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Randox ApoE4 Array (EV4113)

Rapid Identification of Alzheimer’s Disease Risk

Rapid Identification of Alzheimer's Disease Risk

  • Identification
    Identification of Alzheimer’s disease risk in under 3 hours
  • Direct ApoE
    Direct determination of ApoE4 status from a plasma sample eliminates the need for molecular genotyping
  • Better Outcomes
    Potential to improve quality of life and care for dementia patients through lifestyle and therapeutic interventions
  • Biochip
    Patented Biochip Array Technology simultaneously measures total ApoE and ApoE4 protein levels directly from a plasma sample
  • Valuable Information
    100% concordance with molecular genotyping
  • Investigator
    Applicable to Alzheimer’s research, personalised medicine and the development of Alzheimer’s therapeutics

The Randox ApoE4 Array is a rapid and highly sensitive blood test facilitating direct ApoE4 genotyping without the need for molecular genotyping.  ApoE exists as three common isoforms; ApoE2, ApoE3 and ApoE4.   As such, six common ApoE genotypes exist in the general population.  Alzheimer’s Disease risk is significantly increased in individuals with the ApoE4 allele.  The below table provides an indication of risk associated with the six common ApoE genotypes.

Biochip
Alzheimer's Disease Risk Table

Biomarkers Tested

  • Pan ApoE
  • Apo E4

ApoE is a major cholesterol carrier, responsible for lipid homeostasis by mediating lipid transport from one tissue or cell type to another. In the central nervous system, ApoE is mainly produced by astrocytes, and transports cholesterol to neurons via ApoE receptors.  ApoE exists as three common isoforms; ApoE2, ApoE3 and ApoE4.

 

ApoE4 is established as the strongest genetic risk factor for Alzheimer’s Disease.   ApoE4 triggers inflammatory cascades that cause neurovascular dysfunction, including blood-brain barrier breakdown, leakage of blood-derived toxic proteins into the brain and reduction in the length of small vessels.

Apo E4 is one of three common isoforms of Apo E and is recognised as a major genetic risk factor the development of Alzheimer’s disease.   Apo E4 triggers inflammatory cascades that cause neurovascular dysfunction, including blood-brain barrier breakdown, leakage of blood-derived toxic proteins into the brain and reduction in the length of small vessels.

The Evidence Investigator

Meet the Evidence Investigator

The Randox ApoE4 Array (EV4113) is a research use-only product developed for the Evidence Investigator, a semi-automated benchtop immunoassay analyser.

The ApoE4 Array (EV4113) simultaneously measures both total ApoE and ApoE4 protein levels directly from a plasma sample.  The Apo E4/total ApoE ratio can classify the ApoE4 status of the plasma sample as negative or positive.  Furthermore, the Array has demonstrated potential to classify ApoE4 positive plasma samples as being derived from a heterozygous (one copy of ApoE4 gene) or a homozygous (two copies of ApoE4 gene) individual.  Therefore, risk for the development of Alzheimer’s Disease can be assessed.

Evidence Investigator

Publications

Want to know more?

Contact us or visit our Cerebral Array webpage.

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