Exceptional correlation with standard methods

The Randox methodology was compared against other commercially available methods and the Randox Chloride assay showed a correlation coefficient of r=0.98

Excellent sensitivity

The healthy lower level of chloride is 96 mmol/l. The Randox assay can comfortably detect levels outside of this lower level with a sensitivity of 35.8 mmol/l.

Excellent stability

Stable until expiry date when stored at +15 to +25°C

• Mercuos (II)-Thiocyanate method
• Liquid ready-to-use reagents
• Stable to expiry when stored at +15 to +25°C
• Measuring range
  • 35.8 – 205 mmol/l in serum
  • 58.2 – 168 mmol/l in urine

What is chloride?

Chloride is one of the most important essential electrolytes found in the blood and regulated by the kidneys. It represents 70% of the body’s total negative ion content. It is responsible for keeping a healthy balance between fluid and acid within the body. Negatively charged chloride ions are responsible for aiding in the central nervous system with the transportation of electrical impulses throughout the body. In the stomach, it binds to hydrogen to form hydrochloric acid which is a powerful digestive enzyme. Hydrochloric acid is responsible for the breaking down of protein, absorption of metallic minerals, and the activation of the intrinsic factor which absorbs vitamin B12.  Some of the chloride is then reabsorbed back into the bloodstream from the small intestine to continue with its ion functions.

It is important that the levels of chloride, potassium and sodium are consistently balanced as this regulates the pH of the body which is crucial for the functioning of the heart, nerves, muscles, and the excretion and absorption of bodily fluid.

What is the chloride assay used for?

The Randox Chloride assay is used to detect electrolyte imbalances of chloride within the blood for the diagnosis of certain conditions.

Hypochloremia is an electrolyte imbalance caused as a result of low levels of chloride in the blood.  Hypochloremia is usually caused as a result of kidney problems but it can also be attributed to chronic lung diseases such as emphysema, metabolic alkalosis or congestive heart failure. For more information on hypochloremia, please click here [external link].

Hyperchloremia is the result of high levels of chloride within the blood. Hyperchloremia, like hypochloremia, is commonly attributed to kidney problems but can also be caused as a result of ingestion of salt water, diabetes, bromide poisoning, and the long-term usage of carbonic anhydrase inhibitors. For more information on hyperchloremia, please click here [external link].