Fructosamine Reagent

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Randox Reagents Fructosamine

Key Benefits of the Randox Fructosamine Assay

Standardisation to the highest level

The Randox fructosamine calibrator and control are assigned relative to human serum glycated with 14C-glucose, and so standardization is of the highest level, directly reflecting the nature of the patient sample.

Enzymatic method

Offering improved specificity and reliability compared to the conventional NBT-based methods. The Randox enzymatic method does not suffer from non-specific interferences unlike the existing methods which can also be time-consuming and difficult to automate.

Excellent stability

Stable on board the analyser for 28 days when stored at +10oC.

Further Benefits of the Randox Fructosamine Assay

Liquid ready-to-use format for convenience and ease-of-use.

Measuring range of 8.12 – 1803µmol/l for the comfortable detection of abnormal levels.

Applications available detailing instrument-specific settings for the convenient use of the Randox fructosamine assay on a wide range of clinical chemistry analysers.

Cat NoSize    
FR3133R1 5 x 25ml
R2 5 x 6.3ml
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FR4030R1 4 x 19.8ml
R2 4 x 6.9ml
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Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

About Fructosamine Testing

  • Clinical Significance
  • Biological Significance
  • Drawbacks of Traditional Diabetes Tests

Fructosamine has been identified as an early indicator of diabetic control compared to other markers such as HbA1c. Red blood cells live for approximately 120 days, glycated haemoglobin (HbA1c) represents the average blood glucose levels for the previous 2 to 3 months. Conversely fructosamine has a shorter lifespan, about 14 to 21 days, reflecting average blood glucose levels from the previous 2 to 3 weeks. Due to the shorter time span of fructosamine, it is also used to evaluate the effectiveness of medication changes and to monitor the treatment of gestational diabetes. The test is also particularly useful in situations where HbA1c cannot be reliably measured e.g. haemolytic anaemia, thalassemia or with genetic haemoglobin variants 1.

In a diabetic patient where blood glucose levels are abnormally elevated, the concentration levels of fructosamine also increase as fructosamine is formed by a non-enzymatic Maillard reaction between glucose and amino acid residues of proteins. During this glycation process, an intermediate labile Schiff base is produced which is converted to a more stable ketoamine (fructosamine) via an Amadori rearrangement 2.

The Fasting Plasma Glucose (FPG) test measures the level of blood sugars which is used to diagnose and monitor diabetes based on insulin function. The main drawback of this test is that a hormone called glucagon, produced in the pancreas, is triggered during prolonged fasting, signalling the liver to release glucose into the bloodstream. In diabetic conditions, either the body is unable to generate enough insulin or cannot appropriately respond to insulin. Consequently, FPG levels remain high 1.

In the1980’s, HbA1c was incorporated into clinical practice as HbA1c levels correlated well with glycaemic control over a 2 to 3-month period. The main drawback of this test is that any condition that reduces the survival rate of erythrocytes such as haemolytic anaemia will falsely lower the HbA1c test results regardless of the assay method utilised 3.

Diabetes Panel

For more information or to view more reagents within the diabetes panel, please click here

Veterinary Panel

For more information or to view more reagents within the veterinary panel, please click here

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