D-3 Hydroxybutyrate (Ranbut) Reagent

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D-3 Hydroxybutyrate

Key Benefits of the Randox D-3 Hydroxybutyrate (Ranbut) reagent

Excellent precision

The Randox D-3 Hydroxybutyrate (Ranbut) assay showed a precision of less than 3.5% CV

Exceptional correlation with standard methods

The Randox methodology was compared against other commercially available methods and the Randox Ranbut assay showed a correlation coefficient of r=0.9954

Wide measuring range

The healthy range for D-3 Hydroxybutyrate in serum is 0.4 – 0.5 mmol/l. The Randox Ranbut assay can comfortably detect levels outside of the healthy range measuring between 0.100 – 5.75 mmol/l.

Other features of the Randox D-3 Hydroxybutyrate (Ranbut) reagent

  • Enzymatic method
  • Liquid & Lyophilised reagents
  • Reconstituted stability of 7 days when stored between +2 to +8⁰C
  • Measuring range 0.100 – 5.75 mmol/l
Cat NoSizeAnalyserEasy Read
Easy Fit
 
(L) Indicates liquid option (S) Indicates standard included in kit
RB100710 x 10ml (S)General Use--
RB100810 x 50ml (S)General Use--
RB4067R1 2 x 20ml (L)
R2 2 x 5.8ml
RX Imola--
RB8378R1 2 x 20ml (L)
R2 2 x 6.1ml
RX Daytona+--

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the D-3 Hydroxybutyrate (Ranbut) assay used for?

What is D-3 Hydroxybutyrate (Ranbut)?

D-3 Hydroxybutyrate is the major ketone body produced in the liver due to the oxidation of fatty acids. It is transported in the blood to peripheral tissues and used as an energy source. The nitroprusside method of ketone detection, used in qualitative dipstick tests, detects acetone and acetoacetate, but it does not detect D-3 Hydroxybutyrate. The nitroprusside method is also prone to interferences from sulfhydryl medications and the levels of ketones present in urine often lag between 2 to 4 hours behind the levels in blood.

What is the D-3 Hydroxybutyrate (Ranbut) assay used for?

The Randox D-3 Hydroxybutyrate (Ranbut) assay is used for the quantitative in vitro determination of D-3 Hydroxybutyrate in serum or plasma. Randox test for D-3 Hydroxybutyrate as opposed to acetone or acetoacetate because D-3 hydroxybutyrate is a more sensitive biomarker of ketosis as the D-3 Hydroxybutyrate levels are more elevated compared to acetone and acetoacetate. D-3 Hydroxybutyrate is also the most stable ketone body (7 days at +4⁰C) – Acetone and acetoacetate are unstable, and so serious errors can arise if analysis is delayed. The Randox D-3 Hydroxybutyrate (Ranbut) assay can be used for the detection of ketosis is important in several conditions:

  • Diabetic ketosis
  • Alcoholic ketosis
  • Severe injury, illness or sepsis
  • Dieting
  • Childhood epilepsy
  • Ketotic hypoglycaemia

For more information of ketosis, please click here [external link].

  • Nishina, H., et al. Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep. J. Physiol. 2003, 553(2): 637-647
  • Graaf-Roelfsema, E. et al. Effects of short -and long-term recombinant equine growth hormone and short-term hydrocortisone administration on tissue sensitivity to insuline in horses. American Journal of Veterinary Research. 2005, 66(11): 1907-1913
  • Miyashita, M., et al. Exercise and postpandrial lipemia: effect of continuous compared with intermittent activity patterns. Am. J. Clin. Nutr. 2006, 83(1): 24-29
  • Geddes J., et al. Cardiac troponin I concentrations in people presenting with diabetic ketoacidosis. Ann. Clin. Biochem. 2007, 44(4): 391-393
  • Li, L., et al. LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signalling. Am. J. Physiol. Endocrinol. Metab. 2007, 293: E587-E594
  • Sinclair, L.A., et al. Effect of rate of substitution of processed, urea-treated whole-crop wheat for grass silage on the intake, milk production and diet digestibility in dairy cows and ruminal metabolism in vitro. Animal. 2007, 1: 601-611
  • Wathes, D.C., et al. Differences between primiparous and multiparous dairy cows in the inter-relationships between metabolic traits, milk yield and body condition score in the periparturient period. Domestic Animal Endocrinology. 2007, 33(2): 203-225
  • Begriche. K., et al. Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice. Am. J. Physiol Endocrinol Metab. 2008, 294: E939-E951
  • Keogh, J.B., et al. Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity1, 2, 3. Am. J. Clin. Nutr. 2008, 87(3): 567-576
  • Nylen, K., et al. A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype. Exp. Neurol. 2008, 210(2): 449-457
  • Bruce, K.D., et al. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology. 2009, 50(6): 1796-1808
  • Freemantle, E. et al. Metabolic response to ketogenic breakfast in the healthy elderly. J. Nutr. Health Aging 2009, 13(4): 293-298
  • Kalmus P., et al. Effect of yeast culture on milk production and metabolic reproductive performance of early lactation dairy cows. Acta Veterinaria Scandinavica. 2009, 51: 32
  • Marton A., et al. Milk progesterone profiles, blood metabolites, metabolic hormones and pregnancy rates in Awassi ewes treated by gestagen + eCG at the early breeding season. Veterinarni Medicina, 2009, 54: 507-516
  • Tremblay-Mercier, J. et al. Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects. J. Pharmacol. Exp. Ther. 2010, 334(1): 341-346

Diabetes Panel

For more information or to view more reagents within the diabetes panel, please click here

Veterinary Panel

For more information or to view more reagents within the veterinary panel, please click here

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