D-3 Hydroxybutyrate (Ranbut)

Home - Reagents - D-3 Hydroxybutyrate (Ranbut)
Randox Acetaminophen Reagent

Key Benefits

Excellent precision

The Ranbut assay showed a precision of less than 3.5% CV

Exceptional correlation

The assay showed a correlation of r=0.9954 against another commercially available method

Wide measuring range

The Randox Ranbut assay has a wide measuring range of 0.100 – 5.75 mmol/l, capable of detecting abnormal levels in a sample

Randox D-3 Hydroxybutyrate (Ranbut)

  • Enzymatic method
  • Lyophilised reagents
  • Reconstituted stability of 7 days at 2-8⁰C
  • Measuring range 0.100 – 5.75 mmol/l
Cat NoSizeAnalyserEasy Read
Easy Fit
 
(S) Indicates standard included in kit
RB100710 x 10ml (S)General Use--
RB100810 x 50ml (S)General Use--

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is D-3 Hydroxybutyrate (Ranbut) assay used for?

D-3 Hydroxybutyrate is the major ketone body in the blood. The nitroprusside method of ketone detection, used in semi-quantitative dipstick tests detects acetone and acetoacetate, but not D-3 Hydroxybutyrate. During ketosis, D-3 Hydroxybutyrate levels increase more than the levels of acetone and acetoacetate, making D-3 Hydroxybutyrate a more sensitive marker of ketosis. D-3 Hydroxybutyrate is the most stable of the ketone bodies (7 days at +4⁰c) – acetone and acetoacetate are unstable, so serious errors can arise if analysis is delayed. D-3 Hydroxybutyrate can be used for the detection of ketosis is important in a number of conditions:

  • Diabetic ketosis
  • Alcoholic ketosis
  • Severe injury, illness or sepsis
  • Dieting
  • Childhood epilepsy
  • Ketotic hypoglycaemia
  • Nishina, H., et al. Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep. J. Physiol. 2003, 553(2): 637-647
  • Graaf-Roelfsema, E. et al. Effects of short -and long-term recombinant equine growth hormone and short-term hydrocortisone administration on tissue sensitivity to insuline in horses. American Journal of Veterinary Research. 2005, 66(11): 1907-1913
  • Miyashita, M., et al. Exercise and postpandrial lipemia: effect of continuous compared with intermittent activity patterns. Am. J. Clin. Nutr. 2006, 83(1): 24-29
  • Geddes J., et al. Cardiac troponin I concentrations in people presenting with diabetic ketoacidosis. Ann. Clin. Biochem. 2007, 44(4): 391-393
  • Li, L., et al. LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signalling. Am. J. Physiol. Endocrinol. Metab. 2007, 293: E587-E594
  • Sinclair, L.A., et al. Effect of rate of substitution of processed, urea-treated whole-crop wheat for grass silage on the intake, milk production and diet digestibility in dairy cows and ruminal metabolism in vitro. Animal. 2007, 1: 601-611
  • Wathes, D.C., et al. Differences between primiparous and multiparous dairy cows in the inter-relationships between metabolic traits, milk yield and body condition score in the periparturient period. Domestic Animal Endocrinology. 2007, 33(2): 203-225
  • Begriche. K., et al. Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice. Am. J. Physiol Endocrinol Metab. 2008, 294: E939-E951
  • Keogh, J.B., et al. Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity1, 2, 3. Am. J. Clin. Nutr. 2008, 87(3): 567-576
  • Nylen, K., et al. A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype. Exp. Neurol. 2008, 210(2): 449-457
  • Bruce, K.D., et al. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology. 2009, 50(6): 1796-1808
  • Freemantle, E. et al. Metabolic response to ketogenic breakfast in the healthy elderly. J. Nutr. Health Aging 2009, 13(4): 293-298
  • Kalmus P., et al. Effect of yeast culture on milk production and metabolic reproductive performance of early lactation dairy cows. Acta Veterinaria Scandinavica. 2009, 51: 32
  • Marton A., et al. Milk progesterone profiles, blood metabolites, metabolic hormones and pregnancy rates in Awassi ewes treated by gestagen + eCG at the early breeding season. Veterinarni Medicina, 2009, 54: 507-516
  • Tremblay-Mercier, J. et al. Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects. J. Pharmacol. Exp. Ther. 2010, 334(1): 341-346
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  • Signing up to our mailing list is quick and easy. We do not wish to send you any spam or junk email, therefore, you can expect to receive mailshots including new product launches and updates, market trends, attendance at key industry events and much more. Randox Laboratories promise never to sell your data and we will keep all your details, safe and secure. Read more in our Privacy Policy (https://www.randox.com/privacy-cookies/)
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  • Signing up to our mailing list is quick and easy. We do not wish to send you any spam or junk email, therefore, you can expect to receive mailshots including new product launches and updates, market trends, attendance at key industry events and much more. Randox Laboratories promise never to sell your data and we will keep all your details, safe and secure. Read more in our Privacy Policy (https://www.randox.com/privacy-cookies/)
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