sdLDL Cholesterol Reagent

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sdLDL-C

Key benefits of the Randox sdLDL-C reagent

Exceptional correlation with the gold standard method

The Randox methodology was compared against the gold standard method, ultracentrifugation, and the Randox sdLDL-C reagent showed a correlation coefficient of r=0.99

Randox sdLDL-C utilizes the “Denka Seiken” method

The “Denka Seiken” method produces results in as little as ten minutes, facilitating faster patient diagnosis and treatment plan implementation. Previously, ultracentrifugation and electrophoresis based methods were options for the measurement of sdLDL cholesterol, which are both laborious and time consuming

Wide measuring range

The healthy upper limit for sdLDL-C is 4.90mmol/l.  The Randox sdLDL-C assay can comfortably detect levels outside of the healthy range, measuring between 4 – 100 mg/dl

Other features of the Randox sdLDL-C reagent

  • Denka Seiken method
  • Liquid ready-to-use reagents
  • Correlation coefficient of r=0.99 with Ultracentrifugation method
  • Stable to expiry when stored at +2 to +8°C
  • Measuring range 4 – 100 mg/dl

 

Cat NoSizeAnalyserEasy Read
Easy Fit
 
562616R1 1 x 19.8ml
R2 1 x 8.6ml
RX Daytona/Imola

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the sdLDL-C assay used for?

Clinical Significance of sdLDL-C

There are two main types of LDL cholesterol which vary in size through genetic determination and dietary lipid intake, ranging from small and dense to large and buoyant LDL.  All LDL cholesterol transports triglycerides and cholesterol to bodily tissues, however, their atherogenesis varies according to their size.  Smaller particles like sdLDL-C can more readily permeate the arterial wall and are more susceptible to oxidation.

sdLDL-C in clinical practice

Extend your lipid profile

sdLDL measurement is an extremely valuable lipid as it is a vital risk marker for the detection of myocardial infarction.  Research indicates that individuals with a predominance of sdLDL-C have a three-fold increased risk of myocardial infarction. Elevated levels of sdLDL-C are caused by a diet high in saturated fat’ a sedentary lifestyle, insulin resistance, prediabetes and genetic deposition.  Measurement of sdLDL-C enables the clinician to gain a comprehensive overview of lipid risk factors and to tailor treatment accordingly. For more information on the low-density lipoprotein subclass patterns and myocardial infarction, click here [external link].

Check out the Randox sdLDL-C Whitepaper

sdLDL-C
  • Moloney, F., et al. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus 1,2,3. Am. J. Clin. Nutr. 2004, 80(4): 887-895
  • Nowak, M., et al. Changes in lipid metabolism in women with age-related macular degeneration. Clin. Exp. Med., 2005, 4(4): 183-187
  • Chen, C-W and Cheng, H-H. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J. Nutr. 2006, 136: 1472-1476
  • Moreira Lima, L., et al. Níveis Plasmàticos Elevados de Lipoproteína(a) Correlacionados com a Gravidade da Doenca Arterial Coronariana em Pacientes Submetidos à Angiografia (Increased Serum Levels of Lipoprotein(a) Correlated with the Severity of Coronary Artery Disease in Patients Submitted to Angiography. Arquivos Brasileiros de Cardiologia. 2006, 87(3): 260-266
  • Chou T-W., et al. A Rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced Type 2 diabetes. J.Clin. Biochem.Nutr. 2009, 45(1): 29-36
  • Rhodes, P., et al. Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PloS ONE 2009, 4(10): e7393
  • Wonnacott, K.E. et al. Dietary omega-3 and-6 polyunsaturated fatty acids affect the composition and development of sheep granulose cells, oocytes and embryos. Reproduction. 2010, 139(1): 57-69
  • Ganguli, D., et al. Association between inflammatory markers and cardiovascular risk factors in women from Kolkata, W.B, India. Arq. Bras. Cardiol. 2011, 96(1): Epub
  • Srinivasa, G., et al. Comparison between serum insulin levels and its resistance with biochemical, clinical and anthropometric parameters in South Indian children and adolescents. Ind. J. Biochem. 2011, 26(1): 22-27
  • Yahaya, N. et al. Type 2 diabetes with good glycemic control have improved insulin response and lower non-esterified fatty acid level after a meal challenge. Journal of Diabetes Mellitus 2012, 2(1): 1-7

Cardiology Panel

For more information or to view more reagents within the cardiology panel, please click here

Lipid Panel

For more information or to view more reagents within the lipid panel, please click here

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