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Apolipoprotein C-III (Apo C-III) Assay

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Apolipoprotein C-III (Apo C-III) Assay

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Reagent | Apolipoprotein C-III (Apo C-III)

An Independent Risk Factor for CVD

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Benefits of the Randox Apo C-lll Assay

Limited Interference

Immunoturbidimetric method

The immunoturbidimetric method limits interference from Bilirubin, Haemoglobin, Intralipid® and Triglycerides, producing more accurate results.

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Exceptional correlation

A correlation coefficient of r=1.00 was displayed when the Randox apo C-III assay was compared to commercially available methods.

Wide Measuring Range

Excellent measuring range

The Randox apo C-III assay has a measuring range of 2.06 – 21.7mg/dl for the comfortable detection of clinically important results.

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Liquid ready-to-use

The Randox apo C-III assay is available in a liquid ready-to-use format for convenience and ease-of-use.

Calibrator & Controls

Dedicated calibrator and controls available

Randox offer dedicated apolipoprotein calibrator and controls for a complete testing package.

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Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox apo C-III assay on a variety of clinical chemistry analysers.

Ordering Information

Cat NoSize    
LP3865R1 2 x 11ml
R2 2 x 5ml		EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Clinical Significance

Not only is apo C-III a key regulator in the metabolism of triglycerides, but it is also an independent risk factor for CVD. Not only does apo C-III contribute to CVD through the regulation of triglycerides but also through its direct atherogenic effects, promoting atherosclerosis (fig 1) 1.

Fig. 1. Pleiotropic effects of apo C-III 1
Fig. 1. Pleiotropic effects of apo C-III

Physiological Significance

Apo C-III is composed of 79 amino acids and has a molecular weight of 8.8kDa. Apo C-III promotes hypertriglyceridemia via several mechanisms. Firstly, like apo C-II, apo C-III also inhibits the activity of LPL, distributing lipid lipolysis. Apo C-III hinders the binding of apolipoprotein B and apolipoprotein E to the hepatic receptors resulting in the delayed catabolism of triglyceride – rich lipoproteins (TRLs). Finally, apo C-III prefers the production and secretion of very low-density lipoproteins (VLDL) in the liver 1.

Useful links

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Apolipoprotein Calibrator

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IgG

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Reagent | IgG

Key Benefits of IgG

Excellent precision

The IgG assay showed a precision of less than 4% CV

Exceptional correlation

The assay showed a correlation of r=0.99 against another commercially available method

Completely automated protocols

Available for a range of analysers

Other features

  • Immunoturbidimetric method
  • Liquid ready-to-use reagents
  • Open vial stability of 28 days at 10⁰C
  • Measuring range 1.61 – 56 g/l

Ordering information

Cat NoSize    
IG3833R1 3 x 20ml
R2 3 x 14ml		EnquireKit Insert RequestMSDSBuy Online
IG8044R1 4 x 8.7ml
R2 4 x 3.9ml		EnquireKit Insert RequestMSDSBuy Online

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is IgG used for?

Measurement of immunoglobulin G is the basis of the serological diagnosis of several infectious diseases. Uses of IgG measurement include diagnosis of infectious and inflammatory diseases, diagnosis of malignancies, to detect the presence of soluble antigens and monitoring therapy in myeloma.

The Randox IgG assay is an immunoturbidimetric end-point method for manual use and on automated analysers. The increase in turbidity in a sample containing human IgG is measured at 340 nm.

Related products

Related Products

Specific Proteins Panel

For more information or to view more reagents within the specific proteins panel, please click here

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