Key benefits of the Randox sTfR reagent
The Randox sTfR assay showed a correlation coefficient of r=0.977 when compared against other commercially available methods
Excellent measuring range
The healthy range for sTfR is 0.65 – 1.88mg/L. The Randox sTfR assay can comfortably detect levels outside of the healthy range, measuring between 0.5 – 11.77mg/L
Latex Enhance Immunoturbidimetric method
Facilitating testing on biochemistry analysers and eliminating the need for dedicated equipment
Other features of the Randox sTfR reagent
- Latex enhanced immunoturbidimetric method
- Liquid ready-to-use reagents for convenience and ease-of-use
- Stable to expiry date when stored at +2 to +8 °C
- Excellent measuring range of 0.5 – 11.77mg/L
- Excellent correlation coefficient of r=0.977
About the Soluble Transferrin Receptor (sTfR) assay
Biological significance of sTfR
Transferrin transports iron around the body, donating it to bodily cells by interacting with a specific membrane receptor, the transferrin receptor (TfR). The soluble transferrin receptor (sTfR) is a truncated form (shorten) 0f the transferrin receptor, formed as a result of proteolysis (the breakdown of proteins into smaller polypeptides or amino acids). A soluble form of the TfR has been identified in animal and human serum, circulating freely in the blood. The serum concentration of sTfR is directly proportional to the concentration of the membrane bound transferrin receptors.
Clinical significance of sTfR
Soluble transferrin receptor is a marker of iron status. In iron deficiency anaemia, soluble transferrin receptor levels are significantly increased, however, remain normal in acute phase conditions including: chronic diseases and inflammation. As such, soluble transferrin receptor measurements are useful in the differential diagnosis of anaemia: anaemia of chronic disease (ACD) or iron deficiency anaemia (IDA).
In IDA, increased soluble transferrin receptor levels have been observed in haemolytic anaemia, sickle cell anaemia, B12 deficiency and functional iron deficiency in pregnancy.
In ACD, soluble transferrin receptor levels do not correlate with iron status. This was observed in patients with chronic illnesses (cystic fibrosis and cancer), certain infections, autoimmune diseases (insulin-dependent diabetics) and inflammatory diseases. For more information on ACD, please click here [external link].
Specific Proteins Panel
For more information or to view more reagents within the veterinary panel, please click here.