Complement C4 Reagent

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Key Benefits of the Randox Complement C4 reagent

Exceptional correlation with standard methods

The Randox methodology was compared against other commercially available methods and the Randox Complement C4 assay showed a correlation coefficient of r=0.98

Wide measuring range

The healthy range for Complement C4 is 7 -49 mg/dl. The Randox Complement C4 assay can comfortably detect levels outside of the healthy range measuring between 2.90 – 152 mg/dl.

Excellent stability

Stable until expiry date when stored at +2 to +8°C

Other features of the Randox Complement C4 reagent

  • Immunoturbidimetric method
  • Liquid ready-to-use reagents
  • Stable until expiry date when stored at +2 to +8°C
  • Measuring range 2.90 – 152 mg/dl
Cat NoSizeAnalyserEasy Read
Easy Fit
 
CM3846R1 3 x 20ml
R2 3 x 6ml
RX Daytona/Imola
Hitachi 717/911/912/704/902


CM8024R1 2 x 9.6ml
R2 2 x 4.2ml
RX Suzuka
Abbott Architect
Hitachi 917/Mod P
Konelab 20i/30i/60i
Beckman Coulter AU Series








CM8349R1 1 x 14.2ml
R2 1 x 4.9ml
RX Daytona +/Monaco
Abbott Architect
Hitachi 917/Mod P
Konelab 20i/30i/60i
Beckman Coulter AU Series








Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the Complement C4 assay used for?

What is Complement C4?

The complement system is one of the major mechanisms of innate immunology consisting of more than 30 plasma and membrane-associated serum proteins which evokes cytolytic immune responses to pathogens, including viruses, bacteria, chemical tissue damage and anything that is classified as foreign to the body. The complement system can be activated through three major pathways: classical, lectin or alternative. Once activated, reactions occur for antibody opsonisation (the process by which a phagocyte marks a pathogen for ingestion and elimination) to fight against the foreign bodies.  Activation can also occur when the body produces antibodies for its own tissues that it views as being foreign, which is known as an autoimmune disorder.

During the activation process, Complement C4 splits down into C4b and C4a (peptide). C4b acts as an opsonin and remains bound to the complex at the surface of the pathogen which activates the next step of the process. The small peptide, C4a diffuses away and acts as a chemotactic factor and an inflammatory paracrine.

What is the Complement C4 assay used for?

The Randox Complement C4 assay is used for the quantitative in vitro determination of complement C4 concentration in serum.  The Randox Complement C4 assay allows for the diagnosis and monitoring of autoimmune disorders associated with abnormal levels of complement C4 including lupus and rheumatoid arthritis (RA).  Higher than normal results may be indicative of cancer or ulcerative whereas lower than normal results may be indicative of lupus, hepatitis, or cirrhosis.

Cell-bound levels of processed complement activation products, especially E-C4d (erythrocyte-bound C4) is a biomarker in the diagnosis and monitoring of systematic lupus erythematous (SLE). For more information on SLE, please click here [external link].

Specific Proteins Panel

For more information or to view more reagents within the specific proteins panel, please click here

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