Reagent | Cholinesterase (Butyryl) (BCHE / BuCHE)
Key Benefits of the Cholinesterase (Butyryl) (BCHE / BuCHE) reagent
Exceptional correlation with standard methods
The Randox methodology was compared against other commercially available methods and the Randox cholinesterase (butyryl) reagent showed a correlation coefficient of r=0.9959
Wide measuring range
The healthy range for cholinesterase (butyryl) is 3700 – 13200 U/l. The Randox cholinesterase (butyryl) reagent can comfortably detect levels outside of the healthy ranges measuring between 455 – 28722 U/l.
Stable for 6 weeks when stored at +2 to +8°C
Other features of the Cholinesterase (Butyryl) (BCHE / BuCHE) reagent
- Colorimetric method
- Lyophilised reagents
- Correlation coefficient of r=0.99 when compared with another commercially available method
- Stable for 6 weeks when stored at +2 to +8°C
- Wide measuring range 455 – 28722 U/l
What is the Cholinesterase (Butyryl) (BCHE / BuCHE) assay used for?
What is cholinesterase (butyryl)?
Cholinesterase (butyryl) (BCHE / BuCHE), also known as pseudocholinesterase, is a protein coding gene and is a serine hydrolase synthesised in the liver and is responsible for catalysing the hydrolysis of numerous choline esters. It can be found in the liver, intestinal mucosa, plasma, pancreas and the white matter of the central nervous system of mammals.
What is the cholinesterase (butyryl) assay used for?
The Randox Cholinesterase (butyryl) reagent is used for the quantitative in vitro determination of BCHE in serum and plasma. BCHE can be used to diagnose cholinesterase (butyryl) deficiency and curariform drugs toxicity.
The Randox Cholinesterase (butyryl) reagent can also be used as a diagnostic and therapeutic marker for Alzheimer’s disease as BCHE activity progressively increases in patients with Alzheimer’s disease whereas acetylcholinesterase activity remains the same or declines. In Alzheimer’s disease, BCHE is found in association with beta-amyloid plaques and the cerebral cortex, whereas it is not commonly found in any other case. A study carried out by NCBI found that when the BCHE gene is not found in the brain, there are up to 70% less beta-amyloid plaques. For more information on the diagnosis of Alzheimer’s disease, please click here [external link].