HSD) converts bile acids to 3-keto steroids and Thio-NADH (Fig. 1).  The reaction is reversible and 3-α HSD can convert 3-keto steroids and Thio-NADH to bile acids and Thio-NAD.  In the presence of excess NADH, the enzyme cycling occurs efficiently and the rate of formation of Thio-NADH is determined by measuring specific change of absorbance at 405nm 5.

Fig 1: Enzyme cycling assay principle 5
Fig 1: Enzyme cycling assay principle (5th Generation Bile Acids)

Want to know more?

Contact us or download the Total Bile Acids Whitepaper.

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Apolipoprotein A-I

Reagent | Apolipoprotein A-I

Key benefits of the Randox Apolipoprotein A-I reagent

Exceptional measuring range

The Randox albumin assay has a measuring range 5.27 – 251mg/dl for the comfortable detection of results.

Excellent stability

The Randox Apolipoprotein A-I reagent is stable to expiry when stored at 2-8°C

Applications available

Applications available detailing instrument-specific settings for a variety of clinical chemistry analysers.

Liquid ready-to-use reagents

 Liquid format which is more convenient, and can also help reduce the risk of errors occurring

Ordering information

Cat NoSize    
LP2116R1 4 x 40ml (C)
R2 4 x 17ml
EnquireKit Insert RequestMSDSBuy Online
LP3838R1 4 x 30ml
R2 4 x 12ml
EnquireKit Insert RequestMSDSBuy Online
LP8007R1 4 x 30ml
R2 4 x 12ml
EnquireKit Insert RequestMSDSBuy Online
(C) Indicates calibrator included in kit

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is Apolipoprotein A-I assay used for?

The Apolipoproteins are the main form of protein found in High Density Lipoproteins (HDL). The main role of APO A-I is in the activation of Lecithin Cholesterol Acyl Transferase (LCAT) and removal of free cholesterol from extra hepatic tissues. APO A-I may therefore be described as non atherogenic, showing an inverse relationship to cardiovascular risk.

APO A-I may be measured in patients with a personal or family history of high concentrations of lipids and/or premature CHD. It may be requested to find out the cause of high lipid levels and/or a suspected disorder that is causing a deficiency in APO A-I. APO A-I can be used with APO B-100 to check your ratio of “good” to “bad” cholesterol


Abbott Architect

Randox Acetaminophen Reagent

We develop a range of applications for the Abbott Architect analyser so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer, Randox Laboratories. We have 88 reagents available for the Abbott Architect, and are always developing more. If you don’t see the application you are looking for, please contact us to request an application.

All kits are produced to international standard and have ISO 13485 accreditation.

Existing customers can access IFU’s through Powerline.

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sTfR Assay

Reagent | Soluble Transferrin Receptor

Key benefits of the Randox sTfR assay

Excellent correlation
correlation coefficient of r=0.977 was displayed when the Randox methodology was compared against other commercially available methods.

Latex Enhanced Immunoturbidimetric method
Facilitating testing on biochemistry analysers and eliminating the need for dedicated equipment

Excellent measuring range
The healthy range for sTfR is 0.65 – 1.88mg/L. The Randox sTfR assay can comfortably detect levels outside of the healthy range, measuring between 0.5 – 11.77 mg/L.

Liquid ready-to-use assay
The Randox sTfR assay is available in a liquid ready-to-use format for convenience and ease-of-use.

Stable to expiry date
The Randox sTfR assay is stable to expiry date when stored at +2 to +8°C

Applications are available
Applications are available detailing instrument-specific settings for the convenient use of the Randox soluble transferrin receptor assay on a wide range of clinical chemistry analysers.

Ordering information

Cat NoSize    
TF10159R1 1 x 9ml
R2 1 x 5.8ml
EnquireKit Insert RequestMSDSBuy Online
  • Clinical Significance
  • Biological Significance
  • Completing your anaemia toolbox

The most common nutritional deficiency globally is iron deficiency (ID) with 15% to 20% of the global population affected by IDA 1. IDA has also been recognised as the most common form of anaemia in infants aged between 4 and 24 months of age, school-age children, female adolescents, pregnant women, and nurturing mothers. It has been recognised that young children including infants require high levels of iron during growth periods making them more susceptible to ID 2.

Soluble transferrin receptor levels have also been found to be a strong biomarker of erythropoietic and haemolysis drive compared to iron-restricted erythropoiesis in paediatric sickle cell disease 3.

Another study found that elevated levels of sTfR is linked with central obesity in men with hyperferritinemia 4.

sTfR has also “been included in multivariable blood testing models for the detection of performance enhancing erythropoietin misuse in sport” and has been recommended as a marker of ID in athletes 5.

A truncated extracellular form of the membrane transferrin receptor, soluble transferrin receptor (sTfR) is a marker of iron status and erythropoiesis. sTfR levels have been found to increase in iron-deficient erythropoiesis and iron deficiency anaemia (IDA). Some have reported that sTfR is useful in the differential diagnosis of IDA and anaemia of chronic disease or inflammation (ACD)1.

At present, ferritin remains the traditional iron deficiency marker with serum ferritin reflecting intracellular iron storage. Ferritin is an acute phase reactant, and so ferritin levels can be influenced by inflammatory conditions. In the presence of inflammation, ferritin levels may be represented as an elevated value leading to a false representation of iron stores in the body, resulting in a delayed diagnosis. For these reasons, sTfR should be tested when the reliability of a ferritin test is compromised.

There isn’t a single diagnostic test to diagnose anaemia. Currently the diagnosis comprises of two steps:

> Firstly confirming that the patient has anaemia which utilises the haemoglobin assay and red blood cell count.

> Secondly is the determination of the root cause of the anaemia which can be identified through testing sTfR and transferrin levels.

Randox offer a number of diagnostic reagents in addition to sTfR which can be used on a wide range of biochemistry analysers for the diagnosis of anaemia. The Randox assays have shown clinical utility in testing for anaemia. The Randox anaemia toolbox comprises of: iron, ferritin, transferrin, unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC) and the recent addition of sTfR.

There are many different types of anaemia and many triggers and conditions which contribute to the development of anaemia. For this reason, a single test cannot diagnose an individual with anaemia while also knowing what the root cause of it is. Additionally, patient symptoms can give an indication but a full range of diagnostic tests provide independent information to aid the definitive medical diagnosis and enable clinicians to provide effective treatment for patients.

 

Related products

sTfR Control

sTfR Calibrator

Resource Hub

  • References

    [1] Freixenet, N. et al., 2009. Serum soluble transferrin receptor concentrations are increased in central obesity. Results from a screening programme for hereditary hemochromatosis in men with hyperferritinemia. 400(1-2).

    [2] Lulla, R., Thompson, A. & Liem, R., 2010. Elevated soluble transferrin receptor levels reflect increased erythropoietic drive rather than iron deficiency in pediatric sickle cell disease.

    [3] Monajemzadeh, S. M. & Zarkesh, M. R., 2009. Iron deficieny anemia in infants aged 12-15 months in Ahwaz, Iran. 52(2).

    [4] Schumacher, Y., Schmid, A., König, D. & Berg, A., 2002. Effects of exercise on soluble transferrin receptor and other variables of the iron status.

    [5] Yoon, S. H. et al., 2015. The usefulness of soluble transferrin receptor in the diagnosis and treatment of iron deficiency anemia in children.


CK-NAC Reagent

Reagent | CK-NAC

Key Benefits of the Randox CK-NAC reagent

Exceptional correlation with standard methods

The Randox methodology was compared against other commercially available methods and the Randox CK-NAC assay showed a correlation coefficient of r=0.99

Wide measuring range

The Randox CK-NAC reagent can comfortably detect levels outside of the healthy range measuring between 9.16 – 2886 U/l.

Excellent stability

Stable until expiry date when stored at +2 to +8°C

Other features of the Randox CK-NAC reagent

  • UV DGKC method
  • Available as liquid and lyophilised reagents
  • Stable until expiry date when stored at +2 to +8°C
  • Measuring range 9.16 – 2886 U/l

Ordering information

Cat NoSize    
CK11020 x 2.5mlEnquireKit Insert RequestMSDSBuy Online
CK3812R1 4 x 20ml
R2 4 x 6ml
EnquireKit Insert RequestMSDSBuy Online
CK3892R1 4 x 16.5ml (L)
R2 4 x 6.2ml (IFCC)
EnquireKit Insert RequestMSDSBuy Online
CK8313R1 4 x 20ml (L)
R2 4 x 7ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the CK-NAC assay used for?

What is CK-NAC?

The small amount of Creatine Kinase (CK) present in the blood primarily comes from skeletal muscle. CK is also found in striated muscle, brain and heart tissues. The CK concentration levels in the blood increase as a result of damage to bodily muscle or interferences with the muscle energy production such as myositis, which is inflammation of the muscles.

What is the CK-NAC assay used for?

The Randox CK-NAC reagent is used for the measurement of CK in serum or plasma to assess the extent of muscle damage and to monitor treatment.

The determination of CK-NAC activity in plasma or serum provides a sensitive marker for the detection of skeletal muscle disease; and is also useful to assess the extent of severe muscle trauma, crush injuries, burns or electrocution, and the likelihood of developing rhabdomyolysis.   For more information on the spectrum of rhabdomyolysis, please click here [external link].

The determination of CK using creatine phosphate and adenosine‑5’‑diphosphate (ADP) as substrates rather than creatine and adenosine‑5’‑triphosphate (ATP) has several advantages in test performance as it allows for a faster reaction rate resulting in greater sensitivity. Small sample volumes are used and sample blanks are not required.

The UV method used is an optimised standard method according to the recommendations of the Deutsche Gesellschaft für Klinische Chemie.

Clinical Chemistry Panel

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Veterinary Panel

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CK-MB Reagent

Reagent | CK-MB

Key Benefits of the Randox CK-MB reagent

Liquid and lyophilised reagents available

The Randox CK-MB reagent is available in a liquid ready-to-use or in a lyophilized format offering you convenience and choice when selecting the best choice for your laboratory

Wide measuring range

The Randox CK-MB reagent can comfortably detect levels outside of the healthy range measuring between 9.1 – 2216 U/l.

Excellent stability

Stable until expiry date when stored at +2 to +8°C

Other features of the Randox CK-MB reagent

  • Immunoinhibition UV method
  • Available as liquid and lyophilised reagents Stable until expiry date when stored at +2 to +8°C
  • Stable until expiry date when stored at +2 to +8°C
  • Measuring range 9.1 – 2216 U/l
Cat NoSize    
CK129619 x 2.5mlEnquireKit Insert RequestMSDSBuy Online
CK3813R1 4 x 20ml
R2 4 x 6ml
EnquireKit Insert RequestMSDSBuy Online
CK4043R1 4 x 20ml
R2 4 x 6ml (L)
EnquireKit Insert RequestMSDSBuy Online
CK8148R1 4 x 20ml (L)
R2 4 x 8ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid option

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the CK-MB assay used for?

What is CK-MB?

Creatine Kinase (CK) is internationally accepted as a sensitive and specific indicator of acute myocardial infarction (AMI). There are 3 major forms of the iso-enzymes of CK, CK-MM, CK-MB and CK-BB. CK-BB is produced by the brain in very small insignificant amounts. CK-MM is produced by the skeletal and heart tissue. CK-MB is produced by the heart muscle and increases when the heart muscle is damaged. For more information on the structure and function of CK isoenzymes in tissue, please click here.

What is the CK-MB assay used for?

CK-MB is a more sensitive marker to myocardial infarction than total CK activity as CK-MB has a lower basal level and a narrower normal range.  In the vast majority of cases the CK-MB activity rises within 4 to 6 hours of an acute infarction.  Between 10 to 24 hours, maximum values are observed. The CK-MB activity generally returns to normal between the third and fourth day post- infarction.

The Randox CK-MB reagent can measure small, but significant changes in CK-MB activity during the early hours following the onset of chest pain.

Clinical Chemistry Panel

For more information or to view more reagents within the clinical chemistry panel, please click here

Cardiology Panel

For more information or to view more reagents within the cardiology panel, please click here


Featured Reagent – D-3-Hydroxybutyrate (Ranbut)

Featured Reagent | D-3-Hydroxybutyrate

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Benefits of D-3-Hydroxybutyrate

Superior Methodology – The commercially available nitroprusside method is a semi-quantitative dipstick test which only detects acetone and acetoacetate. As the most abundant ketone produced during ketosis, D-3-hydroxybutyrate is more sensitive and specific.

Excellent precision – The Randox Ranbut assay displayed an excellent precision of <3.5%.

Exceptional correlation – A correlation coefficient of r=0.9954 was displayed when the Randox method was compared against other commercially available methods.

Wide Measuring Range – The Randox Ranbut assay has a measuring range of 0.100 – 5.75mmol/l for the comfortable detection of clinically important results.

Calibrator and controls available – Randox offer a complete testing package.

Applications available – Detail of instrument-specific settings for the convenient use of the Randox Ranbut assay on a variety of clinical chemistry analysers.

Traditional Methods

Ketogenesis is a biochemical process whereby the body produces ketone bodies (acetone, acetoacetate, beta-hydroxybutyrate). As ketone bodies are water soluble, they do not require lipoproteins for transport 1.

In healthy humans, small amounts of ketones are continuously made for the body to use an energy source. Ketone bodies increase in times of fasting and sleeping 1.

Physiological Significance

Urinalysis is an essential part of the diagnostic review for kidney disease and other renal impairments. Whilst the dipstick test allows for rapid and simultaneous chemical analyses of urine, including ketones, the chemical reactions on dipsticks are complicated and can be affected by oxidising, reducing, and discolouring substances in urine. Therefore, false positives and false negative results are common in dipstick testing 4.

Clinical Significance

When the carbohydrate stores are significantly decreased, or the fatty acid concentration is increased, there is an upregulation of the ketogenic pathway and consequently, an increased production of ketone bodies. This is commonly observed in alcoholism, type I diabetes and starvation. Most organs, including the brain, can utilise ketones whereas the heart utilises fatty acids as its source of energy, but can also use ketones. The liver however, cannot utilise ketones, despite producing them as the liver lacks the necessary enzyme ketoacyl-CoA transferase 1.

Ketosis is the presence of ketones. Whilst ketosis is not dangerous, if left untreated, especially in diabetes, ketoacidosis (high levels of ketones) develops 2.

In type 1 diabetes mellitus (T1DM), the body is unable to produce insulin resulting in bodily cells not receiving energy from glucose, causing the body to release hormones to breakdown fat for energy, producing ketones. If left untreated, diabetic ketoacidosis develops, a serious health condition. Diabetic ketoacidosis is commonly triggered by an illness, infection or missing insulin treatments 3.

Did you know?

Ketone bodies increase in times of fasting and sleeping 1 and is considered harmless, however, if left untreated, especially in diabetes, ketoacidosis occurs 2.

References

[1] Dhillon KK, Gupta S. Biochemistry, Ketogenesis. Treasure Island: StatPearls Publishing; 2020. https://www.ncbi.nlm.nih.gov/books/NBK493179/ (accessed 28 September 2020).

[2] Hecht M. Ketosis vs. Ketoacidosis: What You Should Know. https://www.healthline.com/health/ketosis-vs-ketoacidosis (accessed 28 September 2020).

[3] Mayo Clinic. Diabetic ketoacidosis. https://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/symptoms-causes/syc-20371551 (accessed 28 September 2020).

[4] Han TH. Urinalysis: The Usefulness and Limitations of Urine Dipstick Testing. Journal of the Korean Society if Pediatric Nephrology 2013; 17(2): 42-48.

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Cholinesterase (Butyryl) (BCHE / BuCHE) Reagent

Reagent | Cholinesterase (Butyryl) (BCHE / BuCHE)

Key Benefits of the Cholinesterase (Butyryl) (BCHE / BuCHE) reagent

Exceptional correlation with standard methods

The Randox methodology was compared against other commercially available methods and the Randox cholinesterase (butyryl) reagent showed a correlation coefficient of r=0.9959

Wide measuring range

The healthy range for cholinesterase (butyryl) is 3700 – 13200 U/l. The Randox cholinesterase (butyryl) reagent can comfortably detect levels outside of the healthy ranges measuring between 455 – 28722 U/l.

Excellent stability

Stable for 6 weeks when stored at +2 to +8°C

Other features of the Cholinesterase (Butyryl) (BCHE / BuCHE) reagent

  • Colorimetric method
  • Lyophilised reagents
  • Correlation coefficient of r=0.99 when compared with another commercially available method
  • Stable for 6 weeks when stored at +2 to +8°C
  • Wide measuring range 455 – 28722 U/l

Ordering information

Cat NoSize    
CE190R1 5 x 30ml
R2 5 x 1ml
EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the Cholinesterase (Butyryl) (BCHE / BuCHE) assay used for?

What is cholinesterase (butyryl)?

Cholinesterase (butyryl) (BCHE / BuCHE), also known as pseudocholinesterase, is a protein coding gene and is a serine hydrolase synthesised in the liver and is responsible for catalysing the hydrolysis of numerous choline esters.  It can be found in the liver, intestinal mucosa, plasma, pancreas and the white matter of the central nervous system of mammals.

The Randox Cholinesterase (butyryl) reagent is used for the quantitative in vitro determination of BCHE in serum and plasma. BCHE can be used to diagnose cholinesterase (butyryl) deficiency and curariform drugs toxicity.

The Randox Cholinesterase (butyryl) reagent can also be used as a diagnostic and therapeutic marker for Alzheimer’s disease as BCHE activity progressively increases in patients with Alzheimer’s disease whereas acetylcholinesterase activity remains the same or declines. In Alzheimer’s disease, BCHE is found in association with beta-amyloid plaques and the cerebral cortex, whereas it is not commonly found in any other case. A study carried out by NCBI found that when the BCHE gene is not found in the brain, there are up to 70% less beta-amyloid plaques. For more information on the diagnosis of Alzheimer’s disease, please click here [external link].

Clinical Chemistry Panel

For more information or to view more reagents within the clinical chemistry panel, please click here

Veterinary Panel

For more information or to view more reagents within the veterinary panel, please click here


sdLDL Cholesterol Assay

Reagent | Small Dense LDL Cholesterol (sdLDL-C)

Size Matters: The True Weight of Risk in Lipid Profiling

Benefits of the Randox sdLDL-C Assay

Superior Performance

Superior method

The clearance method produces results in as little as ten minutes, facilitating faster patient diagnosis and treatment plan implementation. The previous methods, ultracentrifugation and electrophoresis, were laborious and time consuming.

Exceptional correlation

correlation coefficient of r=0.99 was displayed when the Randox methodology was compared against the gold standard method, ultracentrifugation.

Wide measuring range

The Randox sdLDL-C assay has a measuring range of 4 – 100mg/dl for the comfortable detection of clinically important results.

Liquid ready-to-use assay

The Randox sdLDL-C assay is available in a liquid ready-to-use format for convenience and ease-of-use.

Calibrator & Controls

Dedicated calibrator and control available

Dedicated sdLDL-C calibrator and control available offering a complete testing package.

Applications available

Applications are available detailing instrument-specific settings for the convenient use of the Randox sdLDL-C assay on a wide range of clinical chemistry analysers.

  • Ordering Information
  • Physiological Significance
  • Risk Assessment
  • Management
  • Methods of Detection
Cat NoSize    
562616R1 1 x 19.8ml
R2 1 x 8.6ml
EnquireKit Insert RequestMSDSBuy Online
CH8153R1 1 x 16.2ml
R2 1 x 8.2ml
EnquireKit Insert RequestMSDSBuy Online
562760 (U)R1 1 x 18ml
R2 1 x 7ml
EnquireKit Insert RequestMSDSBuy Online
562791 *(U)R1 5 x 200mlEnquireKit Insert RequestMSDSBuy Online
562807 *(U)R2 2 x 200mlEnquireKit Insert RequestMSDSBuy Online
(U) Indicates for use in the USA only
(*) Indicates that boths kits must be purchased together

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

When measuring LDL cholesterol (LDL-C), it is the cholesterol mass within the LDL particles that is being measured. The LDL particle population within LDL is heterogeneous – meaning that the size, density & composition of each particle will be different. sdLDL-C is a subfraction of low density lipoprotein (LDL) with smaller particle size and higher density than larger more buoyant LDL. They all transport triglycerides and cholesterol to the tissues, but their atherogenesis varies according to their size. sdLDL-C will more readily permeate the inner arterial wall. sdLDL-C is more susceptible to oxidation and has a lower affinity to the hepatic LDL receptor, and as such circulates in the blood longer1.

As sdLDL-C is particularly atherogenic, a person with elevated sdLDL-C levels has a 3-fold increased risk of myocardial infarction (MI)2.
sdLDL-C measurement therefore provides a more comprehensive understanding of cardiovascular disease (CVD) risk compared to traditional LDL-C tests.

sdLDL-C Scale

Reducing sdLDL-C levels will aid in reducing the risk of CVD and MI. High dose statin therapy has been proven to aid in reducing the levels of sdLDL-C as a risk factor for cardiovascular events and high risk patients. Elevated levels of sdLDL-C arise from multiple sources. A major factor is a sedentary lifestyle with a diet high in saturated fat. Insulin resistance and pre-diabetes have also been implicated, in addition to genetic predisposition3.

The measurement of LDL-C or the review of levels within arteriosclerotic coronary heart disease (ASCHD) treatment are known within different guidelines (including ATP III, AHA/ ACC, ESC/ EAS and NICE). However doubt remains on the impact of targeting LDL-C only. The inclusion of sdLDL-C within the clinical testing panel will assist in removing this doubt.

The only direct automated sdLDL-C kit on the market, the Randox sdLDL-C test is a direct method for the quantitative determination of sdLDL-C using automated chemistry analysers capable of accommodating two-reagent assays. The assay consists of two steps and is based on the use of well-characterised surfactants and enzymes that selectively react with certain groups of lipoproteins.

sdLDL-C Calibrator

sdLDL-C Control

Lipid EQA Scheme


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