Reagent | Immunoglobulin (IgE)
A Marker of Allergic Diseases
A correlation coefficient of r=1.00 was displayed when the Randox methodology was compared against commercially available methods.
The Randox IgE assay displayed a precision < 4.0% CV.
Excellent measuring range
The Randox IgE assay has a measuring range of 25 – 1000 IU/ml for the comfortable detection of clinically important results.
The Randox IgE assay is available in a liquid ready-to-use format for convenience and ease-of-use.
Calibrator and controls available
Dedicated IgE calibrator and specific protein controls available for a complete testing package.
Applications available detailing instrument-specific settings for the convenient use of the Randox IgE assay on a variety of clinical chemistry analysers.
|IE7308||R1 1 x 8ml (L)|
R2 1 x 5ml
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|(L) Indicates liquid option|
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
Immunoglobulin E (IgE) is one of five classes of immunoglobulins (IgA, IgD, IgE, IgG and IgM). IgE was the last immunoglobulin to be discovered. However, since it’s discovery, vast amounts of research have been aimed at characterising its physiological and clinical significance’s. Whilst IgEs chemical structure is unique compared to the rest of the immunoglobulin family (lacks a ‘hinge’ region in the centre of the molecule and gets replaced by the C-epsilon2 domain), it has an array of physiological functions. For immunoglobulin E to fulfil its function, the Fc portion of the antibody must bind to a given cellular receptor located on certain cell types, such as eosinophil or mast cells. Whilst many an array of cellular receptors have been identified, the main ones are Fc-epsilon-RI, Fc-epsilon-II and CD23. Fc-epsilon-RI is the high affinity receptor located on basophils, dendritic cells, eosinophils, mast cells and macrophages and is responsible for immediate hypersensitivity reactions, enhanced cytokine production, parasitic immunity, and antigen presentation 1.
It is believed that immunoglobulin E evolved as a defence mechanism against parasitic infestation. The major sites of parasitic invasion are the gut, respiratory tract and skin, the typical allergic response sites. IgE antibodies play a key role in the early recognition of foreign material or a general potentiation of the immune system response through improved antigen presentation. An allergy triggered by IgE could be beneficial to the host as the typical allergic reactions include: sneezing, coughing, inflammation, bronchoconstriction and vomiting, to expel allergenic proteins from the body. Different allergens stimulate the production of corresponding allergen-specific immunoglobulin E antibodies 2. The antigen-dependent activation of tissue mast cells that have specific immunoglobulin E bound to their surface is the central event in acute allergic reactions. IgE specific allergens include: allergic or atopic asthma, atopic dermatitis (eczema), food allergies such as peanut and shellfish, allergic rhinitis (hay fever), house dust mite, latex allergy, dog or cat allergies 2, 3.
Specific Proteins Controls
 Godwin L, Crane JS. Biochemistry, Immunoglobulin E (IgE).Treasure Island (FL): StatPearls Publishing; 2019. https://www.ncbi.nlm.nih.gov/books/NBK541058/ (accessed 18 March 2020).
 Galli SJ, Tsai M. IgE and mast cells in allergic disease. Nature Medicine 2012; 18(5): 693-704.
 Sheldon J, Miller L. Allergy Diagnosis Reference Guide. https://www.mtw.nhs.uk/wp-content/uploads/2015/08/Allergy_diagnosis_reference_guide.pdf (accessed 19 March 2020).