Randox Clinical Laboratory Services

Randox Clinical Laboratory Services (RCLS) specialises in offering esoteric biomarker testing utilising the expertise and knowledge Randox has built over 40 years producing high quality IVD diagnostics. RCLS strives to provide a clinical laboratory service to meet the time sensitive, bespoke requirements of research and clinical trial projects globally.

By utilising Randox Clinical Laboratory Services you can save your laboratory time and money. Our multiplex panels offer a cost effective, labour saving and time reducing solution for your sample testing. As a result, we provide your laboratory with the best solution for your sample testing.

Clinical laboratories traditionally perform diagnostic testing from a variety of patient samples (whole blood, serum, plasma, saliva, sputum, CSF, swab collections) to determine their health status.

In addition to Diagnostics, Randox Laboratories also perform Biomarker analysis from selected patient cohorts in support of pharma research, aiming at discovering a biological signal related to an NDE’s activity (targeted Biomarker approach) or a novel druggable target (proteomic analysis).  Randox Biosciences offer multiple technical solutions to address the above, mostly based on the Randox proprietary Biochip Array Technology.

  • Labs located at RCLS Science Park, Liverpool, Warrington & Dunstable
  • ISO17025 and ISO15189 accredited
  • LA Laboratory will open in Q2 2022 to run CLIA waved tests, with plans to be fully CAP certified by 2024
  • GCP certified for testing in clinical trials
  • Can be used for post approval sample analysis
  • Labs coming to LA, Glasgow, Cardiff, London & Dublin in 2022/2023

Sample & Data Management

 

– LIMS system (Labware) utilised and connected throughout the lab.

– Customer and project specific folders on an internal secure server

– Ability to transfer data securely through secure email/drop box

Capabilties

 

Randox Biosciences provide the building blocks of diagnostic development which includes antibodies, corresponding conjugates and proteins. Our immunoassay product offering provides diagnostic solutions covering a variety of disease areas including thyroid, reproduction, cardiovascular and renal.

Biochip Technology from Randox is an innovative assay technology which utilises multiplex testing methodology in a rapid, accurate and easy-to-use format, catering both molecular and immunoassay testing. The technology works by combining a panel of related assays in a single biochip with a single set of reagents, controls and calibrators. Only one single undivided sample is used. The results are read by a CCD-camera and custom image-processing software.

Custom Assay Development

 

Serving the diagnostic, pharmaceutical, contract research and biotech industries, Randox Biosciences dedicates custom unit develops and manufactures custom assay solutions. This also includes full customised quality control sera and calibrators. A selection of over 320 pre-qualified biomarkers is available for a custom panel design. However, any specific biomarker of interest will be considered for integration into an existing or desired panel, for technical feasibility (concentration range compatibility, potential interferences/cross-reactivities). The number of the required novel biomarkers will help make the feasibility study as a pertinent and complete as possible.

Companion Diagnostics (CDx) are part of the services that Randox Biosciences supply to pharmaceutical companies. With a long-recognized expertise in the development of esoteric assays, and more than 500 IVD products available globally, Randox is a partner of choice to support your CDx needs.

Full Assay Menu

  • Clinical
  • Molecular
AKI Array
Lipocalin (NGAL)ClusterinCystatin CKIM-1
ADHESION MOLECULES ARRAY
E-selectinP-selectinL-selectinICAM-1
VCAM-1
ANAEMIA ARRAY
FerritinFolateVitamin B12
ALZHEIMERS RISK ARRAY
Pan ApoEApoE4
CEREBRAL ARRAY II
sTNFRINGALNSED-dimer
CKD ARRAY I
EGFFABP1D-DimerIL-8
MIP-1 αsTNFRIsTNFRII
CKD ARRAY II
CYTOKINE ARRAY I
IL-1αIL-1βIL-2IL-4
IL-6IL-8IL-10IFNγ
EGFMCP-1TNFαVEGF
CYTOKINE ARRAY IV
MMP-9sIL-2RαsIL-6RsTNFRI
sTNFRII
CYTOKINE ARRAY V
IL-3IL-7IL-12p70IL-13
IL-23
FERTILITY ARRAY
Follicle Stimulating Hormone (FSH)Luteinising Hormone(LH)Prolactin Hormone (PRL)Progesterone (PROG)
Estradiol (EST)
GASTROPANEL ARRAY
Pepsinogen I (PGI)Pepsinogen II (PGII)Gastrin 17 (G17)
HELICOBACTER PYLORI ASSAY
Helicobacter Pylori (HP)
METABOLIC SYNDROME I ARRAY
FerritinIL-6InsulinLeptin
Plasminogen Activator Inhibitor-1 (PAI-1)ResistinTumour Necrosis Factor α (TNFα)
METABOLIC SYNDROME II ARRAY
AdiponectinC-reactive Protein (CRP)Cystatin C
PTH ASSAY
Parathyroid Hormone (PTH)
SHGB ASSAY
Sex Hormone-Binding Globulin (SHBG)
STROKE ARRAY
Soluble Tumour Necrosis FactorReceptor 1 (sTNFR1)Glial fibrillary acidic protein (GFAP)IL-6
Fatty acid binding protein 3 (FABP3)D-DimerParkinson Disease Protein 7 (PARK7)Nucleoside Diphosphate Kinase A
(NDKA)
Glutathione S-transferase, Pi (GSTP1)
TESTOSTERONE ASSAY
Testosterone
THYROID TOTAL ARRAY
Total thyroxine (TT4)Total tri-iodothyronine (TT3)Thyroid stimulating hormone (TSH)
THYROID FREE ARRAY
Free thyroxine (FT4)Free tri-iodothyronine (FT3)Thyroid stimulating hormone (TSH)
THYROID AUTO ANTIBODY ARRAY
Anti-thyroglobulin (TgAb)Anti-thyroid peroxidase Antibody (TPOAb)
THYROID TBG ASSAY
Thyroxine Binding Globulin (TBG)
TISSUE DAMAGE ARRAY
Liver Fatty Acid Binding
Protein-1 - FABP1
Heart-Type Fatty Acid-Binding
Protein - FABP3
Adipose Fatty Acid Binding
Protein - FABP4
Epidermal Fatty Acid Binding
Protein - FABP5
Ileal Fatty Acid Binding Protein - FABP6Brain Fatty Acid Binding
Protein - FABP7
Testis Fatty Acid Binding
Protein - FABP9
TUMOR PSA ARRAY
Free Prostate Specific Antigen (fPSA)Total Prostate Specific Antigen (tPSA)Carcinoembryonic Antigen (CEA)
VITAMIN D ASSAY
Vitamin D
CARDIAC RISK PREDICTION
TargetSNPTargetSNP
MIA3*rs17465637LPA*rs3798220
9p21rs10757274LPA*rs10455872
DAB2IPrs7025486MRAS*rs9818870
CXCL12rs1746048LPL*rs328
ACErs4341LPLrs1801177
NOS3rs1799983SORT1*+rs646776+
APOA5rs662799PCSK9rs11591147
SMAD3rs17228212APOE*rs429358
APOB*rs1042031APOE*rs7412
CETPrs708272
CHRONIC LUNG DISEASE (CLD) ARRAY
Viral
AdenovirusMetapneumovirusRespiratory syncytial virus ARespiratory syncytial virus B
Rhinovirus A/B/CInfluenza virus AInfluenza virus B
Bacterial
Achromobacter xylosoxidansBordetella pertussisBurkholderia cepacia complex (21spp)Burkholderia cenocepacia
Chlamydia pneumoniaeHaemophilus influenzaMoraxella catarrhalisMycoplasma pneumoniae
Non-tuberculous mycobacterium (15 spp)Mycobacterium avium complex (4 spp)Pandoraea species (5 spp)Prevotella species (16 spp)
Pseudomonas aeruginosaStaphylococcus aureusStenotrophomonas maltophiliaStreptococcus pneumoniae (21 spp)
Streptococcus species (19 spp)Veillonella species (3 spp)
Fungal
Aspergillus fumigatusCandida albicansExophialia dermatitidisScedosporium species (7 spp)
Antibiotic Resistance Markers
mecA (incl MRSA)
FAMILIAL HYPERCHOLESTEROLEMIA
LDLR 38 mutationsAPOB 1 mutationPCSK9 1 mutation
APOBPCSK9
MutationProteinMutationProtein
c.10580G>Ap.(Arg3527Gln)c.1120G>Tp.(Asp374Tyr)
LDR
MutationProteinMutationProtein
c.2292delAp.(Ile764Metfs*2)c.1187-10G>Ap.(=)
c.1444G>Ap.(Asp482Asn)c.1048C>Tp.(Arg350*)
c.551G>Ap.(Cys184Tyr)c.118delAp.(Ile40Serfs*166)
c.1845+11C>Gp.(=)c.1168A>Tp.(Lys390*)
c.693C>Ap.(Cys231*)c.232C>Tp.(Arg78Cys)
c.933delAp.(Glu312Serfs*58)c.1587-1G>Ap.(=)
c.301G>Ap.(Glu101Lys)c.1706-10G>Ap.(=)
c.313+1G>Ap.(=)c.1796T>Cp.(Leu599Ser)
c.1706-1G>Ap.(=)c.1436T>Cp.(Leu479Pro)
c.1706-1G>Ap.(Cys677Arg)c.1474G>Ap.(Asp492Asn)
c.2029T>Cp.(Pro685Leu)c.501C>Ap.(Cys167*)
c.2054C>Tp.(Trp483Arg)c.662A>Gp.(Asp221Giy)
c.1447T>Cp.(Gly478Arg)c.682G>Tp.(Glu228*)
c.1447T>Cp.(Asp72Thrfs*134)c.1150C>Tp.(Gln384*)
c.214delGp.(Trp87Gly)c.938G>Ap.(Cys313Tyr)
c.259T>Gp.(Arg633Cys)c.136T>Gp.(Cys46Gly)
c.1897C>Tp.(Asp227Glu)c.2042G>Cp.(Cys681Ser)
c.681C>Gp.(Asn688Glnfs*29)c.1618G>Ap.(Ala540Thr)
c.1285G>Ap.(Val429Met)c.680_681delACp.(Asp227Glyfs*12)
KRAS, BRAF, PIK3CA ARRAY
KRAS Gene Targets
G12AG12RG12DG12C
G12SG12VG13DG13C
G13RQ61KQ61LQ61R
Q61H(1)Q61H(2)A146TA146P
BRAF Gene Targets
V600EG12R
PIK3CA Gene Targets
E542KE545KH1047R
RESPIRATORY MULTIPLEX ARRAY II
Viral
Influenza AInfluenza BAdenovirus A/B/C/D/EBocavirus 1/2/3
Coronavirus 229E/NL63Coronavirus OC43/HKUIEnterovirus A/B/CMetapneumovirus
Parainfluenza virus 1Parainfluenza virus 2Parainfluenza virus 3Parainfluenza virus 4
Respiratory syncytial virus A/BRhinovirus A/B/C
Bacterial
Legionella pneumophilaBordetella pertussisChlamydophila pneumoniaeHaemophilus influenzae
Moraxella catarrhalisMycoplasma pneumoniaeStreptococcus pneumoniae
SEXUALLY TRANSMITTED INFECTION (STI) ARRAY
Pathogens
Chlamydia trachomatis (CT)Neisseria gonorrhoea (NG)Trichomonas vanginalis (TV)Mycoplasma genitalium (MG)
Treponema pallidum (Syphilis) (TP)Herpes simplex virus 1 (HSV-1)Herpes simplex virus 2 (HSV-2)Haemophilus ducreyi (HD)
Mycoplasma hominis (MH)Ureaplasma urealyticum (UU)
URINARY TRACT INFECTION (UTI) ARRAY
Bacterial
Acinetobacter baumanniiCitrobacter freundiiCitrobacter koseriKlebsiella aerogenes
Enterobacter cloacaeEnterococcus faecalisEnterococcus faeciumEscherichia coli
Klebsiella oxytocaKlebsiella pneumoniaeMorganella morganiiProteus spp.
Pseudomonas aeruginosaProvidencia rettgeriProvidencia stuartiiSerratia marcescens
Staphylococcus aureusStaphylococcus epidermidisStaphylococcus saprophyticusStreptococcus agalactiae (GBS)
Fungal
Candida albicans
Antibiotic Resistance Markers
mecA (incl MRSA)Trimethoprim Resistance 1Trimethoprim Resistance 2Trimethoprim Resistance 3
S mecA (incl MRSA)Trimethoprim Resistance 4Trimethoprim Resistance 5Van A (Vancomycin Resistance A)
Van B (Vancomycin Resistance B)
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