Reagent | Apolipoprotein C-III (Apo C-III)

An Independent Risk Factor for CVD

Benefits of the Randox Apo C-lll Assay

Limited Interference

Immunoturbidimetric method

The immunoturbidimetric method limits interference from Bilirubin, Haemoglobin, Intralipid® and Triglycerides, producing more accurate results.

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Exceptional correlation

A correlation coefficient of r=1.00 was displayed when the Randox apo C-III assay was compared to commercially available methods.

Wide Measuring Range

Excellent measuring range

The Randox apo C-III assay has a measuring range of 2.06 – 21.7mg/dl for the comfortable detection of clinically important results.

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Liquid ready-to-use

The Randox apo C-III assay is available in a liquid ready-to-use format for convenience and ease-of-use.

Calibrator & Controls

Dedicated calibrator and controls available

Randox offer dedicated apolipoprotein calibrator and controls for a complete testing package.

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Applications available

Applications available detailing instrument-specific settings for the convenient use of the Randox apo C-III assay on a variety of clinical chemistry analysers.

Ordering Information

Cat NoSize
LP3865R1 2 x 11ml (L)
R2 2 x 5ml
EnquireKit Insert RequestMSDSBuy Online
(L) Indicates liquid reagent

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

Clinical Significance

Not only is apo C-III a key regulator in the metabolism of triglycerides, but it is also an independent risk factor for CVD. Not only does apo C-III contribute to CVD through the regulation of triglycerides but also through its direct atherogenic effects, promoting atherosclerosis (fig 1) 1.

Fig. 1. Pleiotropic effects of apo C-III 1
Fig. 1. Pleiotropic effects of apo C-III

Physiological Significance

Apo C-III is composed of 79 amino acids and has a molecular weight of 8.8kDa. Apo C-III promotes hypertriglyceridemia via several mechanisms. Firstly, like apo C-II, apo C-III also inhibits the activity of LPL, distributing lipid lipolysis. Apo C-III hinders the binding of apolipoprotein B and apolipoprotein E to the hepatic receptors resulting in the delayed catabolism of triglyceride – rich lipoproteins (TRLs). Finally, apo C-III prefers the production and secretion of very low-density lipoproteins (VLDL) in the liver 1.

Useful links

Reagents Home

Apolipoprotein Control

Apolipoprotein Calibrator

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