Emerging SARS-CoV-2 variants: successful detection despite virus mutation

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Emerging SARS-CoV-2 variants: successful detection despite virus mutation

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02 February 2021

Test performance not affected by mutation found in new UK, South African and Brazilian variants.

The new SARS-CoV-2 variants that have been identified recently in the UK (known as 501Y.V1, VOC202012/01 or B.1.1.7 lineage), South Africa (known as 501Y.V2 or B.1.351 lineage) and Brazil (B.1.1.248 lineage), contain multiple mutations in the segment of the virus’ genome that codes for the spike protein.

Of particular interest is a double deletion at position 69-70 of the spike protein gene (69-70del), observed in the B1.1.7 variant, which has been found to affect the performance of some diagnostic PCR assays that use an S gene target (S gene dropout).

Detection of SARS-CoV-2 using the multiplex RT-qPCR assay from Randox Laboratories Ltd. is not affected by the identified mutations. This kit is a fast and highly sensitive multiplex diagnostic solution containing the necessary components to provide the detection of two genes (ORf I ab, E gene) to reduce the impact of genetic variation in the SARS-CoV-2 genome. The multiplex primer mix in this assay allows the amplification of specific gene sequences found within the genome of the pathogen, covering all variants. Therefore, the mutations in the B.I.I.7, B.I.351 and B.I.I.248 lineage variants do not affect the detection of SARS-CoV-2 by the PCR test.

Randox Laboratories Ltd. monitors SARS-CoV-2 variants in NCBI and GISAID databases and performs bioinformatics analysis regularly. Based on in silico analysis the performance of the test is not impacted by the mutations.

The Randox multiplex RT-qPCR diagnostic kit supports clinical and public health laboratories to quickly diagnose COVID-19 caused by SARS-CoV-2 infection, assisting the screening and isolation of individuals that require quarantine and immediate intervention.

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Randox launches new COVID-19 testing facility at Heathrow Airport

Randox launches new COVID-19 testing facility at Heathrow Airport

27 January 2021: Randox launches new COVID-19 testing facility at Heathrow Airport

Global healthcare diagnostics company Randox Health has announced a new COVID-19 testing facility at Heathrow Airport.

The service from Randox, which is the largest COVID-19 testing provider in the UK and Ireland, and a partner in the UK Government’s National COVID-19 Testing Programme, uses gold standard PCR technology to generate results in 1 – 3 hours.

The laboratory is capable of processing up to 1000 samples per day, for both fit to fly and test to release, which allows individuals in England returning home from international travel to stop self-isolating if they get a negative test result after 5 days.

Dr Peter FitzGerald, Randox Founder and Managing Director commented;

“We continue to expand our portfolio of bespoke testing products and services, and our new testing facility at Heathrow Airport brings us one step closer to a timely return to a more normal society.

“It’s great to be able to provide our fit to fly and test to release services to the airport and help support their enormous efforts to restore public confidence in international travel and get people back in the air again.”

The Randox testing facility at Heathrow Airport runs in partnership with Doctap who provide a team of certified Sample Collection Officers to perform the swabbing on site.

A Laboratory Technician subsequently expedites the sample and reports the results, meaning that a fit to fly or test to release certificate that would normally take up to 48 hours now takes as little as 1 hour, and no longer than 3 hours to deliver a certificate back to a customer.

To book a test please visit Doctap.co.uk/randox

For further information on the Mobile Testing Laboratory please email mobiletesting@randox.com

 

Randox Health offers a range of COVID-19 testing services for fit to fly, test to release, workplace testing or simply for peace of mind.

Order a home sample collection kit, book an appointment at a Randox Health Travel Centre (available in the UK and Ireland) or visit a Randox Mobile Laboratory (located at Heathrow and Liverpool Airports).

COVID-19 antibody testing is available in Randox Health Clinics.

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Randox approved for COVID-19 test to release scheme

RANDOX approved for COVID-19 test to release

21 December 2020: RANDOX approved for COVID-19 test to release

Randox has been added to the Department of Health and Social Care’s list of private providers of coronavirus testing.

This includes the lists for both general testing and test to release, a scheme which is applicable to those in England who need to self-isolate on their return from international travel.

If after 5 days you take a test and receive a negative result, you can stop self-isolating.

To purchase your COVID-19 test kit for test to release, visit; https://www.randoxhealth.com/covid-19-home-testing-kit-2/

Please Note: The earliest you can take the test is 5 full days after you left the country not on the travel corridor list. Individuals who do not opt into the Test to Release scheme will need to self-isolate until 10 full days have passed since they were last in a country not on the travel corridors list.

To opt into the scheme, visit https://www.gov.uk/provide-journey-contact-details-before-travel-uk

You must complete this form within 48 hours of arriving back in the UK and will require your booking reference number and name of the test provider.

To view the list of test and release testing providers, visit; https://www.gov.uk/government/publications/list-of-private-providers-of-coronavirus-testing/list-of-private-providers-of-coronavirus-testing

It is important to keep up to date with government guidelines by visiting https://www.gov.uk/guidance/travel-advice-novel-coronavirus to find out more.

For further information please contact covidcustomersupport@randox.com

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Randox launches Mobile COVID-19 Lab for Workplace Testing

Randox launches Mobile COVID-19 Lab for Workplace Testing

11 December 2020: Randox launches Mobile COVID-19 Lab for Workplace Testing

World-leading diagnostics company Randox Laboratories has today unveiled a new Mobile Laboratory Service which will offer rapid and reliable COVID-19 workplace testing.

The service from Randox, which is the largest COVID-19 testing provider in the UK and Ireland, and a partner in the UK Government’s National COVID-19 Testing Programme, uses gold standard PCR technology to generate results in 1 – 3 hours.

Each Mobile Laboratory will be capable of processing up to 1000 samples per day, to allow employers to uphold COVID safety within the workplace and maintain maximum output.

Dr Peter FitzGerald, Randox Managing Director, said;

“As the nation continues to navigate the working challenges caused by the COVID-19 pandemic, an increasing number of organisations will want to implement a COVID-19 testing regime so that they can sustain safe working environments.

 “With this in mind we continue to expand our portfolio of bespoke testing products and services, and our latest addition, the Mobile Testing Laboratory, in conjunction with our work within the National Testing Programme, brings us one step closer to a timely return to a more normal society.”

As part of the Randox Mobile COVID-19 testing service, a team of healthcare professionals will collect the samples on site, and a Laboratory Technician will subsequently expedite the sample and reports the results.

The Mobile Laboratory is available across the UK from 14th December 2020.

Dr FitzGerald continued;

“Since a new study by researchers at the University College London revealed that 86% of people who tested positive for COVID-19 did not have virus symptoms1, frequent screening of asymptomatic patients, is vital to identify any hotspots and limit further spread.

 “Our Mobile COVID-19 Laboratory, which uses gold standard PCR technology and can visit the location of your choice for immediate service, will promote safe working practices, allow companies to demonstrate their commitment to their staff, and facilitate recovery of the UK economy.”

The Randox Mobile COVID-19 Laboratory comes fully staffed and stocked for testing, and is suitable for any and all industries – Construction, Aviation, Hospitality, Retail and more.

Find out more at https://www.randoxhealth.com/mobile-covid-19-testing-laboratory/

For further information please email mobiletesting@randox.com

 

References

    1 https://www.ucl.ac.uk/news/2020/oct/symptoms-covid-19-are-poor-marker-infection  

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    Randox launches €99 Express COVID-19 Testing Service at Dublin Airport

    Randox launches €99 Express COVID-19 Testing Service at Dublin Airport

    16 November 2020: Randox launches 99 Express COVID-19 Testing Service at Dublin Airport

    A 99 Express COVID-19 Testing Service which launches this week in a new Travel Testing Centre at Dublin Airport, will see the creation of 50 new jobs.

    The testing service from Randox, a laboratory partner in the UK’s National COVID-19 Testing Programme, utilises a robust and reliable method of testing known as PCR, which Junior Minister for Transport Hildegarde Naughton described as “the gold standard” for travel testing.

    The launch of the Randox Health Travel Centre, which offers rapid next day delivery of results for pre-departure screening as well as on-arrival testing to reduce quarantine timeframes, comes just after Ireland aligned itself with the new EU ‘traffic light’ system to co-ordinate international travel, on Sunday 8th November.

    Sophie Boyd, Project Manager for the Randox Express COVID-19 Testing Service, explained;     

     “With the introduction of the new EU traffic lights system, some people will need a COVID-19 test before travelling or equally, will want a negative test result simply for their peace of mind.

    “We are delighted to have secured a location at Dublin Airport, that allows us to extend our rapid and reliable COVID-19 Testing Service, already used by a range of well-known companies, airlines and elite sporting organisations, to individual passengers and consumers.”

    The Irish Government has agreed that, whilst those arriving from red zones currently have to quarantine for 14 days, this could soon be waived following a negative result from a COVID-19 PCR test taken five days after arrival in Ireland.

    Sophie continued;

    “Travel requirements during the pandemic continue to evolve, but with the introduction of the EU traffic light system, a common prerequisite to travel or to shorten existing quarantine periods will be a negative PCR COVID-19 test, which is currently the only method of COVID-19 testing recognised and approved by every country worldwide.

    “With significant capacity in place to implement high volume PCR testing, we welcome the opportunity to bolster the travel industry’s enormous efforts to restore public confidence in international travel.

    “We are committed to providing the most cost-effective and accurate test in the market to assist with the normalisation of travel, and so Randox will be opening a number of regional travel centres across Ireland over the coming weeks.”

    Dublin Airport Managing Director Vincent Harrison said the health and safety of passengers and staff had been the airport’s key priority during the pandemic and that continued to be the case;

    “We continue to operate a range of globally-recognised COVID-19 safety measures for the health and wellbeing of all airport visitors, and with the official opening of the Randox Health Travel Centre at Dublin Airport we can further support our passengers by offering them access to testing facilities onsite at the airport.”

    The Randox €99 Express COVID-19 Testing Service is open to all asymptomatic individuals and operates from the Randox Health Travel Centre beside Terminal 2 at Dublin Airport, as well as at a testing facility in Leopardstown Dublin.

    In the coming weeks Randox Health Travel Centres will also open in Galway, Limerick and Cork.

    Visit booking.randox.ie to book your appointment.

    For further information please email info@randoxhealth.com or phone 0800 2545 130.

       

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      New Express COVID-19 Testing Service with next day results launched in Dublin

      New Express COVID-19 Testing Service with next day results launched in Dublin

      06 November 2020: New Express COVID-19 Testing Service with next day results launched in Dublin

      A new express COVID-19 testing service has now launched in Ireland, with a rapid next day delivery of results.

      From global diagnostics provider Randox, a laboratory partner in the UK’s National COVID-19 Testing Programme, the service utilises a robust and reliable method of testing known as PCR, the only method recognized and approved for travel testing.

      The PCR testing, which Junior Minister for Transport Transport Hildegarde Naughton described as “the gold standard,” is available in Dublin for pre-travel clearance, or simply for those wanting a COVID-19 test for peace of mind.

      Sophie Boyd, Project Manager for the Randox Express COVID-19 Testing Service, explained;     

       “We appreciate that many people will want a COVID-19 test before travelling home this Christmas, or equally, will want a negative test result to reduce quarantine times and enable them to spend more time with loved ones.

       “PCR testing is currently the only method of COVID-19 testing which is recognised by every country worldwide. Our rapid, accurate and reliable testing service, used already by a range of well-known companies, airlines and elite sporting organisations, will help get plans off to a hassle-free start for travellers and non-travellers alike.”

      The launch of the Randox testing service comes just as Ireland aligns itself with the new EU ‘traffic light’ system to co-ordinate international travel, on Sunday 8th November.

      The Government has agreed that, whilst those arriving from red zones currently have to quarantine for 14 days, this could soon be waived following a negative test result from a COVID-19 test taken five days after arrival in Ireland.

      Sophie continued;

      “Travel requirements during the pandemic continue to evolve, but with the introduction of the EU traffic light system, a common prerequisite will be a negative PCR COVID-19 test prior to travel or to shorten quarantine periods.

      “We have significant capacity in place to implement high volume testing and with our PCR testing service, we look forward to supporting the travel industry’s enormous efforts to restore public confidence in international travel.”

      The Randox Express COVID-19 Testing Service is priced at €99, is open to all asymptomatic individuals and operates from the Clayton Hotel in Dublin.

      Visit booking.randox.ie to book your appointment.

      For further information please email info@randoxhealth.com or phone 0800 2545 130.

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        EU Traffic Light System: How to get a COVID-19 PCR test before travelling

        12 October 2020

        EU Traffic Light System: How to get a COVID-19 PCR test before travelling

        EU Traffic Light System: How to get a COVID-19 PCR test before travelling

        As Covid-19 infection rates continue to rise in many parts of the world, an increasing number of countries are asking for a negative PCR test as a means of proof that travellers do not have the Covid-19 virus.

        Whilst not yet a common requirement globally, it is understood that the EU could soon be turning to a Traffic Light System that will require pre-departure testing for individuals departing any of the 15 ‘red list’ countries – which includes the UK and could be extended to include Ireland.

        Whilst there are currently a number of countries across the EU that do not require a negative COVID test for visitors from the UK, the implementation of this co-ordinated approach across the EU will place common requirements on all travellers from the UK, no matter which country they are visiting.

        It could also be used in support of reduced quarantine in those countries which require it.

        So – what is a PCR test?

        PCR stands for Polymerase Chain Reaction and is a method of testing used to detect infectious disease, including COVID-19.

        A PCR test is performed in a laboratory and is indicative of an individual’s COVID status at the time their sample is taken. It does not show previous infection.

        Where can I get a COVID PCR test done?

        PCR tests are available at Randox Health via an in-clinic appointment, or a home sample collection.

        Are home tests accepted as proof of my COVID status?

        It is important to note that many countries do not accept ‘home tests’ as proof of a negative COVID-19 result. Results must show that the test was performed in a certified laboratory.

        Whilst Randox Health offers a home sample collection kit, all our testing is performed using PCR methods in our certified laboratories.

        If the country you are travelling to requires a PCR test result, we’ve got you covered.

        How do I know if I need a COVID PCR test?

        You can check the entry requirements for your destination at gov.uk/foreign-travel-advice

        Requirements are subject to change, so keep checking in the weeks and days leading up to your trip.

        When do I take my sample for testing?

        Your destination country will determine the time frame required for testing. For example, it may state that your sample needs to be taken and tested within 72 hours before departure / arrival. You cannot be swabbed before this time.

        It is best to book / order your test in advance and take it as early as possible within your window, so that you allow for the maximum amount of time to get your test results back.

        How long do I wait for my results?

        Upon receipt of sample at Randox’s laboratories, you will receive your results within 24 hours.

        Our rapid, accurate and reliable COVID-19 testing service will help get your trip off to a hassle-free start, with minimum disruption to your travel plans.

        Visit https://www.randoxhealth.com/covid-travel-certificate/ to order your home sample collection kit or book your clinic appointment.

        For further information please email info@randoxhealth.com or phone 0800 2545 130.

           

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          Randox selected to screen travellers to the UAE for Covid-19

          02 September 2020

          Randox selected to screen travellers to the UAE for Covid-19

          Randox Laboratories selected to screen travellers to the UAE for Covid-19, with six sample collection centres across the United Kingdom and Ireland

          Randox Laboratories has been selected by Pure Health, the largest laboratory network in the UAE, to test airline passengers flying into the United Arab Emirates, in accordance with the UAE’s requirement for travellers to prove they are not infected with Covid-19. Pure Health has been appointed by the UAE’s government to launch this pioneering project to promote safe travel.

          “We are delighted to support Pure Health in their efforts to control the Covid-19 pandemic and facilitate safe travels for passengers flying into the UAE,” said David Adamson, Randox Laboratories, Business Development Manager.

          “As one of the largest diagnostic facilities in UK, we are ideally placed to successfully deliver this ambitious initiative, and we are grateful for the trust placed in us.”

          Randox Laboratories has already set up six collection centres across United Kingdom and Ireland. The programme is already up and running in London, Liverpool, Glasgow, Belfast, Antrim and Dublin.

          “The UAE has trusted Pure Health with safeguarding it against any incoming Covid-19 threats, worldwide, this responsibility requires us to ensure we only partner with verified and accredited facilities around the world, thus why we have partnered with Randox Laboratories, to ensure that the screening process is of the highest quality and to ensure an excellent customer service for the travellers.” said Maria El Houari, International Passenger Screening Project Manager at Pure Health.

          The UAE issued regulations that require all travellers flying into the UAE to provide proof of a negative Covid-19 test. Travellers without such a certificate are refused entry into the flight.

          The system is similar to the ESTA process in the United States. The traveller visits screening.purehealth.ae, chooses a testing location, selects a time slot, and completes the test at the agreed time and place. Test results are then transmitted to the UAE authorities, who use the data to cross-check arriving travellers against the border control database.

            For further information please email randoxpr@randox.com

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            Dr Peter FitzGerald: “Nothing will ever be the same again.”

            Dr Peter FitzGerald: Nothing will ever be the same again.

            An Interview with Ulster Business Editor John Mulgrew in The Belfast Telegraph, in which Dr FitzGerald speaks to John about developing and helping roll out millions of tests for Covid-19, a forever changed society, the high likelihood of a similar pandemic returning and when a vaccine for the virus could be found.

            Dr Peter FitzGerald’s expertise and opinion has probably never been taken as seriously as it has in the last few months.

            “Nothing will be the same again,” he tells Ulster Business. And, of course, he’s right.

            His firm Randox – based in Antrim – has been on the front line of testing for Covid-19 right across the UK and beyond. And as a result, he’s hired hundreds of new staff and built a £30m testing lab to deal with additional deluge of work resulting from a global pandemic unlike anyone here has ever seen.

            “I think there is a reasonable chance there will be more pandemics, with globalisation and increased population,” he told Ulster Business. “I have no idea how much it will come back again in second wave.

            “We know we have the capacity as a company to respond, and respond well. I suspect the country is going to be better prepared… it’s hard to predict.”

            The medical testing giant’s first involvement with the current coronavirus strain began back in January, before it became an increasingly concerning dinner conversation in homes across Northern Ireland.

            “In late January, research called and were looking at doing a test,” Peter said. “We downloaded the genetic sequence of the virus and spent the next two weeks developing a test. We can do it very quickly, as we already had coronaviruses on chip.

            “It was sent to Public Health England, which took a while to prove it. We then got a contract to test for the NHS… we were doing what we thought was for the national good.”

            The initial deal didn’t include all of the UK, but Randox is now also testing Northern Ireland.

            “We do the testing and we have different analysers that do the testing as well, which we sell to labs across the world.”

            The virus has led to a new complete lab being built (in which Peter is pictured in) to deal with the additional testing. “We decided to accelerate the manufacturing in our Randox Science Park in Antrim,” he says.

            As a result, it has hired around 200 staff in the space of six to eight weeks to deal with the surge.

            “Because we had closely related strains of the virus, it was wasn’t so difficult to modify our tests to allow for slightly different variations… once we got the contract we soon realised that we didn’t have enough lab space to deal with the ramp up.

            “We then decided to be 33,000 sq ft of new lab space, and it was needed in three weeks. We got that done – work was 24 hours a day, and seven days a week. It’s now operating well. That has been very important in the process.”

            Randox had a workforce of around 1,450 worldwide before the coronavirus crisis began, but has since taken on around 280 additional staff for a range of roles, partly in ramping up demand for the additional testing.

            “A lot were being taken on a temporary basis but many will be permanent. We are not sure of the final numbers, but well over 100.” Those roles include scientists, manufacturers, and engineers.

            “Nothing will be the same again,” Peter says. “What it has done is heightened the importance of testing. People sometimes don’t know what we do here at Randox… but people now realise.

            “In the end, it’s a good thing. We are advocates of testing. It identities disease before symptoms occur and can save lives in many occasions. It saves lives and saves costs. It fits in with what we have been trying to do for years… as far as we are concerned, it’s the silver lining.

            “We have customers worldwide and other products kept going. We moved around 100 scientists into Covid-related things and then they have gone back to normal jobs as we bring in new people.

            “Some of our R&D projects have changed, new systems and new analysers allow for efficient and accurate testing.”

            Peter says that just a small element of the business has seen a decrease amid the crisis, while other areas around Covid-19 have grown. “Only a small element of core business decreased. But our Covid and other genetic products have increased… overall sales will be up and by end of year normal business up as well.”

            As a result of the latest expansion and growth across the business, generally speaking, Peter says the workforce looks set to climb to 1,650, with around 500-600 based at its main headquarters, just outside Antrim.

            Peter’s also keen to reiterate the importance of Northern Ireland and its people to Randox. “This is our home base. It’s where we do our primary R&D and manufacturing. We also have a facility in Donegal.”

            And, could all of this happen again soon, with a further outbreak or a similarly devastating strain or pandemic?

            “(We are) more prepared and our technology is getting more accepted through bio chips. Early detection is a very important next stage. You don’t want people who have a cough or fever to think they have Covid all the time. That is where testing comes in and that differentiates.”

            Peter says the next stop forward in a bid to address similar future incidents it also understanding how our immune systems work – better.
            “The other major step forward in many ways is understanding the immune system better. How to better respond to infection. This will be very important.

            “Some people are susceptible, and this could be genetic. (It’s about) working on certain genes in those who may have a bad attack. It will prepare humans better, the body’s defence, dealing with it as well.

            “I have a deficiency in a particular gene which means I’m more susceptible to respiratory (conditions) but the spin-off of the gene means I’m less susceptible to certain cancers. This is the issue – it is so complex. One could be a strength and one moment, a weakness.”

            And as for the formulation of a proven vaccine, Peter says: “I would say it would be well into next year.”

              For further information please email randoxpr@randox.com

              Photo Credit Elaine Hill

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              COVID-19 Testing Service Testimonial: The Irish Football Association

              News       About Us       COVID-19

               

              25 July 2020

              COVID-19 Testing Service Testimonial: The Irish Football Association

              As we move towards a new ‘normal’ and sporting organisations begin the process of restarting their games, many teams will be wondering how to ensure a safe and reassuring training environment for their players and their staff.

              Thanks to our COVID-19 testing service, The Irish Football Association was able to facilitate a timely and efficient return to play by confirming their players as ‘COVID-safe.’

              Our ‘Back to Business’ programme has enabled the IFA to demonstrate their commitment to their players, their staff, and their fans, as well as get back to business by ensuring the highest level of safety.

              Corinne Lannie, Risk Manager at the Irish Football Association, commented;

              “The test kits were very straightforward to use.  The instructions were clear as was the YouTube guidance video. The recording onto the Randox system was easy and the speed of results was exceptional.

              “The support provided by Paul (Randox Business Development Executive) was amazing – he was extremely helpful and supportive and really went above and beyond.”

              At Randox, we offer two types of testing;

              PCR (diagnostic) testing, and antibody testing, which can give an indication that an individual has been previously infected with COVID-19.

              Sample collection services are available.

              David Hallendorff, Business Relations Manager at Randox Health commented;

              “Collectively we are all working towards a timely return to a more normal society, which will see companies reopening and people returning to work.

              “To facilitate this recovery of the economy, without compromising the health of workers or of the wider general public, workplaces have a responsibility to provide a safe working environment.

              “It is great to see so many companies putting the health of their staff as a priority and taking a proactive approach to testing.

              To find out more about our Back to Business COVID-19 Testing Service, please email info@randoxhealth.com or phone 0800 2545 130

               

               

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              • Rejestracja na naszej liście mailowej jest szybka i łatwa. Nie chcemy wysyłać e-maili zawierających spam lub wiadomości, które są automatycznie przekierowywane do kosza. W zawiązku z czym firma Randox deklaruje, że będzie wysyłac tylko informacje na temat nowych produktów,akutalizacji obecnych, trendów rynkowych, wydarzeń branżowych itp. Firma Randox Laboraotries obiecuje, że Państwa dane nie będą nigdzie przekazane, a przechowywanie owych danych będzie się odbywało z zachowaniem największego bezpieczeństwa. Prosimy o przeczytani naszje Polityki Prywatności.
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              • Rejestracja na naszej liście mailowej jest szybka i łatwa. Nie chcemy wysyłać e-maili zawierających spam lub wiadomości, które są automatycznie przekierowywane do kosza. W zawiązku z czym firma Randox deklaruje, że będzie wysyłac tylko informacje na temat nowych produktów,akutalizacji obecnych, trendów rynkowych, wydarzeń branżowych itp. Firma Randox Laboraotries obiecuje, że Państwa dane nie będą nigdzie przekazane, a przechowywanie owych danych będzie się odbywało z zachowaniem największego bezpieczeństwa. Prosimy o przeczytani naszje polityki prywatności.
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