Reagent | Albumin
A Marker of Hepatic Dysfunction
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Excellent precision
The Randox albumin assay displayed a within run precision of < 1.97%.
Calibrator and controls available
Calibrator and controls available for a complete testing package.
Working Stability
Working reagent stable up to 3 months when stored at +15oC to +25oC.
Flexibility
Liquid and Lyophilised Reagents available for greater customer choice.
Applications available
Applications available detailing instrument-specific settings for the convenient use of the Randox albumin assay on a variety of clinical chemistry analysers.
Ordering information
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
| Cat No | Size | ||||
|---|---|---|---|---|---|
| AB362 | 6 x 13.5ml (S) | Enquire | Kit Insert Request | MSDS | Buy Online |
| AB3800 | 9 x 51ml (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
| AB8000 | 4 x 68ml (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
| AB8301 | 4 x 20ml (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
(L) Indicates liquid reagent |
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Clinical Significance
Albumin is the most abundant circulating protein found in plasma, representing approximately half of the total protein content in health human plasma. Synthesised by liver hepatocytes, it is rapidly excreted into the bloodstream, approximately 10gm – 15gm per day, with little remaining in the liver 1. It is responsible for the maintenance of colloidal osmotic pressure, provision of the majority of plasma antioxidant activity, and the binding of a variety of compounds 2.
A correlation between serum albumin concentrations and ill-health has been identified, with an astonishingly strong inverse correlation between serum albumin and mortality risk 2. The association of it with other confounding variables increase mortality (fig 1). The concentration is related to the rates of synthesis and catabolism, but also influenced by state of hydration, lymphatic return, external losses (burns), and rates of transcapillary escape. In starvation, both the synthesis and catabolism fall, whereas in nephrotic syndrome, synthesis rises and catabolism falls 3.
Fig. 1. Potential associations between serum albumin and mortality 3
A direct, casual relationship between serum albumin and mortality is represented by arrow a or the sequence b, a. A non-casual, confounding relationship is represented by arrows b and c. A co-causal relationship is represented by arrows a and c.
Low circulating albumin is associated with an adverse metabolic profile characterised by increased adipose tissue inflammation, glucose concentrations, and adiposity. It inversely correlates with type 2 diabetes mellitus (T2DM) risk 4. Moreover, serum albumin concentrations are inversely correlated with the risk of ketosis in hospitalised patients with T2DM and may require the early initiation of insulin therapy to prevent complications. It is a promising prognostic marker in hospitalised diabetic patients with acute hyperglycaemia 5.
Low levels of serum albumin is common in cirrhosis and is associated with a reduced survival rate. In this setting, the native isoform can be severely reduced as a result of several post-transcriptional changes that impair the non-oncotic properties of the molecule 6.
Hypoalbuminemia status has been associated with the critically ill and mortality across several clinical settings. Hypoalbuminemia can potentially lead to the early recognition of severe disease associated with COVID-19 and can assist clinicians in making informed decisions for their patients 7.
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References
