Superoxide Dismutase (Ransod)
Benefits of the Randox Ransod Assay
A correlation coefficient of r=0.965 was displayed when the Randox Ransod assay was compared against commercially available methods.
The Randox Ransod assay displayed a within run precision of <4.65% CV.
Excellent measuring range
The Randox Ransod assay has a measuring range of 0.00 – 5.50 U/ml for the comfortable detection of clinically important results.
Standard included in kit
The standard is supplied with the Ransod kit, simplifying the ordering process.
Dedicated Ransod control available
A dedicated Ransod control is available offering a complete testing package.
Applications available detailing instrument-specific settings for the convenient use of the Randox Ransod assay on a variety of clinical chemistry analysers.
Superoxide dismutase (SOD) are a group of metalloenzymes, the first line of defence against reactive oxygen species (ROS)-medicated injury. SOD is responsible for catalysing the dismutation of the superoxide anion free radical (O2–) into molecular oxygen and hydrogen peroxide (H2O2). The aim of this process is to reduce the levels of O2– as it damages cells at excessive concentrations 1.
SOD is the most important antioxidant defence against oxidative stress. SOD is a severe anti-inflammatory agent and can prevent precancerous cell changes. Reduced SOD levels have been observed in older generations as SOD levels drop as the body ages and so are more prone to oxidative related diseases. Reduced SOD activity has been identified as having a strong correlation with Alzheimer’s Disease. The overexpression of SOD-2 reduces hippocampal superoxide, preventing memory defects 1. Moreover, SOD has been identified as a potential diagnostic and prognostic marker in patients with gastric cancer 2. SOD has also been linked to other health conditions, including: rheumatoid arthritis, RBC-related disorders, Crohn’s Disease, cystic fibrosis, malignant breast cancer and neuronal apoptosis 1, 3.
Fig. 1. Pathological effects associated with SOD gene mutation or SOD deficiency 4
Reagents Resource Hub
 Li J, Lei J, He L, Fan X, Yi F, et al. Evaluation and Monitoring of Superoxide Dismutase (SOD) Activity and its Clinical Significance in Gastric Cancer: A Systematic Review and Meta-Analysis. Medical Science Monitor 2019; 19(25): 2032-2042.
 Marrocco I, Altieri F, Peluso I. Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans. Oxidative Medicine and Cellular Longevity 2017; 2017(6501046): 1-32. http://downloads.hindawi.com/journals/omcl/2017/6501046.pdf (accessed 25 February 2020).
 Ighodaro OM, Akinloye. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria Journal of Medicine 2018; 54(4): 287-293.