Aspartate Aminotransferase (AST) Reagent

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Key Benefits of the Aspartate Aminotransferase (AST) reagent

Wide measuring range

The upper healthy limit for AST is 37 U/l. The Randox Aspartate Aminotransferase (AST) assay can comfortably detect levels outside of the healthy range, measuring from 4.42 – 657 U/l.

Excellent stability

Stable until expiry date when stored at +2 to +8°C

Liquid ready-to-use reagents

The Randox AST reagent comes in a liquid format which is more convenient as the reagent does not need to be reconstituted which aids in reducing the risk of errors occurring

Other features of the Aspartate Aminotransferase (AST) reagent

  • UV (Modified IFCC)
  • Liquid and lyophilised reagents available
  • Stable until expiry date when stored at +2 to +8°C
  • Measuring range 4.42 – 657 U/l
Cat NoSizeAnalyserEasy Read
Easy Fit
 
(L) Indicates liquid option (S) Indicates standard included in kit
AS120220 x 2mlGeneral Use--
AS120410 x 10mlGeneral Use--
AS12675 x 20mlGeneral Use--
AS23595 x 100mlGeneral Use--
AS38766 x 20mlRX Daytona/Imola
Hitachi 717/911/912/704/902


AS7938R1 7 x 100ml (L)
R2 3 x 60ml
Hitachi 717/911/912/704/902
RX Daytona/Imola


AS3804R1 6 x 51ml (L)
R2 6 x 14ml
RX Daytona/Imola
Hitachi 717/911/912/704/902


AS101R1 1 x 100ml (L)
R2 1 x 100ml (Colorimetric, manual only)
Manual Only--
AS1472 x 100ml (S) (L)
(Colorimetric, manual only)
Manual Only--
AS8005R1 6 x 56ml (L)
R2 6 x 20ml
RX Suzuka
Abbott Architect
Hitachi 917/Mod P
BS120/200/300/400
Konelab 20i/30i/60i
Beckman Coulter AU Series










AS8306R1 4 x 20ml (L)
R2 4 x 7ml
RX Daytona +/Monaco
Abbott Architect
Hitachi 917/Mod P
BS120/200/300/400
Konelab 20i/30i/60i
Beckman Coulter AU Series










Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the Aspartate Aminotransferase (AST) assay used for?

What is AST?

Aspartate Aminotransferase (AST), formerly known as serum glutamic oxaloacetic transaminase (GOT) is an enzyme found throughout the body.  The high concentration levels of AST are found in the liver and lower concentration levels are found in heart cells, red blood cells, muscle tissues and other organs including the kidneys and pancreas.

What is the AST assay used for?

Elevated concentrations levels of AST in the blood are directly correlated to the severity of the tissue or organ damage and can signal myocardial infarction, hepatic disease, muscular dystrophy and organ damage.  Excessive levels (10 times above the normal range) is indicative of liver damage including acetaminophen overdose, acute viral hepatitis or acute fulminant hepatitis, and tumor necrosis.  Moderately high concentration levels of AST are indicative of alcohol abuse, hemolysis, heart damage including heart attack or heart failure, muscle injury including trauma or muscle dystrophy.  Slightly elevated concentration levels of AST are indicative of cirrhosis, fatty change in the liver or mononucleosis.

The Randox AST assay is used for the quantitative in vitro determination of aspartate aminotransferase (AST) activity in serum and plasma.

AST often tested in combination with the alanine aminotransferase (ALT) test as part of the hepatic panel as ALT concentration levels are higher in most types of liver disease.  For more information on the validity and clinical utility of AST and ALT when assessing disease severity, please click here [external link].

  • Mula-Abed, W-A. S. and Hanna, B.E. Measurement of serum fructosamine as an index of glycated protein in patients with nephrotic syndrome and chronic liver diseases. Bahrain Medical Bulletin 2001, 23(4).
  • Oyejide, O.O. and Olushola, L. Hepatoprotective and antioxidant properties of extract of Carmellia sinensis (black tea) in rats. African Journal of Biotechnology 2005, 4(11): 1432-1438.
  • Saad, S.Y. et al. Cardiotoxic effects of arsenic trioxide/imatinib mesilate combination in rats. J. Pharm. Pharmacol. 2006, 58(4): 567-573.
  • Saad, S.Y. et al. Cardioprotective effects of subcutaneous ebselen against daunorubicin-induced cardiomyopathy in rats. Basic Clin. Pharmacol. Toxicol. 2006, 99(6): 412-417.
  • Akpanabiatu, M.I., et al. Effects of interaction of vitamin A and Rauwolfia vomitoria root bark extract on marker enzymes of cardiac diseases. Indian Journal of Clinical Biochemistry. 2009, 24(3): 241-244.
  • Suanarunsawat, T. et al. Antioxidant activity and lipid-lowering effect of essential oils extracted from Ocimum sanctum L. leaves in rats fed with high cholesterol diet. J. Clin. Biochem. Nutr. 2010, 46(1): 52-59.
  • Awe, S. and Olayinka E.T. Effect of cashew wine on histology and enzyme activities of rat liver. J. Toxicol. Environ. Health Sci. 2011, 3(2): 31-38.
  • Iribhogbe, O.I., et al. Effects of vitamins A, C and E on liver function in pregnancy. Asian Journal of Medical Sciences. 2011, 3(1): 8-13.

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