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Urinary Tract Infection (UTI)

Rapid Diagnostic Point of Care Test for UTI Detection

Timely Identification of UTIs, Facilitating Improved, Targeted Treatment

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    Species level identification and complete patient profiling from a single urine sample
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    The Randox UTI array includes a MecA antibiotic resistance marker to assist antibiotic stewardship
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    Detecting 23 bacterial, 1 fungal and 8 resistance markers

     

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    Same-day results to facilitate health professionals in their selection of most appropriate treatment approach for patients

     

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    Assay run time from DNA extraction to data interpretation in under 4 hours

     

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    Identification of significant UTI bacteria which cannot be recognised through traditional nitrite and leukocyte dipstick tests

     

     

A UTI is defined as the detection of a micro-organism in the urine, measured from a midstream urine sample, with presence of clinical symptoms. UTIs occur when a micro-organism migrates from the urethra to the bladder or kidney.

The Urinary Tract Infections (UTI) array is a market leading test detecting 30 bacterial, fungal and associated antibiotic resistance markers from a single urine sample. Identification of a multiplex UTI can prevent further damage to the renal system including the kidneys and bladder.

Biochip

Biomarkers Tested

Bacteria

  • Acinetobacter baumannii
  • Escherichia coli
  • Citrobacter freundii
  • Citrobacter koseri
  • Klebsiella oxytoca
  • Klebsiella pneumoniae
  • Klebsiella aerogenes
  • Serratia marcescens
  • Staphylococcus aureus
  • Staphylococcus epidermidis
  • Staphylococcus saprophyticus
  • Streptococcus agalactiae (GBS)
  • Morganella morganii
  • Enterobacter cloacae
  • Enterococcus faecalis
  • Enterococcus faecium
  • Proteus spp.
  • Providencia stuartii
  • Providencia rettgeri
  • Pseudomonas aeruginosa

Acinetobacter is a genus of Gram-negative bacteria belonging to the wider class of Gammaproteobacteria. It is present in the environment and can live on human skin. Some types can cause blood, lung or urinary tract infections.

Also known as E. coli, is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms.

A species of facultative anaerobic gram-negative bacteria of the family Enterobacteriaceae.

A gram-negative, non-lactose fermenting rod that is often part of normal human flora, the urinary tract is one of the most common sites of infection by Citrobacter.

KO is one of several Klebsiella bacteria. It is an emerging bacterial isolate causing hospital-acquired infections in adults and having multiple drug resistance to commonly used antibiotics.

Bacteria that normally live in your intestines and faeces. These bacteria are harmless when they’re in your intestines. But if they spread to another part of your body, they can cause severe infections.

Previously known as Enterobacter aerogenes, is a Gram-negative, oxidase negative, catalase positive, citrate positive, indole negative, rod-shaped bacterium.

A species of rod-shaped, Gram-negative bacteria in the family Yersiniaceae. It is a facultative anaerobe and an opportunistic pathogen.

The most dangerous of all of the many common staphylococcal bacteria. These gram-positive, sphere-shaped (coccal) bacteria often cause skin infections but can cause pneumonia, heart valve infections, and bone infections.

A common bacterial colonisers of the skin and mucous membranes of humans and other mammals.

A gram-positive, coagulase negative, non-hemolytic coccus that is a common cause of uncomplicated urinary tract infections.

A gram-positive, β-hemolytic organism in the Streptococcus genus that carries the Lancefield group B antigen.

Belongs to the tribe Proteeae of the Enterobacteriaceae family. This species is considered as an unusual opportunistic pathogen that mainly causes post-operative wound and urinary tract infections.

A member of the normal gut flora of many humans and is not usually a primary pathogen. Some strains have been associated with urinary tract and respiratory tract infections in immunocompromised individuals.

Formerly classified as part of the group D Streptococcus system – is a Gram-positive, commensal bacterium inhabiting the gastrointestinal tracts of humans and other mammals.

Contains decarboxylase enzymes that use both l-phenylalanine and l-tyrosine as substrates, producing 2-phenylethylamine and p-tyramine.

Are Gram-negative bacteria belonging the Enterobacteriaceae family and are common commensals of the gastrointestinal microbiota.

An opportunistic pathogen being the most common cause of catheter-associated urinary tract infections.

Can be identified by its motility and its ability to produce acid from mannitol.

A common encapsulated, Gram-negative, rod-shaped bacterium that can cause disease in plants and animals, including humans.

Fungi

  • Candida albicans

The most prevalent fungal species of the human microbiota; this species asymptomatically colonizes many areas of the body, particularly the gastrointestinal and genitourinary tracts of healthy individuals.

 

Antibiotic Resistance Markers

  • mecA (incl MRSA)
  • Trimethoprim Resistance 1-5
  • Vancomycin Resistance A/B

A gene found in bacterial cells which allows them to be resistant to antibiotics such as methicillin, penicillin and other penicillin-like antibiotics.

 

Can be caused by changes in cell permeability, loss of bacterial drug-binding capacity, and overproduction of or alterations in dihydrofolate reductase.

Vancomycin acts by binding to d-Ala-d-Ala pentapeptides blocking cell wall biosynthesis. Resistance to vancomycin is conferred by the van operon, which consists of a two-component regulatory system (vanS-vanR) that responds to either vancomycin, disruption at the cell membrane, or both.

Available Platforms

Evidence Investigator

The Evidence Investigator is a compact, semi-automated benchtop analyser that offers efficient and comprehensive testing. Renowned for its versatility, robustness and effective reporting methods, the Evidence Investigator has been used in a wide range of laboratory settings for over 15 years.

 

The Vivalytic platform is a universal, fully automated all in one solution for molecular diagnostics. It is a cartridge-based platform enabling Hi-Plex and Lo-Plex testing, consolidating the full molecular workflow into a small benchtop platform, capable of extraction, PCR amplification and detection.

 

Want to know more?

Contact us or visit our Investigator Webpage

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