Randox Alzheimer’s Disease Array

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Rapid Alzheimer’s Disease Risk, Diagnosis & Prognosis

Rapid Alzheimer's Disease Risk, Diagnosis & Prognosis

Identification of Alzheimer’s disease risk in under 3 hours

Direct Apo E ‘genotyping’ from a simple plasma sample without the need for molecular genotyping

Ensures better outcomes, guaranteeing timely therapeutic intervention

Patented biochip technology simultaneously detects Apo E and Apo E4 proteins from a single patient sample

Delivers valuable information for use in research, personalised medicine and development of novel therapeutics

Suitable for use on the Evidence Investigator, a semi-automated analyser

The Randox Alzheimer’s Disease Array is a rapid and highly sensitive blood test facilitating direct Apo E genotyping without the need for molecular testing. Apo E is present in three common isoforms; Apo E2, Apo E3 and Apo E4. As such, six common Apo E genotypes exist in the general population. Alzheimer’s Disease risk is increased in individuals with the Apo E4 allele. The following diagram provides an indication of risk based on the six common genotypes.

Utilising revolutionary patented Biochip Technology, the Randox Alzheimer’s Disease Array provides a unique solution for the measurement of both total apoE and the apo E4 isoform levels from a single patient sample, facilitating the fast and accurate classification of Alzheimer’s disease risk in comparison to brain scanning (CT and MRI).

Biomarkers Tested

Apo E is recognised as one of the most powerful genetic risk factors for dementia and other neurodegenerative diseases. For this reason, Apo E is widely studied in relation to Alzheimer’s disease. There are three common isoforms of Apo E; Apo E2, Apo E3, and Apo E4.

Apo E is a major cholesterol carrier, responsible for lipid homeostasis by mediating lipid transport from one tissue or cell type to another. In the central nervous system, Apo E is mainly produced by astrocytes, and transports cholesterol to neurons via Apo E receptors.

Apo E4 is one of three common isoforms of Apo E and is recognised as a major genetic risk factor the development of Alzheimer’s disease. Apo E4 triggers inflammatory cascades that cause neurovascular dysfunction, including blood-brain barrier breakdown, leakage of blood-derived toxic proteins into the brain and reduction in the length of small vessels.

The Evidence Investigator

Meet the Evidence Investigator

The Randox Alzheimer’s Disease Array is a research use-only product developed for the Evidence Investigator, a semi-automated benchtop immunoassay analyser.

The Alzheimer’s Disease Array measures both total Apo E and Apo E4 protein levels directly from plasma samples, to identify whether patients are Apo E4 heterozygous, homozygous or null. By using a ratio, it can classify patients as negative or positive for Apo E4. In turn, the patients risk for the development of Alzheimer’s Disease can be assessed.