Randox – Infections

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Randox – Infections

Randox are dedicated to improving health worldwide. Throughout the month of September we hope to highlight how the Randox clinical product range can assess the impact of infection through swift diagnosis, allowing the necessary steps to be taken in order to improve an individual’s health. Infection is the infiltration of an organism’s bodily tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce. The Randox portfolio comprises a wide range of products to assess the impact of infection.  The RX series dedicated testing panel comprises of IgA, hsCRP and ASO which are also available for third-party use.  The extensive QC range caters for assessment of infectious disease testing in both liquid & lyophilised formats.

Reagents

The Randox range of third-party reagents enables the clinical analysis of 113 different analytes with comprehensive range measurements and excellent correlations to reference methods.  Applications are available detailing instrument-specific settings for a variety of biochemistry analysers.  Randox offer several assays for the detection of infection.

IgG (the most abundant antibody) and IgM (the first antibody made in response to infection) can be used in the diagnosis of Dengue Fever.  More than 40% of the global population, in more than 100 countries are at risk of the Dengue Virus (WHO).  IgA is an antibody that lines the mucous membranes lining the mouth, airways, and digestive tract. A deficiency in IgA is common in patients with bronchitis, conjunctivitis and otitis media.  Other Randox assays that may  be used  detect differing infections include: albumin, ferritin, alpha-1-antitrypsin (AAT), complement C3, complement C4, haptoglobin, CRP, alpha-1-acid glycoprotein (AGP) and anti-streptolysin (ASO).

RX series

The RX series range of Clinical Chemistry Analysers offer the most comprehensive testing profile for assessing inflammation and infection complications which identifies any potential infectious issues a patient may have. The world famed RX series test menu includes specific tests associated with inflammation and infection including Alpha-I Acid Glycoprotein, ASO, CRP, Lactate and Rheumatoid Factor tests.

The RX series zinc test will assess the levels of zinc in a patient sample, zinc plays a significant role in an individual’s health. It’s functions include cell and enzyme production as well as wound healing, therefore it is vitally important for a patient to be aware if they are either deficient or within the normal range for zinc and other infectious related tests to ensure potential infections can be prevented. To view the full RX series test menu click here.

 

 

 

Internal Quality Control

Randox has partnered up with Qnostics to provide a wide range of molecular controls for infectious disease testing. Designed to meet the demand of today’s molecular diagnostics laboratory and laboratories carrying out Nucleic Acid Testing (NAT), the Qnostics Molecular Infectious Disease range comprises hundreds of characterised viral, bacterial and fungal targets covering a wide range of Transplant Associated Diseases, Respiratory Infections, Blood Borne Viruses, Sexually Transmitted Infections, Gastrointestinal Diseases and Central Nervous System Diseases.

External Quality Assessment

Randox have also partnered up with QCMD to offer a vast array of molecular EQA programmes for infectious disease testing. With an extensive database of over 2000 participants in over 100 countries, QCMD is one of the largest providers of molecular EQA in the field of molecular diagnostics. Frequent challenges, comprehensive reports and international accreditation ensures the best assessment of test system performance.


Randox Biochip Array (BAT) Technology free from Biotin-Streptavidin

Biotin

Biotin, also known as vitamin B7, is involved with fatty acid metabolism, amino acid degradation, and gluconeogenesis.  The recommended daily intake for biotin is roughly 30-70µg, which is extremely low, meaning that biotin deficiency is rare.  Recently, there has been a surge in biotin supplementation mainly for beauty reasons, including: stronger nails and healthier skin and hair, resulting in the biotin craze on Instagram.  Currently 162K posts are attributed to the biotin hashtag (#biotin) on Instagram.  Whilst biotin supplementation is beneficial for numerous health conditions, including: multiple sclerosis (MS), diabetes, elevated cholesterol, and metabolic dysfunction, the increasing use of biotin by patients has created a problem with in vitro diagnostic testing.

With numerous manufacturers using biotin-streptavidin technology to develop in vitro diagnostic tests, combined with the rise in biotin supplementation use, the FDA (food and drug administration) issued an alert regarding the potential for erroneous results triggered by high levels of biotin in patient samples, at the end of 2017.  Clinical decisions based on these false results from biotin technology can lead to inaccurate diagnosis and inappropriate treatment prescribed.  The FDA confirmed that a patient, who was consuming high levels of biotin, died when a troponin tested was skewed and failed to show that the patient was having a heart attack.  Other tests that can produce erroneous results include: cardiac, pregnancy, cancer and iron-deficiency tests.

Biotin-Streptavidin

(Halasey, 2018)

The image above highlights that in biotin-free patient samples, the analyte to be tested successfully binds to the biotinylated antibody and the labelled antibody ultimately ensuring accurate measurement.  In the patient sample containing high levels of biotin, the biotin inhibits streptavidin’s ability to capture the analyte-antibody complex, generating falsely lowered results.

As 70% of all clinical decisions are based on results from in vitro diagnostic tests, it is vital that laboratories are selecting in vitro diagnostic tests that do not adopt the biotin-streptavidin technology to ensure accurate patient testing.

Randox do not utilise the biotin-streptavidin technology in the development of the Biochip Array Technology (BAT).

The Randox Biochip facilitates multiplex testing for faster, more comprehensive patient testing.  This technology, free from biotin-streptavidin, uses capture antibodies bound to a solid substrate (biochip surface) as opposed to biotinylated antibodies used by other manufacturers.  The Biochip also utilises enzyme labelled conjugate to enable chemiluminescent detection of the target in the patient sample.

Biochip test menu

The Biochip Array Technology (BAT) from Randox is capable of simultaneous multi-analyte diagnostic testing within the fields of clinical research and drugs of abuse testing.  The technology works through combining a panel of related assays on a single biochip with a single set of reagents, controls and calibrators.  An extensive range of Biochip panels are available, each optimised to provide the best performance.

Evidence

Evidence

The evidence analyser is the world’s first protein Biochip Array Technology system and has truly transformed laboratory diagnostics worldwide.  As the first of its kind, the Evidence has introduced higher standards of quality efficiency and reliability to numerous sectors including hospitals and clinical laboratories, forensic and clinical toxicology, pharmaceutical/CRO applications, as well as veterinary laboratories.

Evidence Evolution

Evolution

The world’s first fully automated random access Biochip testing platform.  The Evidence Evolution is set to revolutionise current diagnostic testing.  With the capability to process up to 2,640 tests per hour, the Evidence Evolution utilises multiplexing technology, offering advanced test consolidation, patient profiling, a complete system integration, as well as the most comprehensive test menu on the market.

Investigator

Investigator

The #1 choice for research, clinical, forensic, and veterinary testing.  Using the multiplexing technology, the semi-automated benchtop immunoanalyser Evidence Investigator is suitable for medium throughput laboratories.  In addition to the current test menu for this analyser, Randox have new tests in development.

Reference:

Halasey. S, 2018, “Inside Track: Biotin Gets a Safety Alert”. Available from URL: http://www.clpmag.com/2018/01/inside-track-biotin-gets-safety-alert/


Randox – Nutritional Status

Randox are dedicated to improving health worldwide, throughout the month of July we hope to highlight how the Randox clinical product range can assess an individual’s nutritional status both accurately and swiftly allowing the necessary steps to be taken in order to improve nutritional status. Nutritional status is influenced by diet, the levels of nutrients in the body and the body’s ability to maintain normal levels of metabolic integrity. Assessing nutritional status will generally indicate if an individual is eating the correct variety and quantity of nutrients. The Randox portfolio comprises a wide range of products to combat nutritional status issues including the RX series range of biochemistry analysers, diagnostic reagents such as zinc, copper & lipase and an extensive QC range catering for nutritional status testing in both liquid & lyophilised formats.

Nutritional Status: Reagents

Randox Reagents have the highest quality reagents on the market and a test menu comprising of over 113 assays. Unique to Randox is the copper and zinc assays that hold equal importance in the diagnosis of kidney and liver damage.

The Randox zinc assay can be used to measure levels of zinc in a patient’s urine providing insight into the levels of zinc in the body. The Randox copper assay is used to measure the levels of copper in the blood in order to determine copper toxicity. Combining these Randox assays can aid in identifying the cause of liver damage in a patient, leading to correct treatment and recovery.

Nutritional Status: RX series

The RX series range offers the most comprehensive testing profile for assessing nutritional status to identify any nutritional deficiencies or any other nutritional issues within an individual. The world famed RX series test menu possesses the most extensive nutritional status testing panel available to give an expansive picture of an individual’s nutritional status. The RX series zinc test can identify a zinc deficiency in an individual which is often a result of a low dietary intake and can lead to many problems including impaired immune & cognitive functions, kidney disease and diabetes. To view the full RX series test menu click here.

Nutritional Status: Quality Control

The Randox Acusera Liquid Chemistry Premium Plus control is designed for use in the routine monitoring of reproducibility and is the most comprehensive chemistry control available. As a true third party control it is suitable for use with all major instruments and covers over 100 parameters including routine chemistries, immunoassays, lipids, cardiac markers, proteins, therapeutic drugs and electrophoresis effective consolidation and significant cost savings are guaranteed.

Nutritional Status: RIQAS

The RIQAS General Clinical Chemistry EQA programme is designed to monitor the performance of up to 52 parameters covering routine chemistries, lipids, hormones and trace metals. Three flexible, cost effective programme options allow you to choose the correct challenge that is right for your lab. Bi-weekly, online reporting with reports returned within 72 hours allows corrective action to be taken sooner, avoiding dangerous misdiagnoses.

 


Improving Women’s Health With Randox

Randox are dedicated to improving health worldwide, Throughout the month of June we hope to highlight how the Randox clinical product range can ensure accurate and swift diagnosis and by doing so improving women’s health by allowing for the necessary steps to be taken post diagnoses. A common held misconception is that breast cancer is the biggest threat to a women’s health however the biggest health risk to a woman statistically is heart disease which accounts for roughly 27% of female death. The Randox clinical product range offers a wide range of products to combat heart issues including the RX series extensive cardiac testing panel, reagents such as H-FABP, Adiponectin an TxB Cardio and an extensive cardiac QC range available in both liquid & lyophilised format.

 

Women's Health: Reagents

Randox Reagents have the highest quality reagents on the market and a test menu comprising of over 118 assays covering over 100 disease markers. Several of these reagents will play a key role in diagnosis in woman such as Randox’s Lipoprotein (a) – Lp(a) test,   The Randox Lp(a) offers swift and accurate diagnosis of elevated circulation Lp(a) levels which is significant for woman as women have an increased risk of CVD due to elevated levels of Lp(a).  Several traditional CVD risk markers, including elevated LDL may be absent in some women, elevated Lp(a) levels may identify women at high risk of developing CVD.

Women's Health: RX series

The RX series range of clinical chemistry analysers offers the most comprehensive testing profile for assessing health in males and females. Urinary tract infections are more commonly found in women and the RX series extensive renal function panel will provide clarity  in terms of a woman’s urological health by testing for 19 separate analytes, including microalbumin. The RX series microalbumin test can detect very low levels of albumin in urine and if albumin is detected it can be an indicator of kidney injury and can result in irreversible damage. To view the full RX series test menu click here.

 

Women's Health: Quality Control

The Randox Acusera Maternal Screening quality control is the only commercially available control which covers all six analytes used during first and second trimester screening of Down’s syndrome and Spina Bifida. Instrument specific target values and ranges are provided for AFP, Inhibin A, PAPP-A, β hCG, Total hCG and Unconjugated Estriol. The inclusion of PAPP-A and Inhibin A eliminates the need to purchase additional controls at extra expense.

Women's Health: RIQAS

The RIQAS Maternal Screening EQA programme is designed to monitor the performance of screening tests used during the first and second trimester of pregnancy to assess the risk of Down’s syndrome, Spina Bifida and Trisomy 18. 100% human serum ensures commutability while the lyophilised material allows for enhanced stability. Monthly reporting allows laboratories to become aware of issues and remedy them early.


Neonatal Health With Randox

Neonatal screening is vital for the overall health of newborn babies. Although it is not a mandatory procedure it is highly recommended to detect infections and diseases that can have devastating consequences if not diagnosed soon after birth. Randox’s range of neonatal reagents include CRP, Bilirubin and Complement C4 that are essential in the detection of neonatal lupus and jaundice; which if left undetected can lead to sickle cell anaemia, rubella and even syphilis. Armed with these specific and high quality reagents and Randox Quality Control material ensures not only the early detection of such diseases but also the accuracy and reliability of the laboratory test results that can help to ensure that your baby gets the best start in life.

Neonatal Health: Reagents

Randox Reagents have the highest quality reagents on the market and a test menu comprising of over 118 assays covering over 100 disease markers. Our specific reagents for neonatal health include, G-6-PDH, IgEBilirubin, Copper, Complement C4 & C3IgA , CRP and CRP full range. With flexible pack sizes and a comprehensive list of analyser applications available, you are sure to find what you are looking for.

Neonatal Health: RX series

Randox has developed the RX series of clinical chemistry analysers for superior semi-automated and fully automated testing. The RX series extensive dedicated test menu goes beyond routine testing and has many unique and high-performance tests available. Our range of tests covers several parameters to assess neonatal health.

Neonatal Health: Quality Control

Randox Liquid Bilirubin Control provides a true third party solution for the measurement of bilirubin. Designed to deliver unbiased and independent results, it ensures your instrument is accurate and reliable when testing real patient samples. An elevated bilirubin control is also available to monitor accuracy at higher levels enabling early medical intervention when it matters.

Neonatal Health: RIQAS

RIQAS is the largest international external quality assessment scheme with 45,000 participants worldwide. With 33 comprehensive EQA programmes and world renowned consolidation, it reduces the number of individual programmes required. RIQAS programmes are available to compliment neonatal health tests.


NeoNatal

Metabolic health is a term used to describe a collection of  required chemical reactions that take place in all living organisms. A metabolic disorder develops when an abnormal chemical reaction occurs which alters the normal metabolic process.

Did you know?

 Approximately 20-25% of the world’s adult population have metabolic syndrome?

 

Randox has developed the RX series of clinical chemistry analysers for superior semi-automated and fully automated testing. The RX series extensive dedicated test menu goes beyond routine testing and has many unique and high-performance tests available. Our range of tests covers several parameters to assess your overall metabolic health.

Metabolic Health Profile

Albumin Chloride Potassium
Alkaline Phosphatase  C0Total Sodium
ALT Creatinine Total Bilirubin
AST (GOT) Glucose Total Protein
Direct Bilirubin Lactate Urea
Calcium

The RX series clinical chemistry analysers provide laboratories with a robust and smart solution ensuring you maintain a consistent workflow and can provide accurate results first time, every time. Offering excellent customer support services, our trained engineers are on hand to work with you in preserving the continuity of your operations while maximising the potential of your RX series instrument.Our world-famous test menu of high quality reagents ensures excellence in patient care, guaranteeing unrivalled precision and accuracy reducing costly test re-runs or misdiagnosis and offering complete confidence in results.

For more information visit: https://www.randox.com/clinical-chemistry-analysers/

Metabolic syndrome comprises of risk factors such as high blood pressure, high blood sugar/cholesterol and abdominal fat, which together, can lead to serious long term problems including an increased risk of heart disease, stroke and developing type 2 diabetes. Randox have developed an extensive range of reagents to accurately diagnose and monitor metabolic health, with the aim that patients can take the appropriate measurements to improve their health.

All reagents are available for use on a wide range of third party biochemistry analysers. Contact us to request an application for your specific analyser.

Adiponectin

Adiponectin is a clinical diagnostic biomarker for metabolic risk assessment. Adiponectin is solely excreted by adipocytes and is a protein hormone with anti-inflammatory and insulin-sensitising properties. It plays an important role in a number of metabolic processes such as glucose regulation and fatty acid oxidation. Levels of adiponectin have been linked with several pathologies including metabolic syndrome, cancer and cardiovascular disease, as levels are inversely correlated with Abdominal Visceral Fat (AVF). Randox is one of the only manufacturers of adiponectin in an automated biochemistry format, removing the inconvenience and time consumption associated with traditional ELISA-based testing.

For more information visit: https://www.randox.com/adiponectin/

Small-dense LDL (sLDL) Cholesterol

Small-dense LDL cholesterol is a vital cardiac risk marker, usually tested in patients with prediabetes or metabolic syndrome. Randox sLDL utilises the “Denka Seiken” method which produces results in less than ten minutes. Research has shown individuals with a predominance of sLDL have a 3-fold increased risk of myocardial infarction (MI), even for those who HDL, LDL, Total Cholesterol and Triglyceride levels are considered ‘normal’. Elevated levels of sLDL are associated with a sedentary lifestyle, a diet high in saturated fat, insulin resistance, pre-diabetes and genetic disposition. Measurement of sLDL allows the clinician to get a more comprehensive picture of lipid risk factors and tailor treatment accordingly. Reducing LDL levels reduce the risk of both CVD and MI.

For more information visit: www.randox.com/sldl-cholesterol/

TxBCardio™

Randox TxBCardio™ is used to assess the level of aspirin resistance in patients at risk of cardiovascular disease. Aspirin resistance is a serious clinical problem and is estimated to affect 25-20% of patients on a low dosage. It is important to assess aspirin resistance as this may be anticipated in patients with metabolic syndrome. The identification of these patients can be significantly improved through the use of Randox TxBCardio™ as the results generated can be used to enable timely intervention by clinicians and they can focus on anti-platelet therapy.

For more information visit: https://www.randox.com/txbcardio/

 

Other metabolic health tests:

  • Albumin
  • Alkaline Phosphatase
  • ALT
  • AST (GOT)
  • Direct Bilirubin
  • Calcium
  • Chloride
  • CO2 Total
  • Creatinine
  • Glucose
  • Lactate
  • Potassium
  • Sodium
  • Total Bilirubin
  • Total Protein
  • Urea

      When diagnosing and monitoring metabolic-related complications such as Diabetes and Cardiovascular Disease (CVD), it is vital that laboratories have a robust Quality Control (QC) system in place to ensure the accuracy and reliability of the results produced. As a world leading manufacturer of QC solutions including Third Party Controls and External Quality Assessment (EQA), our extensive product portfolio is designed to help reduce costs and time without compromising on quality.

      Diabetes

      Liquid HbA1c Control

      • Liquid ready-to-use format ideal for use in the lab or at the POC
      • Whole blood sample matrix commutable with that of the patient sample
      • Assayed control with values available for HPLC
      • Convenient bi-level pack accurately covering the patient reportable range
      • Open vial stability of 30 days ultimately helping to reduce waste and costs
      • For more information visit: https://www.randox.com/liquid-hba1c-quality-control/

      Glycated Hemoglobin EQA Programme

      • Monthly analysis ensuring early identification of test system errors
      • Maximised peer groups for comparative performance assessment
      • Reports available within 72 hours allowing corrective action to be taken immediately
      • User-friendly reports delivering at-a-glance performance assessment
      • For more information visit: https://www.randox.com/hba1c-eqa/

      CVD risk

      Lipid Control

      • Covers the complete lipid profile
      • True third party control ensuring unbiased performance assessment with any instrument or method
      • Manufactured from 100% human serum ensuring a matrix commutable with the patient sample
      • Free from Sodium Azide which can interfere with direct clearance methods of HDL and LDL Cholesterol
      • Three clinically significant levels available covering low, borderline and high risk levels of HDL and LDL Cholesterol
      • For more information visit: https://www.randox.com/lipid-quality-control/

      Lipid EQA Programme

      • Covers the complete lipid profile with a choice of reporting just three parameters at a reduced cost
      • Monthly analysis ensuring early identification of test system errors
      • Maximised peer groups for comparative performance assessment
      • Reports available within 72 hours allowing corrective action to be taken immediately
      • User-friendly reports delivering at-a-glance performance assessment
      • For more information visit: https://www.randox.com/lipids-eqa/

      Our Randox Health clinics offer comprehensive health testing as part of our Signature, Everyman and Everywoman packages to  give you a comprehensive picture of your overall metabolic health. Our clinics utilise the same cutting-edge tests and quality control that we have available to clinical laboratories globally, as well as our patented Biochip Array Technology (BAT).

      For more information visit: https://www.randoxhealth.com/

      A common misconception surrounding metabolic health is that it refers solely to your weight, and if you are overweight you are considered to be unhealthy. But in actual fact this may not be entirely true. Good metabolism means that your body is in good overall health, which doesn’t account for just your weight! Common metabolic disorders include genetic metabolic disorders, diabetes and metabolic syndrome. Understanding and testing to see how well your metabolism is functioning is key to ensuring long lasting health.

      Genetics

      There are a number of genetic metabolic disorders caused by mutations of single genes. Examples of common disorders include Gaucher’s disease, hemochromatosis and cystic fibrosis. Gaucher’s disease is a genetic disorder that affects the body’s ability to break down fat that can accumulate in the liver/spleen and bone marrow. Hemochromatosis is a condition that is caused by the over-absorption and build-up of iron while cystic fibrosis is a metabolic disorder that appears as a result of a build-up of mucus in lungs/liver and intestines. Each of these metabolic disorders affect certain organs from functioning properly and therefore your overall healthiness.

      Diabetes

      Type 2 diabetes is one of the most common types of  metabolic disorders in the world that is expected to affect 592 million people by 2035. It is characterised by high blood sugar, insulin resistance or a lack of insulin being produced by the pancreas. Insulin resistance occurs when the body isn’t able to use insulin the right way which increases blood glucose levels. Insulin is needed for cells to take in glucose (sugar) from the bloodstream and convert it into energy. Over time this lack of insulin can damage the organs in your body.

      Metabolic Syndrome

      Metabolic syndrome (also known as syndrome X, Reaven’s syndrome, and CHAOS) is not a disease but a collection of risk factors that affect your health; these include high blood pressure, high blood sugar/cholesterol and abdominal fat. Left untreated, these risk factors, together, can lead to long term serious problems including an increased risk of heart disease, stroke and developing type 2 diabetes.

      Can you improve your metabolic health?

      Yes! The good news is that if you discover that your metabolic health is not up to scratch you can improve it through a combination of diet, exercise and lifestyle adjustments such as:

      • 30 minutes of moderate to intense exercise 5-7 times a week
      • Low-dose aspirin to reduce your risk of stroke or heart attack
      • Quit smoking
      • Medication for blood pressure/cholesterol/ blood sugar
      • Limit alcohol intake
      • Eat a healthy balanced diet

      Related Products 

      follow us on social media


      Metabolic Health

      Metabolic health is a term used to describe a collection of  required chemical reactions that take place in all living organisms. A metabolic disorder develops when an abnormal chemical reaction occurs which alters the normal metabolic process.

       

      Did you know?

       Approximately 20-25% of the world’s adult population have metabolic syndrome?

       

      A common misconception surrounding metabolic health is that it refers solely to your weight, and if you are overweight you are considered to be unhealthy. But in actual fact this may not be entirely true. Good metabolism means that your body is in good overall health, which doesn’t account for just your weight! Common metabolic disorders include genetic metabolic disorders, diabetes and metabolic syndrome. Understanding and testing to see how well your metabolism is functioning is key to ensuring long lasting health.

      Genetics

      There are a number of genetic metabolic disorders caused by mutations of single genes. Examples of common disorders include Gaucher’s disease, hemochromatosis and cystic fibrosis. Gaucher’s disease is a genetic disorder that affects the body’s ability to break down fat that can accumulate in the liver/spleen and bone marrow. Hemochromatosis is a condition that is caused by the over-absorption and build-up of iron while cystic fibrosis is a metabolic disorder that appears as a result of a build-up of mucus in lungs/liver and intestines. Each of these metabolic disorders affect certain organs from functioning properly and therefore your overall healthiness.

      Diabetes

      Type 2 diabetes is one of the most common types of  metabolic disorders in the world that is expected to affect 592 million people by 2035. It is characterised by high blood sugar, insulin resistance or a lack of insulin being produced by the pancreas. Insulin resistance occurs when the body isn’t able to use insulin the right way which increases blood glucose levels. Insulin is needed for cells to take in glucose (sugar) from the bloodstream and convert it into energy. Over time this lack of insulin can damage the organs in your body.

      Metabolic Syndrome

      Metabolic syndrome (also known as syndrome X, Reaven’s syndrome, and CHAOS) is not a disease but a collection of risk factors that affect your health; these include high blood pressure, high blood sugar/cholesterol and abdominal fat. Left untreated, these risk factors, together, can lead to long term serious problems including an increased risk of heart disease, stroke and developing type 2 diabetes.

      Can you improve your metabolic health?

      Yes! The good news is that if you discover that your metabolic health is not up to scratch you can improve it through a combination of diet, exercise and lifestyle adjustments such as:

      • 30 minutes of moderate to intense exercise 5-7 times a week
      • Low-dose aspirin to reduce your risk of stroke or heart attack
      • Quit smoking
      • Medication for blood pressure/cholesterol/ blood sugar
      • Limit alcohol intake
      • Eat a healthy balanced diet

      Related Products 

      Randox has developed the RX series of clinical chemistry analysers for superior semi-automated and fully automated testing. The RX series extensive dedicated test menu goes beyond routine testing and has many unique and high-performance tests available. Our range of tests covers several parameters to assess your overall metabolic health.

      Metabolic Health Profile

      Albumin Chloride Potassium
      Alkaline Phosphatase  C0Total Sodium
      ALT Creatinine Total Bilirubin
      AST (GOT) Glucose Total Protein
      Direct Bilirubin Lactate Urea
      Calcium

      The RX series clinical chemistry analysers provide laboratories with a robust and smart solution ensuring you maintain a consistent workflow and can provide accurate results first time, every time. Offering excellent customer support services, our trained engineers are on hand to work with you in preserving the continuity of your operations while maximising the potential of your RX series instrument.Our world-famous test menu of high quality reagents ensures excellence in patient care, guaranteeing unrivalled precision and accuracy reducing costly test re-runs or misdiagnosis and offering complete confidence in results.

      For more information visit: https://www.randox.com/clinical-chemistry-analysers/

      Metabolic syndrome comprises of risk factors such as high blood pressure, high blood sugar/cholesterol and abdominal fat, which together, can lead to serious long term problems including an increased risk of heart disease, stroke and developing type 2 diabetes. Randox have developed an extensive range of reagents to accurately diagnose and monitor metabolic health, with the aim that patients can take the appropriate measurements to improve their health.

      All reagents are available for use on a wide range of third party biochemistry analysers. Contact us to request an application for your specific analyser.

      Adiponectin

      Adiponectin is a clinical diagnostic biomarker for metabolic risk assessment. Adiponectin is solely excreted by adipocytes and is a protein hormone with anti-inflammatory and insulin-sensitising properties. It plays an important role in a number of metabolic processes such as glucose regulation and fatty acid oxidation. Levels of adiponectin have been linked with several pathologies including metabolic syndrome, cancer and cardiovascular disease, as levels are inversely correlated with Abdominal Visceral Fat (AVF). Randox is one of the only manufacturers of adiponectin in an automated biochemistry format, removing the inconvenience and time consumption associated with traditional ELISA-based testing.

      For more information visit: https://www.randox.com/adiponectin/

      Small-dense LDL (sLDL) Cholesterol

      Small-dense LDL cholesterol is a vital cardiac risk marker, usually tested in patients with prediabetes or metabolic syndrome. Randox sLDL utilises the “Denka Seiken” method which produces results in less than ten minutes. Research has shown individuals with a predominance of sLDL have a 3-fold increased risk of myocardial infarction (MI), even for those who HDL, LDL, Total Cholesterol and Triglyceride levels are considered ‘normal’. Elevated levels of sLDL are associated with a sedentary lifestyle, a diet high in saturated fat, insulin resistance, pre-diabetes and genetic disposition. Measurement of sLDL allows the clinician to get a more comprehensive picture of lipid risk factors and tailor treatment accordingly. Reducing LDL levels reduce the risk of both CVD and MI.

      For more information visit: www.randox.com/sldl-cholesterol/

      TxBCardio™

      Randox TxBCardio™ is used to assess the level of aspirin resistance in patients at risk of cardiovascular disease. Aspirin resistance is a serious clinical problem and is estimated to affect 25-20% of patients on a low dosage. It is important to assess aspirin resistance as this may be anticipated in patients with metabolic syndrome. The identification of these patients can be significantly improved through the use of Randox TxBCardio™ as the results generated can be used to enable timely intervention by clinicians and they can focus on anti-platelet therapy.

      For more information visit: https://www.randox.com/txbcardio/

       

      Other metabolic health tests:

      • Albumin
      • Alkaline Phosphatase
      • ALT
      • AST (GOT)
      • Direct Bilirubin
      • Calcium
      • Chloride
      • CO2 Total
      • Creatinine
      • Glucose
      • Lactate
      • Potassium
      • Sodium
      • Total Bilirubin
      • Total Protein
      • Urea

          When diagnosing and monitoring metabolic-related complications such as Diabetes and Cardiovascular Disease (CVD), it is vital that laboratories have a robust Quality Control (QC) system in place to ensure the accuracy and reliability of the results produced. As a world leading manufacturer of QC solutions including Third Party Controls and External Quality Assessment (EQA), our extensive product portfolio is designed to help reduce costs and time without compromising on quality.

          Diabetes

          Liquid HbA1c Control

          • Liquid ready-to-use format ideal for use in the lab or at the POC
          • Whole blood sample matrix commutable with that of the patient sample
          • Assayed control with values available for HPLC
          • Convenient bi-level pack accurately covering the patient reportable range
          • Open vial stability of 30 days ultimately helping to reduce waste and costs
          • For more information visit: https://www.randox.com/liquid-hba1c-quality-control/

          Glycated Hemoglobin EQA Programme

          • Monthly analysis ensuring early identification of test system errors
          • Maximised peer groups for comparative performance assessment
          • Reports available within 72 hours allowing corrective action to be taken immediately
          • User-friendly reports delivering at-a-glance performance assessment
          • For more information visit: https://www.randox.com/hba1c-eqa/

          CVD risk

          Lipid Control

          • Covers the complete lipid profile
          • True third party control ensuring unbiased performance assessment with any instrument or method
          • Manufactured from 100% human serum ensuring a matrix commutable with the patient sample
          • Free from Sodium Azide which can interfere with direct clearance methods of HDL and LDL Cholesterol
          • Three clinically significant levels available covering low, borderline and high risk levels of HDL and LDL Cholesterol
          • For more information visit: https://www.randox.com/lipid-quality-control/

          Lipid EQA Programme

          • Covers the complete lipid profile with a choice of reporting just three parameters at a reduced cost
          • Monthly analysis ensuring early identification of test system errors
          • Maximised peer groups for comparative performance assessment
          • Reports available within 72 hours allowing corrective action to be taken immediately
          • User-friendly reports delivering at-a-glance performance assessment
          • For more information visit: https://www.randox.com/lipids-eqa/

          Our Randox Health clinics offer comprehensive health testing as part of our Signature, Everyman and Everywoman packages to  give you a comprehensive picture of your overall metabolic health. Our clinics utilise the same cutting-edge tests and quality control that we have available to clinical laboratories globally, as well as our patented Biochip Array Technology (BAT).

          For more information visit: https://www.randoxhealth.com/

          follow us on social media


          Renal Function and Health

          Renal Health

          Your kidneys are vital for survival, they filter waste substances out of your blood and balance the levels of salts and water in our bodies. Your kidneys filter around 180 litres of blood every day, control the production of red blood cells and release hormones that regulate blood pressure – it’s little wonder, then, the importance placed on looking after such a vital organ.

          Did you know?

          Around 1 in 8 people in the UK will develop Chronic Kidney Disease (CKD)

          Kidney Disease can affect people of all ages and races, 10% of the population worldwide is affected by Chronic Kidney Disease (CKD.) Since Kidney Disease can sneak up without symptoms it has been labelled a silent killer, a person can lose up to 90% of their kidney function before experiencing any signs or symptoms.

          As kidney disease gets worse, wastes can build up in your blood and make you feel sick. You may develop additional problems such as high blood pressure, anemia, weak bones, poor nutritional health and nerve damage. Kidney disease also increases your risk of developing heart or blood vessel disease. These problems often develop slowly and will often lead to kidney failure.

          The two main causes of CKD are diabetes and high blood pressure, which are responsible for up to two-thirds of cases, other causes include inherited kidney diseases and malformations at birth.

           

          How is Chronic Kidney Disease detected?

          Early detection and treatment is crucial to keep kidney disease from developing into kidney failure, some simple tests can be carried out to detect early kidney disease. These are;

          1. A urine test to check if there is any protein present
          2. A blood test to measure levels of creatinine

          The best treatment is early detection when CKD can be slowed or stopped, however once kidneys fail, treatment with dialysis or a kidney transplant is needed. 8 of 10 people on the transplant list are waiting for a kidney, the average wait for a new kidney is 3 years, and every day one kidney patient will die waiting for a transplant.

           

          Reduce your risk of developing CKD

          Your kidneys are vital to your overall health, so it’s important to look after them. There are 5 simple steps that can help you keep them in good shape;

          1. Stay hydrated
          2. Maintain a balanced diet and keep your weight in check
          3. Monitor your blood pressure
          4. Quit Smoking
          5. Limit your alcohol intake

          Related Products 

          Randox has developed the RX series of clinical chemistry analysers for superior semi-automated and fully automated testing. The RX series extensive dedicated test menu goes beyond routine testing and has many unique and high-performance tests available. Our range of tests covers several parameters to assess renal health.

          Renal Function

          Albumin Creatinine Enzymatic IgG Phosphorus (Inorganic)
          Ammonia Creatinine (Jaffe) LDH Urinary Protein
          Beta-2 Microglobulin Cystatin C Magnesium Urea
          Calcium Glucose Potassium Uric Acid
          Chloride HbA1c/Hb Sodium

          Our world-famous test menu of high quality reagents ensures excellence in patient care, guaranteeing unrivalled precision and accuracy reducing costly test re-runs or misdiagnosis and offering complete confidence in results.

          The RX series clinical chemistry analysers provide laboratories with a robust and smart solution ensuring you maintain a consistent workflow and can provide accurate results first time, every time. Offering excellent customer support services, our trained engineers are on hand to work with you in preserving the continuity of your operations while maximising the potential of your RX series instrument.

          For more information visit: https://www.randox.com/clinical-chemistry-analysers/

           

           

          Kidney disorders can develop and advance overtime without any signs and the symptoms are not recognised as being associated with renal impairment. Kidney health and regular renal screening is important to enable renal impairment to be detected in its earliest stages to prevent renal failure.  Randox offers a comprehensive range of high performance reagents for the detection and characterisation of renal function problems.

          All reagents are available for use on a wide range of third party biochemistry analysers. Contact us to request an application for your specific analyser.

          Cystatin C

          Cystatin C is a useful marker where creatinine measurements are unsuitable e.g. patients who are obese, malnourished, have liver cirrhosis or reduced muscle mass.  Cystatin C also does not have a ‘blind area’ unlike creatinine – up to 50% of renal function can be lost before sufficient creatinine levels are detectable.  Cystatin C is extremely sensitive to small changes in Glomerular Filtration Rate (GFR) and so is capable of detecting early stages of renal impairment.

          For more information on Cystatin C, visit: www.randox.com/cystatin-c

          Enzymatic Creatinine

          Creatinine clearance in the kidneys gives a measurement of the GFR which is the standard marker for renal function.  The enzymatic method offers superior specificity when compared to the traditional Jaffe method.  Other benefits of the enzymatic method over the Jaffe method includes: limited interferences from bilirubin, haemoglobin, Intralipid® and Triglycerides making the assay more suitable for neonatal samples, eliminates the need for urea determination, highly specific and does not overestimate serum creatinine.

          For more information on Enzymatic Creatinine, visit: www.randox.com/creatinine

          Microalbumin

          The detection of albumin in urine can be an indicator of kidney injury, as damage to the glomerular basement membrane results in albumin seeping out of the kidneys into urine. Sustained elevations of urinary albumin concentrations are called Microalbuminuria. The Randox Microalbumin test is an excellent marker of kidney disease and can identify individuals with diabetic nephropathy approximately 5-10 years earlier than proteinuria tests reducing the incidence of end stage renal disease.   The American Diabetes Association and Diabetes UK recommend that all diabetics are screened for microalbuminuria on a yearly basis.

          For more information on Microalbumin, visit: www.randox.com/microalbumin

          Renal Testing Panel

          • Cystatin C
          • Creatinine Enzymatic
          • Creatinine Jaffe
          • Microalbumin
          • Total Urinary Protein
          • Urea
          • Sodium
          • Potassium
          • Albumin
          • Ammonia
          • β₂ Microglobulin
          • Calcium
          • Chloride
          • Glucose
          • HbA1c
          • IgG
          • LDH
          • Magnesium
          • Phosphorus (Inorganic)
          • Uric Acid

          When diagnosing and monitoring Chronic Kidney Disease (CKD), it is vital that laboratories have a robust Quality Control (QC) system in place to ensure the accuracy and reliability of the results produced. The Acusera Chemistry and Urine Controls have been designed to cover a wide range of kidney function tests at clinical decision levels eliminating the need for additional low level controls at extra expense.

          Our range of Chemistry Controls contain up to 100 analytes and cover a wide range of kidney function tests. Available in a choice of liquid or lyophilised formats, options are available to suit all laboratory sizes and budgets.

          Our portfolio of Urine Controls cover the full range of clinical testing, manufactured from 100% human serum a matrix similar to that of the patient is guaranteed. They are available in both liquid ready-to-use and lyophilised formats, making them ideal for use at the point-of-care and in the laboratory.

          Common kidney function parameters we cover include;

          • Albumin
          • Urea/BUN
          • Bicarbonate
          • Calcium
          • Chloride
          • Creatinine
          • Creatinine Clearance
          • Cystatin C
          • Glucose
          • Phosphate
          • Potassium
          • Sodium
          • Urine Albumin
          • Albumin/Creatinine Ratio
          • Beta-2 Microglobulin
          • Urinalysis
          • Urine Protein

          For more information, contact us at acusera@randox.com

          We also have corresponding RIQAS Chemistry and Urine Programmes which cover the common kidney function tests, including;

          RIQAS General Clinical Chemistry Programme

          The RIQAS General Clinical Chemistry EQA programme is designed to monitor the performance of up to 52 parameters. Three flexible yet cost effective programme options are available.

          • Accredited to ISO/IEC 17043
          • Lyophilised for enhanced stability
          • Human based serum
          • Bi-weekly reporting
          • Submit results and view reports online via RIQAS.Net
          • Register up to five instruments at no extra cost
          • Reference method values are provided for selected parameters/lots

          For more information, visit our RIQAS General Clinical Chemistry Programme page.

          RIQAS Human Urine Programme

          The RIQAS Human Urine EQA programme is designed to monitor the performance of up to 25 routine chemistry assays in urine.

          • Accredited to ISO/IEC 17043
          • Lyophilised for enhanced stability
          • 100% human urine
          • Bi-weekly reporting
          • Submit results and view reports online via RIQAS.Net
          • Register up to five instruments at no extra cost

          For more information, visit our RIQAS Human Urine Programme page

           

          Our Randox Health clinics offer comprehensive health testing as part of our Signature, Everyman and Everywoman packages to identify and assess risk of developing Kidney Disease. Our clinics utilise the same cutting-edge tests and quality control that we have available to clinical laboratories globally, as well as our patented Biochip Array Technology (BAT).

          For more information visit: https://www.randoxhealth.com/

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          Cardiac Risk

          CVD

          Your heart is amazing. Not only is it your most critical organ but also one of the most hard-working. The average adult heart beats around 100,000 times a day, acting as a giant pump for all the blood in your body. Indeed, every day your heart pumps over nine litres of blood through a system of blood vessels over 60,000 miles long – it’s little wonder, then, the importance placed on looking after such a vital muscle.

          Did you know?

          Cardiovascular Diseases (CVDs) are the number 1 cause of death globally, more people die annually from CVDs than any other cause.

           

          Over time, and influenced by lifestyle choices, the heart grows weaker, needing to work harder to fulfil its function. Crucial lifestyle changes now could limit your risk of developing serious cardiac conditions, such as Cardiovascular Disease (CVD) in the future.

          While lifestyle changes may help to limit your risk of CVD, and related heart condition, it is impossible to eradicate it completely for everyone. Cardiovascular disease is the number one cause of death globally. Across the world, 17.7 million people died from CVDs in 2015. In the UK, it accounts for nearly one death around every eight minutes.

          But early screening and improved access to cutting-edge diagnostics could lower this figure significantly. According to the WHO there are 8 key risk factors of developing CVD and they account for as much as 61% of all cardiovascular deaths, these include;

          Smoking

          The harmful substances in tobacco can damage and narrow blood vessels, causing CVDs. Smoking kills approximately half of persistent smokers, around 14% of deaths from circulatory disease can be attributed to smoking.

          High Blood Pressure

          High blood pressure (hypertension) is one of the most important risk factors of CVD, if your blood pressure is too high your blood vessels can become damaged.

          High BMI

          Being overweight or obese increases the risk of developing diabetes and high blood pressure, both of which can cause CVD. You’re at an increased risk of CVD if your BMI is 25 or above.

          High Cholesterol

          Cholesterol is a fatty substance found in the blood, high levels of cholesterol can cause blood vessels to narrow and increase the risk of developing a blood clot. Reducing the populations LDL-Cholesterol by 5% would prevent 64,000 cases of CVD.

          Lack of Physical Activity

          If you don’t exercise regularly, it’s more likely you’ll develop high blood pressure, high cholesterol levels and become overweight. All of which are risk factors of CVD. Exercising regularly helps to keep the heart healthy.

          Other CVD risk factors include an excessive alcohol intake, an unhealthy diet and high levels of blood glucose.

          Related Products 

          Randox has developed the RX series of clinical chemistry analysers for superior semi-automated and fully automated testing. The RX series extensive dedicated test menu goes beyond routine testing and has many unique and high-performance tests available. Our range of tests covers many tests for the diagnosis and monitoring of cardiac diseases.

          Cardiac Panel

          Cholesterol CRP Full Range(0.3-160mg/l) Direct LDL Cholesterol sLDL
          CK-MB CRP High Sensitivity Heart-Type Fatty Acid Binding Protein (H-FABP) Triglycerides
          CK-NAC Digoxin Lipoprotein(a) TxB Cardio
          CRP Direct HDL Cholesterol Myoglobin Adiponectin

           

          Our world leading test menu of high quality reagents guarantees excellence in patient care ensuring unrivalled precision and accuracy reducing costly test re-runs or misdiagnosis and offering complete confidence in results.

          The RX series clinical chemistry analysers provide laboratories with a robust and smart solution ensuring you maintain a consistent workflow and can provide accurate results first time, every time. Offering excellent customer support services, our trained engineers are on hand to work with you in preserving the continuity of your operations while maximising the potential of your RX series instrument.

          For more information visit: https://www.randox.com/clinical-chemistry-analysers/

          Cardiac health and regular cardiovascular screening is important to enable risk factors to be detected in their earliest stages. Randox reagents offer a comprehensive cardiology product profile which includes high performance reagents for the detection of conventional risk factors, as well as emerging biomarkers associated with further risk.

          sLDL cholesterol

          sLDL cholesterol  is a vital cardiac risk marker which utilises the “Denka Seiken” method which produces results in less than ten minutes. Research has shown individuals with a predominance of sLDL have a 3-fold increased risk of myocardial infarction (MI), even for those who HDL, LDL, Total Cholesterol and Triglyceride levels are considered ‘normal’. Elevated levels of sLDL are associated with a sedentary lifestyle, a diet high in saturated fat, insulin resistance, pre-diabetes and genetic disposition. Measurement of sLDL allows the clinician to get a more comprehensive picture of lipid risk factors and tailor treatment accordingly. Reducing LDL levels reduce the risk of both CVD and MI.

          For more information visit: www.randox.com/sldl-cholesterol/

          Lipoprotein (a)

          Lipoprotein (a) is a major independent genetic risk factor for premature CVD and elevated levels can occur in patients with otherwise normal lipid levels, therefore providing much needed information in relation to a patient’s risk of developing CVD.Along with other tests, Lp(a) can provide additional information on a patient’s risk factor of developing cardiovascular disease (CVD).

          The Randox Lp(a) assay is one of the only methodologies on the market that detects the non-variable part of the Lp(a) molecule and therefore suffers minimal size related bias providing more accurate and consistent results.

          For more information visit: www.randox.com/lipoprotein-a/

          Adiponectin

          Randox Adiponectin is a liquid ready-to-use automated biochemistry reagents offering a new and exciting technique for adiponectin measurement, which moves away from often time-consuming ELISA products. Adiponectin is solely excreted by adipocytes and is a protein hormone with anti-inflammatory and insulin sensitising properties. It plays an important role in a number of metabolic processes such as glucose regulation and fatty acid oxidation.

          Adiponectin levels are inversely correlated with abdominal visceral fat (AVF) levels, which have proven to be a strong predictor of several pathologies including cardiovascular disease, type 2 diabetes, metabolic syndrome and cancer.

          For more information visit: www.randox.com/adiponectin/

          HDL3 Cholesterol

          HDL3 Cholesterol is a smaller and more dense sub fraction of the HDL particle. HDL comprises of several subclass particles, which differ in their sizes, densities and components. HDL is the scavenger of cholesterol within arterial walls and the levels of HDL3 is too low, the ability to remove this cholesterol is reduced. Therefore, it is widely accepted that there is an inverse correlation between HDL3 and cardiovascular disease risk.

          For more information visit: https://www.randox.com/hdl3/

           

          Cardiology and Lipid Testing Panel

          • Adiponectin
          • Apolipoprotein A-I
          • Apolipoprotein A-II
          • Apolipoprotein B
          • Apolipoprotein C-II
          • Apolipoprotein C-III
          • Apolipoprotein E
          • Cholesterol (sLDL)
          • Cholesterol (HDL)
          • Cholesterol (LDL)
          • Cholesterol (Total)
          • Cholesterol (HDL3)
          • Lipoprotein (a)
          • High sensitivity CRP
          • Homocysteine
          • Triglycerides
          • HDL3-C
          • sPLA₂-IIA
          • Heart Type Fatty Acid Binding Protein (H-FABP)
          • CK-MB
          • Myoglobin
          • Digoxin
          • TxBCardio™

          Browse our full cardiology and lipid testing panel here.

          To request an application for your specific analyser, contact us at reagents@randox.com

          When diagnosing and monitoring CVD, it is vital that laboratories have a robust Quality Control (QC) system in place to ensure the accuracy and reliability of the results produced. The Acusera Cardiac Controls have been designed to cover a wide range of cardiac markers at clinical decision levels eliminating the need for additional low level controls at extra expense. Available in both liquid ready-to-use and lyophilised formats, they are ideal for use at the point-of-care and in the laboratory. Manufactured from 100% human serum a matrix similar to that of the patient is guaranteed.

          Liquid Cardiac Control

          • Liquid ready-to-use
          • 100% human serum
          • Assayed target values provided for 8 cardiac markers
          • Cut off levels for Troponin I and T in line with internationally recommended levels
          • Stable to expiry date at 2°C – 8°C
          • Open vial stability of 30 days at 2°C – 8°C for all analytes

          Analytes

          Myoglobin Troponin I Troponin T
          NT – ProBNP CK-MB (Mass) D-dimer
          Digoxin hsCRP

          Find out more about our Liquid Cardiac Quality Control here.

          Other cardiac quality controls include:

          For more information, visit our Cardiac Quality Controls page.

          RIQAS Cardiac Programme

          The RIQAS Cardiac EQA programme is designed to monitor the performance of up to 7 clinically significant cardiac markers. Two flexible reporting options are available to suit the needs of all laboratory sizes.

          • Accredited to ISO/IEC 17043
          • Lyophilised for enhanced stability
          • 100% human serum
          • Bi-weekly reporting
          • Submit results and view reports online via RIQAS.Net
          • Register up to five instruments at no extra cost

          For more information, visit our RIQAS Cardiac Programme page.

          Our Randox Health clinics offer comprehensive health testing as part of our Signature, Everyman and Everywoman packages to identify and assess risk of developing Cardiovascular Disease. Our clinics utilise the same cutting-edge tests and quality control that we have available to clinical laboratories globally, as well as our patented Biochip Array Technology (BAT).

          For more information visit: https://www.randoxhealth.com/

          follow us on social media


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