Lipoprotein(a) Assay

Home - Reagents - Page 4

Lipoprotein(a) Assay

Reagent | Lipoprotein(a) Assay

Traceable to the WHO/IFCC Reference Material

Benefits of the Randox Lp(a) Assay

WHO/IFCC reference material

The Randox Lp(a) assay is calibrated in nmol/l and traceable to the WHO/IFCC reference material (IFCC SRM 2B) and provides an acceptable bias compared with the Northwest Lipid Metabolism Diabetes Research Laboratory (NLMDRKL) gold standard method.

Dedicated five-point calibrator available

Five-point calibrator with accuracy-based assigned target values (in nmol/l) is available, accurately reflecting the heterogeneity of the apo(a) isoforms. Dedicated Lp(a) control is available offering a complete testing package.

Excellent correlation

correlation coefficient of r=0.995 was displayed when the Randox method was compared against other commercially available methods.

Precision

Excellent precision

The Randox Lp(a) assay displayed a within run precision of <2.54%.

Liquid ready-to-use

The Randox Lp(a) assay is available in a liquid ready-to-use format for convenience and ease-of-use.

Applications available

Applications are available detailing instrument-specific settings for the convenient use of the Randox Lp(a) assay on a wide range of clinical chemistry analysers.

Ordering information

Cat NoSize    
LP2757R1 1 x 30ml
R2 1 x 15ml
EnquireKit Insert RequestMSDSBuy Online
LP3403R1 1 x 10ml
R2 1 x 6ml
EnquireKit Insert RequestMSDSBuy Online
LP8054R1 2 x 8.7ml
R2 2 x 5.8ml
EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

  • Challenges
  • Clinical Significance
  • Frequency of Testing
  • WHO/IFCC
  • HEART UK
  • COVID-19

The biggest challenge that exists surrounding Lp(a) measurement is the heterogeneity of the apo(a) isoforms, resulting in the underestimation or overestimation of Lp(a) concentrations. In immunoassays, the variable numbers of repeated KIV-2 units in Lp(a) act as multiple epitopes. This is where standardisation across calibrators is vital. Unless the calibrants do have the same range of isoforms as test samples, those with higher numbers of the KIV-2 repeat, will represent with an overestimation in Lp(a) concentrations and those with smaller numbers of the KIV-2 repeat, will represent with an underestimation. The smaller isoforms are strongly associated with higher Lp(a) concentrations. Lack of standardisation of the calibrant would result in an underestimation of Lp(a) associated CVD risk. It is important to note that an Lp(a) immunoassay employing isoform insensitive antibodies does not exist 1.

The gold standard Lp(a) method is the Northwest Lipid Metabolism and Diabetes Research Laboratory (NLMDRKL) method which employs an isoform insensitive antibody and is meticulously calibrated with well characterised material; however, this test is not commercially available 1.

Lp(a) assays that are standardised to the WHO/IFCC reference material, transferring values from mg/dl to nmol/l are more uniformed. The Denka Seiken Lp(a) assay is the most reliable commercially available Lp(a) assay, because 1:

1. The isoform size variations are reduced as a range of calibrators from separate pools of serum were used which covered a range of Lp(a) concentrations.

2. The isoform size and concentrations are inversely correlated better matching calibrants with test samples.

3. Methods based on the Denka Lp(a) assay, calibrated in nmol/l and traceable to WHO/IFCC reference material gave acceptable bias compared with the NLMDRL gold standard method.

Lp(a) measurement could be of value in those with a family history of premature CVD (<60 years), especially when a causative mutation for familial hypercholesterolemia (FH) hasn’t been identified. In patients with heterozygous FH (HeFH), Lp(a) levels are higher compared to their non-affected siblings. Lp(a) has been identified as a strong risk factor of coronary heart disease (CHD) in patients with HeFH, independent of age, sex, smoking status, and LDL-C levels 1.

Understanding a FH patients Lp(a) levels can aid the physician in identifying the patient’s risk of a cardiovascular event and in the evaluation of treatment methods. However, Lp(a) is not a predictor of CHD in HeFH patients on currently available cholesterol-lowering treatment but may be when lower LDL-C levels are achieved. On this basis, it is recommended that Lp(a) levels are measured in all genetic dyslipidaemias 1.

Lp(a) has been identified as a potent risk factor for calcific aortic valve stenosis. Understanding a patients Lp(a) levels could aid in informing the selection of the interval for valve surveillance as patients with elevated Lp(a) levels are likely to require earlier intervention 1.

Lp(a) measurements aids in the re-classifying of those deemed at an intermediate CVD risk. Patients who over 10 years have >15% risk of a CV event should be receiving treatment, such as statin therapy irrespective of Lp(a) levels. The uptake of statin therapy in the UK as a primary prevention method for those deemed at an intermediate risk of CVD is poor 1. In the ‘Statin initiations and QRISK2 scoring in UK general practice: a THIN database study’ concluded that most patients deemed at a high risk of CVD were not initiated on statin therapy 2. Only 14% of patients with a 10-year CVD risk (10 – 19.9% risk) were initiated on statin therapy with one in six statin initiations were to low-risk patients 1, 2.

Lp(a) is believed to remain relatively stable over a lifespan as Lp(a) is predominantly genetically determined. Lp(a) testing is believed to more cost effective in comparison to genetic testing at this time. A single Lp(a) test is believed to be enough to improve the accuracy of cardiovascular risk assessment, however, qualification levels that are close to the action thresholds should be considered on a case-by-case basis. Repeat testing can be initiated if a secondary cause is suspected or therapeutic measures to lower Lp(a) levels have been instigated 1. The once-only recommendation for Lp(a) testing is consistent with the recently published European Guidelines 3, however HEART UK 1, recommend that Lp(a) are measured in specific cohorts as opposed to all adults. Currently, Lp(a) screening is not currently advocated by the HEART UK consensus panel. The European guideline aims to identify those at a very high risk (Lp(a) levels >430nmol/l), however, HEART UK argues that the risk conferred by Lp(a) occurs at a much lower threshold. Consequently, the HEART UK approach is to measure Lp(a) in specific populations and manage Lp(a) associated risk in those with levels >90nmol/l 1.

The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), through its Working Group on Lp(a) and together with research institutions and several diagnostic companies recommends that laboratories use assays which do not suffer from apo(a) size-related bias. The IFCC SRM 2B was accepted by the WHO Expert Committee on Biological Standardisation as the First WHO/IFCC International Reference Reagent for Lp(a) to ensure conformity by diagnostic companies to the European Union’s Directive on In vitro Diagnostic Medical Devices for the metrological traceability of calibrator materials 4.

Lp(a) has been identified to play a role in COVID-19. Those with either baseline elevated Lp(a) or those whose Lp(a) levels increased following infection from COVID-19, or both, may be at a significantly increased risk of developing thromboses. Elevate Lp(a) levels may cause acute destabilisation of pre-existing but quiescent, atherosclerotic plaques, which could induce an acute myocardial infarction and stroke 5.

Related products

Lp(a) Calibrator

Lp(a) Control

Lipid EQA Scheme

Reagents Resource Hub


Full Range CRP

Reagent | CRP Full Range

Key Benefits

Limited Interference

From Conjugate and Free Bilirubin, Haemoglobin, Intralipid and Triglycerides

Wide measuring range

The Randox Full Range CRP assay has a wide measuring range of 0.3 – 161 mg/l which will comfortably detect levels outside of the healthy range

Excellent stability

Stable to expiry when stored at 2-8⁰C

Methodology

Latex enhanced Immunoturbidimetric method

Ordering Information

Cat NoSize    
CP3847R1 2 x 11ml
R2 2 x 11ml
EnquireKit Insert RequestMSDSBuy Online
CP3849R1 4 x 50ml
R2 4 x 50ml
EnquireKit Insert RequestMSDSBuy Online
CP8028R1 2 x 13ml
R2 2 x 13ml
EnquireKit Insert RequestMSDSBuy Online
CP8315R1 4 x 10ml
R2 4 x 10ml
EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the Full Range CRP assay used for?

The extended reporting capability of the Randox Full Range CRP assay enables labs to improve efficiency, save time and costs by using a single method for both low and elevated CRP concentrations. Full Range CRP is particularly useful for the early detection of bacterial infections in new-born babies, where initial values are very low and can rise rapidly with the onset of infection.

A complete clinical history is required for accurate interpretation of CRP levels. CRP levels within the normal range may be affected by a number of different factors and should always be compared to previous values.


Featured Reagent – Lp(a)

Featured Reagent | Lipoprotein(a)

Back to Reagents Resource Hub >

 

Current Challenges

The biggest challenge that exists surrounding Lp(a) measurement is the heterogeneity of the apo(a) isoforms, resulting in the underestimation or overestimation of Lp(a) concentrations. In immunoassays, the variable numbers of repeated KIV-2 units in Lp(a) act as multiple epitopes. This is where standardisation across calibrators is vital. If the calibrants do have the same range of isoforms as test samples, those with higher numbers of the KIV-2 repeat, will represent with an overestimation in Lp(a) concentrations and those with smaller numbers of the KIV-2 repeat, will represent with an underestimation. The smaller isoforms are strongly associated with higher Lp(a) concentrations. Lack of standardisation of the calibrant would result in an underestimation of Lp(a) associated CVD risk. It is important to note that an Lp(a) immunoassay employing isoform insensitive antibodies does not exist 6.

Physiological Significance

Lipoprotein (a) [Lp(a)] is described as “the most complex and polymorphic of the lipoprotein particles”. Composed of a low-density lipoprotein (LDL) particle, an apolipoprotein(a) [apo(a)] particle which is covalently bonded to the apoB-100 via a disulphide bridge 1. Lp(a) is believed to have a chemical weight between 1.05 to 1.21 g/ml 2. Lp(a) behaves very differently to other apoB particles; LDL-C / sdLDL-C 3.

Apo(a) is the main component that distinguishes LDL from Lp(a) (Fig 2). Apo(a) is a large glycoprotein belonging to the plasminogen gene superfamily 1, 2. Comprised of five cysteine-rich domains called kringles, which are encoded by the LPA gene, located on the long (q) arm of chromosome 6 at positions 26 and 27 (6q26-27), and the plasminogen (PLG) gene, also located on the long (q) arm of chromosome 6 at position 26 (6q26) 2, 4, 5.

The PLG gene is believed to encode 5 kringles (types 1 to V) as well as an active protease domain. Conversely, kringles IV and V and an inactive protease domain are present in apo(a) 2. Apo(a) is described as polymorphic as the kringle type IV undergoes duplication, coding for 10 kringle IV types (K1 through K10).

The gold standard Lp(a) method is the Northwest Lipid Metabolism and Diabetes Research Laboratory (NLMDRKL) method which employs an isoform insensitive antibody and is meticulously calibrated with well characterised material, however, this test is not commercially available 6.

All kringles, except for K2, are present as single copies. K2 is present in multiple copies, ranging from 2 to >40, within the apo(a) proteins of distinct sizes (Fig 2). The number of K2 repeats determines the size of the apo(a) isoform, thus heterogeneously affecting the size of the apo(a) protein and the plasma levels of Lp(a). An inverse correlation between the size of the apo(a) isoform and plasma concentrations of Lp(a) has been identified 2.

Did you know?

Lp(a) should be measured utilising a method where the effect of the apo(a) isoform size has been minimised using calibrators that are certified against the WHO/IFCC reference material 5.

Benefits of Lp(a)

WHO/IFCC reference material – The Randox Lp(a) assay is calibrated in nmol/l and traceable to the WHO/IFCC reference material (IFCC SRM 2B) and provides an acceptable bias compared with the Northwest Lipid Metabolism Diabetes Research Laboratory (NLMDRKL) gold standard method.

Dedicated calibrator & control available – Five point calibrator with accuracy-based assigned target values (in nmol/l) is available, accurately reflecting the heterogeneity of the apo(a) isoforms. Dedicated Lp(a) control is available offering a complete testing package.

Excellent correlation – A correlation coefficient of r=0.995 was displayed when the Randox method was compared against other commercially available methods.

Precision Excellent precision – The Randox Lp(a) assay displayed a within run precision of <2.54%.

Liquid ready-to-use – The Randox Lp(a) assay is available in a liquid ready-to-use format for convenience and ease-of-use.

Applications available – Instrument-specific settings can be provided for a wide range of clinical chemistry analysers.

Clinical Significance

Lp(a) has been identified as a potent risk factor for calcific aortic valve stenosis. Understanding a patients Lp(a) levels could aid in informing the selection of the interval for valve surveillance as patients with elevated Lp(a) levels are likely to require earlier intervention 6.

Lp(a) measurement could be of value in those with a family history of premature CVD (<60 years), especially when a causative mutation for familial hypercholesterolemia (FH) hasn’t been identified.

In patients with heterozygous FH (HeFH), Lp(a) levels are higher compared to their non-affected siblings. Lp(a) has been identified as a strong risk factor of coronary heart disease (CHD) in patients with HeFH, independent of age, sex, smoking status, and LDL-C levels 6.

Lp(a) measurements aids in the re-classifying of those deemed at an intermediate CVD risk. Patients who over 10 years have >15% risk of a CV event should be receiving treatment, such as statin therapy irrespective of Lp(a) levels. The uptake of statin therapy in the UK as a primary prevention method for those deemed at an intermediate risk of CVD is poor 5. In the ‘Statin initiations and QRISK2 scoring in UK general practice: a THIN database study’ concluded that most patients deemed at a high risk of CVD were not initiated on statin therapy 7. Only 14% of patients with a 10-year CVD risk (10 – 19.9% risk) were initiated on statin therapy with one in six statin initiations were to low-risk patients 6, 8.

Fig 3: Lp(a) Infographic 7

  • WHO/IFCC Reference Material
  • HEART UK

The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), through its Working Group on Lp(a) and together with research institutions and several diagnostic companies recommends that laboratories use assays which do not suffer from apo(a) size-related bias. The IFCC SRM 2B was accepted by the WHO Expert Committee on Biological Standardisation as the First WHO/IFCC International Reference Reagent for Lp(a) to ensure conformity by diagnostic companies to the European Union’s Directive on In vitro Diagnostic Medical Devices for the metrological traceability of calibrator materials 9.

References

[1] Marcovina SM, Albers JJ. Lipoprotein (a) measurements for clinical application. Journal of Lipid Research 2019; 57(): 526-537.

[2] Nordestgaard BG, Chapman MJ, Ginsberg HN. Lipoprotein (a): EAS Recommendations for Screening, Desirable Levels and Management, 1st ed. Dorset: Sherborne Gibbs Limited; 2012.

[3] AMGEN Science. 10 Things to Know About Lipoprotein(a). https://www.amgenscience.com/features/10-things-to-know-about-lipoproteina/ (accessed 17 December 2019).

[4] Bermudez V, Rojas J, Salazar J, Bello L, Anez R, et al. Variations of Lipoprotein(a) Levels in the Metabolic Syndrome: A Report from the Maracaibo City Metabolic Syndrome Prevalence Study. Journal of Diabetes Research 2013; 2013(416451): 1-12. https://www.hindawi.com/journals/jdr/2013/416451/ (accessed 29 November 2019).

[5] Genetics Home Referencing. PLG gene. https://ghr.nlm.nih.gov/gene/PLG (accessed 29 November 2019).

[6] Cegla J, Dermot R, Neely G, France M, Ferns G, et al. HEART UK consensus statement on Lipoprotein(a): A call to action. Atherosclerosis 2019; 291(): 62-70.

[7] McGill University Health Centre. What is high lipoprotein(a), and should I be concerned?. https://medicalxpress.com/news/2017-02-high-lipoproteina.html (accessed 17 December 2019)

[8] Finnikin S, Ryan R, Marshall T. Statin initiations and QRISK2 scoring in UK general practice: a THIN database study. British Journal of General Practice 2017; 67(665): 881-887. https://bjgp.org/content/67/665/e881.long (accessed 3 December 2019).

[9] Dati F, Tate JR, Marcovina SM, Steinmetz A, et al. First WHO/IFCC International Reference Reagent for Lipoprotein(a) for Immunoassay–Lp(a) SRM 2B. Clinical Chemistry and Laboratory Medicine 2004; 42(6): 670-676.

Featured Reagents Homepage

For more Featured Reagents click VISIT


Other Instruments

Randox Acetaminophen Reagent

Applications available for third-party analysers

Randox develop a range of applications for a wide range of third-party analysers, including the ones listed below, so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer. For more information on the analysers below or any others that you don’t see listed, please email us.

Beckman Synchron CX4 / 5 / 7 / 9 / LX20 / DxC

Biolis 24i / Prestige 24i

Ortho Vistros 5600 / 5 / i FS / 4600

Pentra 400

Siemens Dimension RXL / Xpand

Vitalab Flexor / Selectra E / Selectra II

Email Us

Get in touch with Randox via email at reagents@randox.com

Need Instructions?

Download a kit insert for free on our online portal

Buy Online

Order your lipid kits today by visiting our online store 


Siemens Atellica

Randox Acetaminophen Reagent

Applications for Siemens Atellica

We develop a range of applications for the Siemens Atellica analyser so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer, Randox Laboratories.

Randox Applications for Siemens Atellica

We have 31 reagents available for the Siemens Atellica, and are always developing more. If you don’t see the application you are looking for, please email us to request an application. All kits are produced to international standard and have ISO 13485 accreditation.

Aldoase
Apolipoprotein A-II
Apolipoprotein C-II
Apolipoprotein C-III
Apolipoprotein E
Bile Acids
Cholesterol sdLDL
CK-MB
Creatinine
CRP Canine
D-3-Hydroxybutyrate (Ranbut)

Ferritin
G6PDH
GLDH
Glucose
Glutamate
Glutamine
Glutathione Peroxidase (Ransel)
Glutathione Reductase
Glycerol
Haemoglobin
Homocysteine

IgE
Lactate Dehydrogenase (P-L)
Myoglobin
NEFA
Superoxide Dismutase (Ransod)
Syphilis
Total Antioxidant Status (TAS)
Urinary Protein
Zinc

Email Us

Get in touch with Randox via email at reagents@randox.com

Need Instructions?

Download a kit Inserts free on our online portal

Buy Online

Order your reagents kits online by visiting our online store 


Mindray BS

Randox Acetaminophen Reagent

Applications for Mindray BS Series

We develop a range of applications for the Mindray BS Series (120 / 200 / 300 / 400) analysers so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer, Randox Laboratories.

Applications for Mindray BS Series

We have 74 reagents available for the Mindray BS Series (120 / 200 / 300 / 400), and are always developing more. If you don’t see the application you are looking for, please email us to request an application. All kits are produced to international standard and have ISO 13485 accreditation.

Albumin
Aldolase
Alkaline Phosphatase
ALT
Ammonia
Amylase
Apolipoprotein A-I
Apolipoprotein B
ASO
AST
ß2 Microglobulin
Bile Acids
Bilirubin
Calcium
Cholesterol Total
Cholesterol HDL
Cholesterol LDL
Cholesterol sdLDL
Cholinesterase (Butyryl)
CK-MB
CK-NAC
CO2
Total
Complement C3
Complement C4
Copper
Creatinine

CRP
CRP Canine
Cystatin C
D-3 Hydroxybutyrate (Ranbut)
Ethanol
Ferritin
Fructosamine
G6PDH
Gamma GT
GLDH
Glucose
Glutathione Peroxidase (Ransel)
Glutathione Reductase
Haptoglobin
HbA1c
Homocysteine
IgA
IgE
IgG
IgM
Iron
L-Lactate
LD Lactate – Pyruvate
LD Pyruvate – Lactate
Lipase
Lipoprotein (a)
Malic Acid

Magnesium
Microalbumin
NEFA
Phosphorus
Potassium
Primary Amino Nitrogen
Rheumatoid Factor (RF)
Sodium
Superoxide Dismutase (Ransod)
Total Antioxidant Status (TAS)
Total Iron Binding
Capacity (TIBC)
Total Protein
Transferrin
Transthyretin (Prealbumin)
Triglycerides
Urea
Uric Acid
Urinary Protein
Zinc

Email Us

Get in touch with Randox via email at reagents@randox.com

Need Instructions?

Download your kit insert for free on our online portal

Buy Online

Order your reagents kits online by visiting our online store 


Thermo Konelab

Randox Acetaminophen Reagent

Applications for Thermo Konelab

We develop a range of applications for the Thermo Konelab (20i / 30i / 60i) analysers so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer, Randox Laboratories.

Randox applications available for Thermo Konelab

We have 86 reagents available for the Thermo Konelab (20i / 30i / 60i), and are always developing more. If you don’t see the application you are looking for, please email us to request an application. All kits are produced to international standard and have ISO 13485 accreditation.

Albumin
Aldolase
Alkaline Phosphatase
ALT
Ammonia
Amylase
Apolipoprotein A-I
Apolipoprotein A-II
Apolipoprotein B
Apolipoprotein C-II
Apolipoprotein C-III
Apolipoprotein E
ASO
AST
ß2 Microglobulin
Bile Acids
Bilirubin
Calcium
Carbamazepine
Cholesterol Total
Cholesterol HDL
Cholesterol LDL
Cholesterol sdLDL
Cholinesterase (Butyryl)
CK-MB
CK-NAC
CO2 Total
Complement C3
Complement C4

Copper
Creatinine
CRP
CRP Canine
CRP Full Range
CRP High Sensitivity
Cystatin C
D-3 Hydroxybutyrate (Ranbut)
Digoxin
Ethanol
Fructosamine (Glycated Protein)
G6PDH
Gamma GT
GLDH
Glucose
Glutamate
Glutathione Peroxidase (Ransel)
Glutathione Reductase
Glycerol
HbA1c
Homocysteine
IgA
IgE
IgG
IgM
Iron
L-Lactate
LD Pyruvate – Lactate
LD Lactate – Pyruvate

Lipase
Lipoprotein (a)
Magnesium
Microalbumin
Myoglobin
NEFA
Phenobarbital
Phenytoin
Phosphorus
Potassium
Rheumatoid Factor (RF)
Sodium
Superoxide Dismutase (Ransod)
Total Antioxidant Status
Total Iron Binding
Capacity (TIBC)
Total Protein
Transferrin
Transthyretin (Prealbumin)
Triglycerides
Urea
Uric Acid
Urinary Protein
Valproic Acid
Zinc

Email Us

Get in touch with Randox via email at reagents@randox.com

Need Instructions?

Download a kit Inserts free on our online portal

Buy Online

Order your reagents kits online by visiting our online store 


Siemens Dimension RxL/ Xpand

Randox Acetaminophen Reagent

Applications for Siemens Dimension RxL/Xpand

We develop a range of applications for the Siemens Dimension RxL/ Xpand analysers so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer, Randox Laboratories.

We have 31 reagents available for the Siemens Dimension RxL/ Xpand, and are always developing more. If you don’t see the application you are looking for, please contact us to request an application. All kits are produced to international standard and have ISO 13485 accreditation.

Randox applications available

Albumin
Aldolase
ALT
Amylase
Apolipoprotein A-I
Apolipoprotein B
ASO
Bile Acids
Ceruplasmin
Cholesterol sdLDL
CK-MB
Complement C3
Complement C4
Creatinine

CRP
CRP Canine
D-3 Hydroxybutyrate (Ranbut)
Fructosamine (Glycated Protein)
G6PDH
GLDH
Glucose
Glutathione Reductase
Glycerol
Haptoglobin
Iron
L-Lactate
LD
Lipase

Lipoprotein (a)
Myoglobin
NEFA
Phosphorus
Rheumatoid Factor (RF)
Superoxide Dismutase (Ransod)
Transthyretin (Prealbumin)
Total Protein
Transferrin
Uric Acid
Urinary Protein
Zinc

Email Us

Get in touch with Randox via email at reagents@randox.com

Need Instructions?

Download kit Inserts free on our online portal.

Buy Online

Order your reagents kits online by visiting our online store 


Hitachi 917/Modular P

Randox Acetaminophen Reagent

Applications for Hitachi 917 / Modular P

Randox have developed a range of applications for the Hitachi 917 and Modular P analysers so that laboratories worldwide can enjoy the benefits of freedom of choice from an independent manufacturer.

Hitachi 917 / Modular P Applications

We have 90 reagents available for the Hitachi 917 and Modular P, and are always developing more. If you don’t see the application you are looking for, please email us to request an application. All kits are produced to international standard and have ISO 13485 accreditation.

Albumin
Aldolase
Alkaline Phosphatase
ALT
Ammonia
Amylase
Apolipoprotein A-I
Apolipoprotein A-II
Apolipoprotein B
Apolipoprotein C-II
Apolipoprotein C-III
Apolipoprotein E
ASO
AST
ß2 Microglobulin
Bile Acids
Bilirubin
Calcium
Carbamazepine
Cholesterol Total
Cholesterol HDL
Cholesterol LDL
Cholesterol sdLDL
Cholinesterase (Butyryl)
CK-MB
CK-NAC
CO2
Total
Complement C3
Complement C4

Copper
Creatinine
CRP
CRP Canine
CRP Full Range
CRP High Sensitivity
Cystatin C
D-3 Hydroxybutyrate (Ranbut)
Digoxin
Ethanol
Ferritin
Fructosamine (Glycated Protein)
G6PDH
Gamma GT
GLDH
Glucose
Glucose / Fructose
Glutamate
Glutamine
Glutathione Peroxidase (Ransel)
Glutathione Reductase
Glycerol
Haptoglobin
HbA1c
Homocysteine
IgA
IgE
IgG
IgM
Iron

L-Lactate
LD Lactate – Pyruvate
LD Pyruvate – Lactate
Lipase
Lipoprotein (a)
Magnesium
Microalbumin
Myoglobin
NEFA
Phenobarbital
Phenytoin
Phosphorus
Potassium
Rheumatoid Factor (RF)
Sodium
Superoxide Dismutase
(Ransod)
Total Antioxidant Status
(TAS)
Total Iron Binding
Capacity (TIBC)
Total Protein
Transferrin
Transthyretin (Prealbumin)
Triglycerides
Urea
Uric Acid
Urinary Protein
Valproic Acid
Zinc

Email Us

Get in touch with Randox via email at reagents@randox.com

Need Instructions?

Download kit inserts for free on our online portal

Buy Online

Order reagents kits online by visiting our online store 


Request a meeting
×
Make an Enquiry - RX series
×
Make an Enquiry - Reagents
×
Kit Insert Request - Reagents
  • Signing up to our mailing list is quick and easy. We do not wish to send you any spam or junk email, therefore, you can expect to receive mailshots including new product launches and updates, market trends, attendance at key industry events and much more. Randox Laboratories promise never to sell your data and we will keep all your details, safe and secure. Read more in our Privacy Policy.
×
Kit Insert Request - Reagents
  • Signing up to our mailing list is quick and easy. We do not wish to send you any spam or junk email, therefore, you can expect to receive mailshots including new product launches and updates, market trends, attendance at key industry events and much more. Randox Laboratories promise never to sell your data and we will keep all your details, safe and secure. Read more in our Privacy Policy.
×
Make an Enquiry - Reagents
×
Make an Enquiry - Quality Control
×
Make an Enquiry - RIQAS
×
Make an Enquiry - RIQAS
×
Make an Enquiry - Quality Control
×
Make an Enquiry
  • Signing up to our mailing list is quick and easy. We do not wish to send you any spam or junk email, therefore, you can expect to receive mailshots including new product launches and updates, market trends, attendance at key industry events and much more. Randox Laboratories promise never to sell your data and we will keep all your details, safe and secure. Read more in our Privacy Policy.
×
Make an Enquiry - Biochip
  • This field is for validation purposes and should be left unchanged.
×
Make an Enquiry - Molecular
  • Signing up to our mailing list is quick and easy. We do not wish to send you any spam or junk email, therefore, you can expect to receive mailshots including new product launches and updates, market trends, attendance at key industry events and much more. Randox Laboratories promise never to sell your data and we will keep all your details, safe and secure. Read more in our Privacy Policy.
  • This field is for validation purposes and should be left unchanged.
×
Make an Enquiry - Future Diagnostics
×
Make an Enquiry - RX series (Product)
×
Make an Enquiry - Quality Control
  • Signing up to our mailing list is quick and easy. We do not wish to send you any spam or junk email, therefore, you can expect to receive mailshots including new product launches and updates, market trends, attendance at key industry events and much more. Randox Laboratories promise never to sell your data and we will keep all your details, safe and secure. Read more in our Privacy Policy.
×
Make an Enquiry - RIQAS
  • Signing up to our mailing list is quick and easy. We do not wish to send you any spam or junk email, therefore, you can expect to receive mailshots including new product launches and updates, market trends, attendance at key industry events and much more. Randox Laboratories promise never to sell your data and we will keep all your details, safe and secure. Read more in our Privacy Policy.
×
Make an Enquiry - Reagents
  • Signing up to our mailing list is quick and easy. We do not wish to send you any spam or junk email, therefore, you can expect to receive mailshots including new product launches and updates, market trends, attendance at key industry events and much more. Randox Laboratories promise never to sell your data and we will keep all your details, safe and secure. Read more in our Privacy Policy.
×
Por favor, introduzca sus datos para ver nuestro último seminario
×
Wyślij zapytanie
  • Rejestracja na naszej liście mailowej jest szybka i łatwa. Nie chcemy wysyłać e-maili zawierających spam lub wiadomości, które są automatycznie przekierowywane do kosza. W zawiązku z czym firma Randox deklaruje, że będzie wysyłac tylko informacje na temat nowych produktów,akutalizacji obecnych, trendów rynkowych, wydarzeń branżowych itp. Firma Randox Laboraotries obiecuje, że Państwa dane nie będą nigdzie przekazane, a przechowywanie owych danych będzie się odbywało z zachowaniem największego bezpieczeństwa. Prosimy o przeczytani naszje Polityki Prywatności.
×
Wyślij zapytanie
  • Rejestracja na naszej liście mailowej jest szybka i łatwa. Nie chcemy wysyłać e-maili zawierających spam lub wiadomości, które są automatycznie przekierowywane do kosza. W zawiązku z czym firma Randox deklaruje, że będzie wysyłac tylko informacje na temat nowych produktów,akutalizacji obecnych, trendów rynkowych, wydarzeń branżowych itp. Firma Randox Laboraotries obiecuje, że Państwa dane nie będą nigdzie przekazane, a przechowywanie owych danych będzie się odbywało z zachowaniem największego bezpieczeństwa. Prosimy o przeczytani naszje polityki prywatności.
×
Wyślij zapytanie
  • Rejestracja na naszej liście mailowej jest szybka i łatwa. Nie chcemy wysyłać e-maili zawierających spam lub wiadomości, które są automatycznie przekierowywane do kosza. W zawiązku z czym firma Randox deklaruje, że będzie wysyłac tylko informacje na temat nowych produktów,akutalizacji obecnych, trendów rynkowych, wydarzeń branżowych itp. Firma Randox Laboraotries obiecuje, że Państwa dane nie będą nigdzie przekazane, a przechowywanie owych danych będzie się odbywało z zachowaniem największego bezpieczeństwa. Prosimy o przeczytani naszje polityki prywatności.
×
Wyślij zapytanie
    Rejestracja na naszej liście mailowej jest szybka i łatwa. Nie chcemy wysyłać e-maili zawierających spam lub wiadomości, które są automatycznie przekierowywane do kosza. W zawiązku z czym firma Randox deklaruje, że będzie wysyłac tylko informacje na temat nowych produktów,akutalizacji obecnych, trendów rynkowych, wydarzeń branżowych itp. Firma Randox Laboraotries obiecuje, że Państwa dane nie będą nigdzie przekazane, a przechowywanie owych danych będzie się odbywało z zachowaniem największego bezpieczeństwa. Prosimy o przeczytani naszje polityki prywatności .
×
귀하의 문의 사항 제출
    Signing up to our mailing list is quick and easy. We do not wish to send you any spam or junk email, therefore, you can expect to receive mailshots including new product launches and updates, market trends, attendance at key industry events and much more. Randox Laboratories promise never to sell your data and we will keep all your details, safe and secure. Read more in our Privacy Policy.
×
귀하의 문의 사항 제출
×
귀하의 문의 사항 제출
×
귀하의 문의 사항 제출
×
Downloads
×
Contact

<p>