A Stable-Side Device Designed to Measure Equine Serum Amyloid A & Detect Inflammation


Veterinary Diagnostic Reagents

High Quality Open Channel Tests, Validated For Veterinary Use

Benefits of Randox Diagnostic Veterinary Reagents

Comprehensive Tests Menu

Comprehensive Test Menu

A comprehensive test menu encompassing 48 diagnostic veterinary assays, including a variety of assays unique to Randox

Superior Performance

Superior Methodology

Superior methodologies ensuring accurate & reliable results compared to traditional methods

Reduce Costs

Reduce Costs

Versatile test menu enabling laboratories to reduce costs with in-house testing

Excellent Correlations

Excellent Correlations

Excellent correlations to gold standard & commercial methods, providing confidence in patient results

Validated icon

Validated For Use

The Randox diagnostic veterinary reagents are scientifically proven and validated for use with a diverse range of animal species

Applications Available

Applications Available

Applications available detailing instrument-specific settings for the convenient use of Randox Veterinary Reagents on a variety of clinical chemistry analysers

Open Channel Diagnostic Veterinary Reagents

  • A-Z Test Menu
  • Superior Performance & Unique Tests Menu
Alanine Aminotransferase (ALT)Cholesterol (LDL)GlucoseSodium
AlbuminCholesterol (Total)Glutathione Peroxidase (Ransel)Superoxide Dismutase (Ransod)
AldolaseCholinesterase (Butyryl)Glutathione ReductaseTotal Antioxidant Status (TAS)
Alkaline PhosphataseCK-NACIronTotal Iron Binding Capacity (TIBC)
AmmoniaCO2 TotalLactateTotal Protein
AmylaseCopperLactate Dehydrogenase (L-P)Triglycerides
Aspartate Aminotransferase (AST)CreatinineLactate Dehydrogenase (P-L)Urea
Bile Acids (4th Gen)CRP (Canine)LipaseUric Acid
Bile Acids (5th Gen)D-3 Hydroxybutyrate (Ranbut)MagnesiumUrinary Protein
Bilirubin (Direct)FructosamineNEFAZinc
Bilirubin (Total)Gamma GTPhosphorus (Inorganic)
Cholesterol (HDL)GLDHPotassium
AldolaseCRP (Canine)Glutathione Peroxidase (Ransel)Superoxide Dismutase (Ransod)
Bile Acids (5th Gen)Creatinine (Enzymatic)Glutathione ReductaseTotal Antioxidant Status (TAS)
CopperD-3-Hydroxybutyrate (Ranbut)Non-Esterified Fatty Acids (NEFA)Zinc

Product availability may vary from country to country. Some product may be for Research use Only. For more information on product application and availability, please contact your local Randox Representative.

Superior Performance & Unique Diagnostic Veterinary Reagents

Copper is one of the several essential trace elements in animal life required for red and white blood cell formation, healthy nerve fibres, pigmentation, wool growth and bone growth 1. In animals, whilst copper deficiency is one of the most commonly diagnosed trace element deficiencies, over-supplement of copper can lead to copper toxicity 2.

Copper deficiency is common in bovines, mainly cattle and sheep, caused by two factors: low copper levels in plants in copper-deficient soils, and an induced deficiency due to ingesting excessive levels of other elements, including: sulphur, iron and molybdenum in feed supplements or pastures 1.

On the other hand, bovines such as sheep and calves prior to weaning are the most susceptible to copper toxicity. This can occur as a result over excessive ‘therapeutic’ amounts of copper are added to the feed to avoid copper deficiency, however, it’s more commonly the result of long-term ingestion of copper in quantities which exceed the nutritional requirements 3.

Diabetes mellitus (DM), is commonly observed in middle aged and older canines and felines. Certain conditions predispose canines and felines to DM, including being overweight, inflammation of the pancreas, and certain medications which interfere with insulin, such as glucocorticoids. DM can also occur in the young which is attributed to a genetic factor. DM is more commonly observed in female canines and male felines 4.

Fructosamine testing is utilised to evaluate a canine or feline’s response to treatment which provides the canine or feline’s average glucose concentrations for the previous 7 to 14 days 5.

The NBT method is commonly utilised in fructosamine testing, however Randox offer the enzymatic method which improves specificity and reliability. The Randox enzymatic fructosamine assay displayed a correlation coefficient of r=0.9192 when compared to the NBT method.

Non-esterified fatty acids (NEFA) reflects the energy status of animals, with high NEFA concentrations indicating a negative energy balance. A negative energy balance occurs when caloric intake is lower than energy expenditure. High serum NEFA concentrations and a negative energy balance are risk factors for metabolic disease 6.

Energy balance is one of the most critical nutritional factors affecting animal health, reproductive performance and lactation 7.  A negative energy balance has been observed in several animal species and should be observed especially in bovine (cattle, goats, sheep), feline and equines.

Superoxide dismutase (SOD) is an enzyme responsible for catalysing the dismutation of superoxide radicals (O2-), a primary reactive oxygen species (ROS) produced by the body, to hydrogen peroxidase (H2O2) and molecular oxygen (O2), the inadvertent by-products of aerobic metabolism. Consequently, SOD plays an integral role in protecting the body from oxidative stress 8, 9, 10.

SOD measurement is particularly useful in endurance horses as oxidative stress increases with prolonged endurance training. Decrease levels of SOD can cause fatigue, muscle damage, stiffness, and decreased performance 11.

SOD measurement is also useful in dairy cows who experience oxidative stress and a reduce antioxidant defence capacity during postpartum period and lactation 12.

Zinc is an essential trace mineral in animals and is required for the normal functioning of organisms. Involved in several biochemical processes, including: RNA and DNA expression and cellular use of oxygen and respiration, sequestration of free radicals, protection against lipid peroxidation and maintenance of cell membrane integrity 13.

In canines, zinc is not easily or readily absorbed in the intestines. The absence of zinc in canines causes various abnormalities affecting the immune system, metabolic function and the skin. Moreover, zinc deficiency can cause zinc responsive dermatosis, a keratinisation disorder (abnormal skin production) 14.

Zinc toxicity has been observed in exotic, large and wild animals due to dietary indiscretions. Zinc toxicity causes decreased weight and milk production in large animals and lameness and epiphyseal in foals 15.

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1]  Michigan State University. Nutrition Diagnostics For Dairy Cattle. https://cvm.msu.edu/vdl/laboratory-sections/nutrition/nutrition-diagnostics-for-dairy-cattle (accessed 11 November 2019).

[2]  Van Saun RJ. Food Animal Practice. : Saunders WB; 2009. http://www.sciencedirect.com/science/article/pii/B9781416035916100405 (accessed 11 November 2019).

[3]  Erickson E. Copper deficiency in sheep and cattle. https://www.agric.wa.gov.au/feeding-nutrition/copper-deficiency-sheep-and-cattle (accessed 11 November 2019).

[4]  Washington State University. Diabetes Mellitus. https://www.vetmed.wsu.edu/outreach/Pet-Health-Topics/categories/diseases/diabetes-mellitus (accessed 14 November 2019).

[5]  NADIS Animal Health Skills. Chronic Copper Toxicity. https://www.nadis.org.uk/disease-a-z/cattle/chronic-copper-toxicity/ (accessed 11 November 2019).

[6]  Bidewell C, Livesey C. Copper poisoning: an emerging disease in dairy cattle. Veterinary Laboratories Agency ; (): 16-19. https://pdfs.semanticscholar.org/6282/64c8b58d44018a5527d5a58162e0bdf82e95.pdf (accessed 11 November 2019).

[7]  Williams K, Ruotsalo K, Tant MS, Downing R. Diabetes in Cats – Testing and Monitoring. https://vcahospitals.com/know-your-pet/diabetes-in-cats-testing-and-monitoring (accessed 14 November 2019).

[8]  Siddique T, Deng HX, Ajroud-Driss S. Motor Neuron Disease. Rimoin D, Pyeritz R, Korf B (eds). Emery and Rimoin’s Principles and Practice of Medical Genetics, 6th ed. : Elsevier Ltd; 2013. pp. 1-22.

[9]  Homma T, Fujii J. Oxidative Stress and Dysfunction of the Intracellular Proteolytic Machinery: A Pathological Hallmark of Nonalcoholic Fatty Liver Disease. Watson RR, Preedy VR (eds). Dietary Interventions in Liver Disease, 1st ed. : Elsevier Inc; 2019. pp. 59-70.

[10]  Imlay JA. Cellular Defenses against Superoxide and Hydrogen Peroxide. Annual Reviews 2008; 77(1): 755-776.

[11] Siqueira RF, Weigel RA, Nunes GR, Mori CS, Fernandes WR. Oxidative profiles of endurance horses racing different distances. Brazilian Journal of Veterinary and Animal Sciences 2014; 66(2): 455-461.

[12]  Feştilă I, Mireşan V, Răducu C, Cocan D, Constantinescu R. Evaluation of Oxidative Stress in Dairy Cows through Antioxidant Enzymes Glutathione Peroxidase (GPX) and Superoxide Dismutase (SOD) . Bulletin UASVM Animal Science and Biotechnologies 2012; 69(1-2): . http://journals.usamvcluj.ro/index.php/zootehnie/article/download/8396/7617 (accessed 21 Nov 19).

[13]  Sloup V, Jankovská I, Nechybová S, Peřinková P, Langrová I. Zinc In The Animal Organism: A Review*. Scientia Agriculturae Bohemica 2017; 48(1): 13-21.

[14]  Primovic D. Overview of Zinc Deficiency in Dogs. https://www.petplace.com/article/dogs/pet-health/dog-health/zinc-deficiency-zinc-responsive-dermatosis-in-dogs/ (accessed 21 November 2019).

[15]  Cahill-Morasco R. Overview of Zinc Toxicosis. https://www.msdvetmanual.com/toxicology/zinc-toxicosis/overview-of-zinc-toxicosis (accessed 21 November 2019).

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