Cytokine Autoantigen
Multiplexed anti-cytokine auto-antibody assay developed to provide a comprehensive diagnostic and prognostic solution to stratify disease, monitor disease activity and inflammatory responses. The Randox panel, showcases improved biomarker sensitivity and specificity, capable of being used for therapeutic targeting in areas such as autoimmune syndromes, aid in the prevention of antibiotic overuse, inflammatory disease conditions and certain cancers.
Detection of anti-cytokine auto-antibodies underpinning for example an autoimmune episode would allow identification of historically active, recently reactivated or potentially impaired inflammatory pathways.
Anti-cytokine auto-antibodies can complement functional serology, cytokine monitoring and genetic testing in the characterization of a patients immune function.
The need – differentiating between autoimmune and infectious diseases.
One of the challenges in diagnosing inflammatory conditions is distinguishing between autoimmune diseases (which can trigger cytokine imbalances) and infections (which can also elevate cytokine levels). In certain cases, especially in individuals with complex medical histories, it might be difficult to differentiate between an infection and a flare-up of an autoimmune disease.
Anti-cytokine auto antibodies could provide insights into whether a cytokine imbalance is due to an autoimmune process, thereby reducing the likelihood of a mistaken diagnosis of infection.
Assessment can also be beneficial for improved diagnostic accuracy in immune-mediated diseases such as rheumatoid arthritis, systemic lupus erythematosus, or inflammatory bowel disease. Anti-cytokine auto antibody tests could refine diagnosis, allowing for more targeted treatments, such as immunosuppressive drugs instead of antibiotics.
Reducing Misuse of Antibiotics in Chronic Inflammatory Diseases is critical to the global AMR crisis. Clinicians could use anti-cytokine autoantibodies to better understand the underlying cause of these symptoms, they might be less likely to prescribe antibiotics inappropriately, whilst also understanding and identifying cases of cytokine storm in severe infections.
In some cases, cytokine storm may occur due to infections like sepsis or viral infections (e.g., COVID-19). Cytokine storm is often accompanied by excessive cytokine release, and measuring anti-cytokine autoantibodies could help distinguish between an immune response driven by infection and one driven by an underlying autoimmune condition.
Supporting Personalised Medicine Approaches
Personalised or precision medicine aims to tailor treatments based on individual patient profiles, including the presence of auto antibodies. By integrating anti-cytokine auto antibody testing into clinical decision-making, physicians can provide more targeted therapies (e.g., immunomodulatory treatments) and avoid broad-spectrum antibiotics when not needed.
Therapeutic approaches targeting anti-cytokine autoantibodies
Randox Cytokine Autoantigen Array
Randox biochip array offers an ideal platform for clinical application of autoantibody detection. Anti-Cytokine Autoantibody multiplex detection panel can complement functional serology, cytokine monitoring and genetic testing in the characterization of immune function.
Meet the Evidence Investigator
Renowned for its versatility, robustness and effective reporting methods, the Evidence Investigator is a semi-automated, benchtop platform that offers efficient and comprehensive testing without compromising accuracy.
Using chemiluminescent as a measurement principle, the Evidence Investigator consistently delivers accurate results.
All data is analysed on-board, removing issues related to human error and result manipulation.
Meet the Biochip
Biochip Technology from Randox utilises multiplex testing methodology in a rapid, accurate and easy-to-use format, catering both molecular and immunoassay testing.
Each biochip can have up to 49 Discrete Test Regions (DTR), meaning that 44 tests can be carried out simultaneously.
Using protein and DNA based biochips provides the user the ability to consolidate tests.