OLINK® | Comprehensive Biomarker Discovery

 

Let Experts at Randox Run Your Samples

As one of the UK’s first commercial partners of Olink® Proximity Extension Assay (PEA) technology, Randox offer scientists involved in drug development, clinical, or basic life science research, the service they need to run large-scale discovery proteomics.

 

Randox offer customers access to the entire Olink® protein library of ~3000 protein assays for exploratory proteomics and multiomics.

Olink® Technology- How it Works

Olink Proximity Extension Assay (PEA) technology offers a new method for measuring & detecting proteins of interest in a wide variety of sample types.

Using real-time PCR amplification, Olink platforms such as the Explore 3072 uses dual recognition with antibody- protein pairs in high multiplex to create 96 unique DNA reporter sequences. Using this approach, researchers can incorporate Olink’s kits into their workflow to measure and detect low abundance proteins whilst ensuring exceptional specificity and accuracy in serum or plasma samples.

The platform uses PEA technology combined with Next Generation Sequencing (NGS) readout methods to measure the relative concentration of proteins in liquid samples.

Workflow

Olink®- Driving the Future of Healthcare

Driven by precision medicine, the future of healthcare relies on a new generation of therapies to deliver the right treatment to the right patients at the right time. Proteomics is set to be at the forefront of this movement.

Technological limitations previously restricted comprehensive investigations of proteomics. Inhibiting large scale studies examining broad ranges of proteins in large numbers of human samples.

Olink® PEA technology provides an example as to how technological developments have eradicated past issues involving:

-Poor sensitivity

-Low throughput

-Large sample volume needed

-Lack of specificity

Features and Benefits

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    Covers all major biological pathways with ~3000 validated protein assays
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    High sample throughput for large scale proteomic studies and research
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    Minimal sample volume with just 60uL for the complete library
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    Exceptional specificity in comparison to mass spec utilising PEA technology
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    Compatible with a wide variety of sample types

Randox Successfully Completed Olink® Concordance Testing

Randox successfully completed the Explore Concordance challenge as beta testers of the Concordance program, certifying the ability to operate the PEA with the same level of competency as the Olink® Analysis Service.

Randox Summary Report Acceptance Criteria Result
QC Warnings0%Max 16% allowed Passed the QC warning criteria
Detectability97.2%Min 85% allowed Passed the detectability criteria
Intra CV9%Max 15% allowedPassed the CV criteria
Median correlation coefficient (r)0.98Min 0.9 allowedPassed the correlation criteria.
Coefficient of determination (R2)0.96Min 0.9 allowedPassed the correlation criteria.
Overall, Randox passed all QC criteria, successfully passing the Olink Concordance Test on Explore 3072.
Download Full Report

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