C-reactive protein (CRP) is a well-established biomarker of inflammation. In circulation, CRP exists as a pentameric structure; however, at sites of tissue injury or infection it can dissociate into monomeric CRP (mCRP).

mCRP is considered the biologically active form and has been shown to promote pro-inflammatory signalling and immune cell activation. As a result, it is increasingly being investigated for its role in inflammatory and cardiovascular disease.

mCRP and Cardiovascular Disease

Inflammation plays a central role in the development of atherosclerosis and cardiovascular disease (CVD). mCRP has been detected within atherosclerotic plaques but not in healthy vessels, supporting its involvement in vascular inflammation.

Elevated plasma mCRP levels have been reported in patients with coronary artery disease and acute myocardial infarction, and have been associated with increased plaque burden.

These findings suggest that mCRP may serve as a novel marker of vascular inflammation and cardiovascular risk.