Randox Clinical Laboratory Services
Randox Clinical Laboratory Services (RCLS) specialises in offering esoteric biomarker testing utilising the expertise and knowledge Randox has built over 40 years producing high quality IVD diagnostics. RCLS strives to provide a clinical laboratory service to meet the time sensitive, bespoke requirements of research and clinical trial projects globally.
By utilising Randox Clinical Laboratory Services you can save your laboratory time and money. Our multiplex panels offer a cost effective, labour saving and time reducing solution for your sample testing. As a result, we provide your laboratory with the best solution for your sample testing.
Clinical laboratories traditionally perform diagnostic testing from a variety of patient samples (whole blood, serum, plasma, saliva, sputum, CSF, swab collections) to determine their health status.
In addition to Diagnostics, Randox Laboratories also perform Biomarker analysis from selected patient cohorts in support of pharma research, aiming at discovering a biological signal related to an NDE’s activity (targeted Biomarker approach) or a novel druggable target (proteomic analysis). Randox Biosciences offer multiple technical solutions to address the above, mostly based on the Randox proprietary Biochip Array Technology.
Sample & Data Management
– LIMS system (Labware) utilised and connected throughout the lab.
– Customer and project specific folders on an internal secure server
– Ability to transfer data securely through secure email/drop box
Capabilties
Randox Biosciences provide the building blocks of diagnostic development which includes antibodies, corresponding conjugates and proteins. Our immunoassay product offering provides diagnostic solutions covering a variety of disease areas including thyroid, reproduction, cardiovascular and renal.
Biochip Technology from Randox is an innovative assay technology which utilises multiplex testing methodology in a rapid, accurate and easy-to-use format, catering both molecular and immunoassay testing. The technology works by combining a panel of related assays in a single biochip with a single set of reagents, controls and calibrators. Only one single undivided sample is used. The results are read by a CCD-camera and custom image-processing software.
Custom Assay Development
Serving the diagnostic, pharmaceutical, contract research and biotech industries, Randox Biosciences dedicates custom unit develops and manufactures custom assay solutions. This also includes full customised quality control sera and calibrators. A selection of over 320 pre-qualified biomarkers is available for a custom panel design. However, any specific biomarker of interest will be considered for integration into an existing or desired panel, for technical feasibility (concentration range compatibility, potential interferences/cross-reactivities). The number of the required novel biomarkers will help make the feasibility study as a pertinent and complete as possible.
Companion Diagnostics (CDx) are part of the services that Randox Biosciences supply to pharmaceutical companies. With a long-recognized expertise in the development of esoteric assays, and more than 500 IVD products available globally, Randox is a partner of choice to support your CDx needs.
Full Assay Menu
| AKI Array | |||
| Lipocalin (NGAL) | Clusterin | Cystatin C | KIM-1 |
| ADHESION MOLECULES ARRAY | |||
| E-selectin | P-selectin | L-selectin | ICAM-1 |
| VCAM-1 | |||
| ANAEMIA ARRAY | |||
| Ferritin | Folate | Vitamin B12 | |
| ALZHEIMERS RISK ARRAY | |||
| Pan ApoE | ApoE4 | ||
| CEREBRAL ARRAY II | |||
| sTNFRI | NGAL | NSE | D-dimer |
| CKD ARRAY I | |||
| EGF | FABP1 | D-Dimer | IL-8 |
| MIP-1 α | sTNFRI | sTNFRII | |
| CKD ARRAY II | |||
| CYTOKINE ARRAY I | |||
| IL-1α | IL-1β | IL-2 | IL-4 |
| IL-6 | IL-8 | IL-10 | IFNγ |
| EGF | MCP-1 | TNFα | VEGF |
| CYTOKINE ARRAY IV | |||
| MMP-9 | sIL-2Rα | sIL-6R | sTNFRI |
| sTNFRII | |||
| CYTOKINE ARRAY V | |||
| IL-3 | IL-7 | IL-12p70 | IL-13 |
| IL-23 |
| FERTILITY ARRAY | |||
| Follicle Stimulating Hormone (FSH) | Luteinising Hormone(LH) | Prolactin Hormone (PRL) | Progesterone (PROG) |
| Estradiol (EST) | |||
| GASTROPANEL ARRAY | |||
| Pepsinogen I (PGI) | Pepsinogen II (PGII) | Gastrin 17 (G17) | |
| HELICOBACTER PYLORI ASSAY | |||
| Helicobacter Pylori (HP) |
| METABOLIC SYNDROME I ARRAY | |||
| Ferritin | IL-6 | Insulin | Leptin |
| Plasminogen Activator Inhibitor-1 (PAI-1) | Resistin | Tumour Necrosis Factor α (TNFα) | |
| METABOLIC SYNDROME II ARRAY | |||
| Adiponectin | C-reactive Protein (CRP) | Cystatin C | |
| PTH ASSAY | |||
| Parathyroid Hormone (PTH) | |||
| SHGB ASSAY | |||
| Sex Hormone-Binding Globulin (SHBG) | |||
| STROKE ARRAY | |||
| Soluble Tumour Necrosis Factor | Receptor 1 (sTNFR1) | Glial fibrillary acidic protein (GFAP) | IL-6 |
| Fatty acid binding protein 3 (FABP3) | D-Dimer | Parkinson Disease Protein 7 (PARK7) | Nucleoside Diphosphate Kinase A (NDKA) |
| Glutathione S-transferase, Pi (GSTP1) |
| TESTOSTERONE ASSAY | |||
| Testosterone | |||
| THYROID TOTAL ARRAY | |||
| Total thyroxine (TT4) | Total tri-iodothyronine (TT3) | Thyroid stimulating hormone (TSH) | |
| THYROID FREE ARRAY | |||
| Free thyroxine (FT4) | Free tri-iodothyronine (FT3) | Thyroid stimulating hormone (TSH) | |
| THYROID AUTO ANTIBODY ARRAY | |||
| Anti-thyroglobulin (TgAb) | Anti-thyroid peroxidase Antibody (TPOAb) | ||
| THYROID TBG ASSAY | |||
| Thyroxine Binding Globulin (TBG) | |||
| TISSUE DAMAGE ARRAY | |||
| Liver Fatty Acid Binding Protein-1 - FABP1 | Heart-Type Fatty Acid-Binding Protein - FABP3 | Adipose Fatty Acid Binding Protein - FABP4 | Epidermal Fatty Acid Binding Protein - FABP5 |
| Ileal Fatty Acid Binding Protein - FABP6 | Brain Fatty Acid Binding Protein - FABP7 | Testis Fatty Acid Binding Protein - FABP9 | |
| TUMOR PSA ARRAY | |||
| Free Prostate Specific Antigen (fPSA) | Total Prostate Specific Antigen (tPSA) | Carcinoembryonic Antigen (CEA) | |
| VITAMIN D ASSAY | |||
| Vitamin D |
| CARDIAC RISK PREDICTION | |||
| Target | SNP | Target | SNP |
| MIA3* | rs17465637 | LPA* | rs3798220 |
| 9p21 | rs10757274 | LPA* | rs10455872 |
| DAB2IP | rs7025486 | MRAS* | rs9818870 |
| CXCL12 | rs1746048 | LPL* | rs328 |
| ACE | rs4341 | LPL | rs1801177 |
| NOS3 | rs1799983 | SORT1*+ | rs646776+ |
| APOA5 | rs662799 | PCSK9 | rs11591147 |
| SMAD3 | rs17228212 | APOE* | rs429358 |
| APOB* | rs1042031 | APOE* | rs7412 |
| CETP | rs708272 | ||
| CHRONIC LUNG DISEASE (CLD) ARRAY | |||
| Viral | |||
| Adenovirus | Metapneumovirus | Respiratory syncytial virus A | Respiratory syncytial virus B |
| Rhinovirus A/B/C | Influenza virus A | Influenza virus B | |
| Bacterial | |||
| Achromobacter xylosoxidans | Bordetella pertussis | Burkholderia cepacia complex (21spp) | Burkholderia cenocepacia |
| Chlamydia pneumoniae | Haemophilus influenza | Moraxella catarrhalis | Mycoplasma pneumoniae |
| Non-tuberculous mycobacterium (15 spp) | Mycobacterium avium complex (4 spp) | Pandoraea species (5 spp) | Prevotella species (16 spp) |
| Pseudomonas aeruginosa | Staphylococcus aureus | Stenotrophomonas maltophilia | Streptococcus pneumoniae (21 spp) |
| Streptococcus species (19 spp) | Veillonella species (3 spp) | ||
| Fungal | |||
| Aspergillus fumigatus | Candida albicans | Exophialia dermatitidis | Scedosporium species (7 spp) |
| Antibiotic Resistance Markers | |||
| mecA (incl MRSA) |
| FAMILIAL HYPERCHOLESTEROLEMIA | |||
| LDLR 38 mutations | APOB 1 mutation | PCSK9 1 mutation | |
| APOB | PCSK9 | ||
| Mutation | Protein | Mutation | Protein |
| c.10580G>A | p.(Arg3527Gln) | c.1120G>T | p.(Asp374Tyr) |
| LDR | |||
| Mutation | Protein | Mutation | Protein |
| c.2292delA | p.(Ile764Metfs*2) | c.1187-10G>A | p.(=) |
| c.1444G>A | p.(Asp482Asn) | c.1048C>T | p.(Arg350*) |
| c.551G>A | p.(Cys184Tyr) | c.118delA | p.(Ile40Serfs*166) |
| c.1845+11C>G | p.(=) | c.1168A>T | p.(Lys390*) |
| c.693C>A | p.(Cys231*) | c.232C>T | p.(Arg78Cys) |
| c.933delA | p.(Glu312Serfs*58) | c.1587-1G>A | p.(=) |
| c.301G>A | p.(Glu101Lys) | c.1706-10G>A | p.(=) |
| c.313+1G>A | p.(=) | c.1796T>C | p.(Leu599Ser) |
| c.1706-1G>A | p.(=) | c.1436T>C | p.(Leu479Pro) |
| c.1706-1G>A | p.(Cys677Arg) | c.1474G>A | p.(Asp492Asn) |
| c.2029T>C | p.(Pro685Leu) | c.501C>A | p.(Cys167*) |
| c.2054C>T | p.(Trp483Arg) | c.662A>G | p.(Asp221Giy) |
| c.1447T>C | p.(Gly478Arg) | c.682G>T | p.(Glu228*) |
| c.1447T>C | p.(Asp72Thrfs*134) | c.1150C>T | p.(Gln384*) |
| c.214delG | p.(Trp87Gly) | c.938G>A | p.(Cys313Tyr) |
| c.259T>G | p.(Arg633Cys) | c.136T>G | p.(Cys46Gly) |
| c.1897C>T | p.(Asp227Glu) | c.2042G>C | p.(Cys681Ser) |
| c.681C>G | p.(Asn688Glnfs*29) | c.1618G>A | p.(Ala540Thr) |
| c.1285G>A | p.(Val429Met) | c.680_681delAC | p.(Asp227Glyfs*12) |
| KRAS, BRAF, PIK3CA ARRAY | |||
| KRAS Gene Targets | |||
| G12A | G12R | G12D | G12C |
| G12S | G12V | G13D | G13C |
| G13R | Q61K | Q61L | Q61R |
| Q61H(1) | Q61H(2) | A146T | A146P |
| BRAF Gene Targets | |||
| V600EG12R | |||
| PIK3CA Gene Targets | |||
| E542K | E545K | H1047R | |
| RESPIRATORY MULTIPLEX ARRAY II | |||
| Viral | |||
| Influenza A | Influenza B | Adenovirus A/B/C/D/E | Bocavirus 1/2/3 |
| Coronavirus 229E/NL63 | Coronavirus OC43/HKUI | Enterovirus A/B/C | Metapneumovirus |
| Parainfluenza virus 1 | Parainfluenza virus 2 | Parainfluenza virus 3 | Parainfluenza virus 4 |
| Respiratory syncytial virus A/B | Rhinovirus A/B/C | ||
| Bacterial | |||
| Legionella pneumophila | Bordetella pertussis | Chlamydophila pneumoniae | Haemophilus influenzae |
| Moraxella catarrhalis | Mycoplasma pneumoniae | Streptococcus pneumoniae |
| SEXUALLY TRANSMITTED INFECTION (STI) ARRAY | |||
| Pathogens | |||
| Chlamydia trachomatis (CT) | Neisseria gonorrhoea (NG) | Trichomonas vanginalis (TV) | Mycoplasma genitalium (MG) |
| Treponema pallidum (Syphilis) (TP) | Herpes simplex virus 1 (HSV-1) | Herpes simplex virus 2 (HSV-2) | Haemophilus ducreyi (HD) |
| Mycoplasma hominis (MH) | Ureaplasma urealyticum (UU) | ||
| URINARY TRACT INFECTION (UTI) ARRAY | |||
| Bacterial | |||
| Acinetobacter baumannii | Citrobacter freundii | Citrobacter koseri | Klebsiella aerogenes |
| Enterobacter cloacae | Enterococcus faecalis | Enterococcus faecium | Escherichia coli |
| Klebsiella oxytoca | Klebsiella pneumoniae | Morganella morganii | Proteus spp. |
| Pseudomonas aeruginosa | Providencia rettgeri | Providencia stuartii | Serratia marcescens |
| Staphylococcus aureus | Staphylococcus epidermidis | Staphylococcus saprophyticus | Streptococcus agalactiae (GBS) |
| Fungal | |||
| Candida albicans | |||
| Antibiotic Resistance Markers | |||
| mecA (incl MRSA) | Trimethoprim Resistance 1 | Trimethoprim Resistance 2 | Trimethoprim Resistance 3 |
| S mecA (incl MRSA) | Trimethoprim Resistance 4 | Trimethoprim Resistance 5 | Van A (Vancomycin Resistance A) |
| Van B (Vancomycin Resistance B) |