Cardiac Risk

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CVD

Your heart is amazing. Not only is it your most critical organ but also one of the most hard-working. The average adult heart beats around 100,000 times a day, acting as a giant pump for all the blood in your body. Indeed, every day your heart pumps over nine litres of blood through a system of blood vessels over 60,000 miles long – it’s little wonder, then, the importance placed on looking after such a vital muscle.

Did you know?

Cardiovascular Diseases (CVDs) are the number 1 cause of death globally, more people die annually from CVDs than any other cause.

 

Over time, and influenced by lifestyle choices, the heart grows weaker, needing to work harder to fulfil its function. Crucial lifestyle changes now could limit your risk of developing serious cardiac conditions, such as Cardiovascular Disease (CVD) in the future.

While lifestyle changes may help to limit your risk of CVD, and related heart condition, it is impossible to eradicate it completely for everyone. Cardiovascular disease is the number one cause of death globally. Across the world, 17.7 million people died from CVDs in 2015. In the UK, it accounts for nearly one death around every eight minutes.

But early screening and improved access to cutting-edge diagnostics could lower this figure significantly. According to the WHO there are 8 key risk factors of developing CVD and they account for as much as 61% of all cardiovascular deaths, these include;

Smoking

The harmful substances in tobacco can damage and narrow blood vessels, causing CVDs. Smoking kills approximately half of persistent smokers, around 14% of deaths from circulatory disease can be attributed to smoking.

High Blood Pressure

High blood pressure (hypertension) is one of the most important risk factors of CVD, if your blood pressure is too high your blood vessels can become damaged.

High BMI

Being overweight or obese increases the risk of developing diabetes and high blood pressure, both of which can cause CVD. You’re at an increased risk of CVD if your BMI is 25 or above.

High Cholesterol

Cholesterol is a fatty substance found in the blood, high levels of cholesterol can cause blood vessels to narrow and increase the risk of developing a blood clot. Reducing the populations LDL-Cholesterol by 5% would prevent 64,000 cases of CVD.

Lack of Physical Activity

If you don’t exercise regularly, it’s more likely you’ll develop high blood pressure, high cholesterol levels and become overweight. All of which are risk factors of CVD. Exercising regularly helps to keep the heart healthy.

Other CVD risk factors include an excessive alcohol intake, an unhealthy diet and high levels of blood glucose.

Related Products 

Randox has developed the RX series of clinical chemistry analysers for superior semi-automated and fully automated testing. The RX series extensive dedicated test menu goes beyond routine testing and has many unique and high-performance tests available. Our range of tests covers many tests for the diagnosis and monitoring of cardiac diseases.

Cardiac Panel

CholesterolCRP Full Range(0.3-160mg/l)Direct LDL CholesterolsLDL
CK-MBCRP High SensitivityHeart-Type Fatty Acid Binding Protein (H-FABP)Triglycerides
CK-NACDigoxinLipoprotein(a)TxB Cardio
CRPDirect HDL CholesterolMyoglobinAdiponectin

 

Our world leading test menu of high quality reagents guarantees excellence in patient care ensuring unrivalled precision and accuracy reducing costly test re-runs or misdiagnosis and offering complete confidence in results.

The RX series clinical chemistry analysers provide laboratories with a robust and smart solution ensuring you maintain a consistent workflow and can provide accurate results first time, every time. Offering excellent customer support services, our trained engineers are on hand to work with you in preserving the continuity of your operations while maximising the potential of your RX series instrument.

For more information visit: https://www.randox.com/clinical-chemistry-analysers/

Cardiac health and regular cardiovascular screening is important to enable risk factors to be detected in their earliest stages. Randox reagents offer a comprehensive cardiology product profile which includes high performance reagents for the detection of conventional risk factors, as well as emerging biomarkers associated with further risk.

sLDL cholesterol

sLDL cholesterol  is a vital cardiac risk marker which utilises the “Denka Seiken” method which produces results in less than ten minutes. Research has shown individuals with a predominance of sLDL have a 3-fold increased risk of myocardial infarction (MI), even for those who HDL, LDL, Total Cholesterol and Triglyceride levels are considered ‘normal’. Elevated levels of sLDL are associated with a sedentary lifestyle, a diet high in saturated fat, insulin resistance, pre-diabetes and genetic disposition. Measurement of sLDL allows the clinician to get a more comprehensive picture of lipid risk factors and tailor treatment accordingly. Reducing LDL levels reduce the risk of both CVD and MI.

For more information visit: www.randox.com/sldl-cholesterol/

Lipoprotein (a)

Lipoprotein (a) is a major independent genetic risk factor for premature CVD and elevated levels can occur in patients with otherwise normal lipid levels, therefore providing much needed information in relation to a patient’s risk of developing CVD.Along with other tests, Lp(a) can provide additional information on a patient’s risk factor of developing cardiovascular disease (CVD).

The Randox Lp(a) assay is one of the only methodologies on the market that detects the non-variable part of the Lp(a) molecule and therefore suffers minimal size related bias providing more accurate and consistent results.

For more information visit: www.randox.com/lipoprotein-a/

Adiponectin

Randox Adiponectin is a liquid ready-to-use automated biochemistry reagents offering a new and exciting technique for adiponectin measurement, which moves away from often time-consuming ELISA products. Adiponectin is solely excreted by adipocytes and is a protein hormone with anti-inflammatory and insulin sensitising properties. It plays an important role in a number of metabolic processes such as glucose regulation and fatty acid oxidation.

Adiponectin levels are inversely correlated with abdominal visceral fat (AVF) levels, which have proven to be a strong predictor of several pathologies including cardiovascular disease, type 2 diabetes, metabolic syndrome and cancer.

For more information visit: www.randox.com/adiponectin/

HDL3 Cholesterol

HDL3 Cholesterol is a smaller and more dense sub fraction of the HDL particle. HDL comprises of several subclass particles, which differ in their sizes, densities and components. HDL is the scavenger of cholesterol within arterial walls and the levels of HDL3 is too low, the ability to remove this cholesterol is reduced. Therefore, it is widely accepted that there is an inverse correlation between HDL3 and cardiovascular disease risk.

For more information visit: https://www.randox.com/hdl3/

 

Cardiology and Lipid Testing Panel

  • Adiponectin
  • Apolipoprotein A-I
  • Apolipoprotein A-II
  • Apolipoprotein B
  • Apolipoprotein C-II
  • Apolipoprotein C-III
  • Apolipoprotein E
  • Cholesterol (sLDL)
  • Cholesterol (HDL)
  • Cholesterol (LDL)
  • Cholesterol (Total)
  • Cholesterol (HDL3)
  • Lipoprotein (a)
  • High sensitivity CRP
  • Homocysteine
  • Triglycerides
  • HDL3-C
  • sPLA₂-IIA
  • Heart Type Fatty Acid Binding Protein (H-FABP)
  • CK-MB
  • Myoglobin
  • Digoxin
  • TxBCardio™

Browse our full cardiology and lipid testing panel here.

To request an application for your specific analyser, contact us at reagents@randox.com

When diagnosing and monitoring CVD, it is vital that laboratories have a robust Quality Control (QC) system in place to ensure the accuracy and reliability of the results produced. The Acusera Cardiac Controls have been designed to cover a wide range of cardiac markers at clinical decision levels eliminating the need for additional low level controls at extra expense. Available in both liquid ready-to-use and lyophilised formats, they are ideal for use at the point-of-care and in the laboratory. Manufactured from 100% human serum a matrix similar to that of the patient is guaranteed.

Liquid Cardiac Control

  • Liquid ready-to-use
  • 100% human serum
  • Assayed target values provided for 8 cardiac markers
  • Cut off levels for Troponin I and T in line with internationally recommended levels
  • Stable to expiry date at 2°C – 8°C
  • Open vial stability of 30 days at 2°C – 8°C for all analytes

Analytes

MyoglobinTroponin ITroponin T
NT – ProBNPCK-MB (Mass)D-dimer
DigoxinhsCRP

Find out more about our Liquid Cardiac Quality Control here.

Other cardiac quality controls include:

For more information, visit our Cardiac Quality Controls page.

RIQAS Cardiac Programme

The RIQAS Cardiac EQA programme is designed to monitor the performance of up to 7 clinically significant cardiac markers. Two flexible reporting options are available to suit the needs of all laboratory sizes.

  • Accredited to ISO/IEC 17043
  • Lyophilised for enhanced stability
  • 100% human serum
  • Bi-weekly reporting
  • Submit results and view reports online via RIQAS.Net
  • Register up to five instruments at no extra cost

For more information, visit our RIQAS Cardiac Programme page.

Our Randox Health clinics offer comprehensive health testing as part of our Signature, Everyman and Everywoman packages to identify and assess risk of developing Cardiovascular Disease. Our clinics utilise the same cutting-edge tests and quality control that we have available to clinical laboratories globally, as well as our patented Biochip Array Technology (BAT).

For more information visit: https://www.randoxhealth.com/

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