The Randox range of antioxidant reagents are designed for use within a variety of sectors including clinical, research, veterinary, pharma, food and beverages, cosmetics and sports. Our range of antioxidant reagents include routine antioxidant reagents as well as specialised tests unique to Randox.
Randox antioxidants are available in liquid and lyophilised formats
A variety of kits, methods and ranges are available
Complementary controls and calibrators are available
Suitable for a wide variety of sample types, including whole blood (human and animal), serum, plasma, erythrocytes, wine, beer and fruit juice
Suitable for automation which removes the inconvenience and time consumption associated with traditional ELISA based testing options
Instrument Specific Applications (ISA’s) are available for an extensive range of clinical chemistry analysers which includes detailed instrument specific settings for increased convenience.
The body’s antioxidant defence system
The body’s antioxidant defence system is made up of antioxidants produced by the body naturally, in addition to requiring external sources to obtain antioxidants it cannot produce. The best source of antioxidants includes antioxidant rich foods. Foods high in antioxidants include fruits, vegetables and grains. The body’s natural antioxidant production declines with age, and therefore an antioxidant rich diet is important to ensure a healthy you.
The Role of Antioxidants
Antioxidants are important for the body’s immune system and to protect the body against free radical attacks. Randox provides a range of antioxidant reagents to assess all three levels of the body’s defence system (preventative antioxidants, scavenging antioxidants and repair enzymes).
- Preventative antioxidants – Inhibit the formation of free radicals including metal binding proteins like; Ceruloplasmin, Metallothionine, Albumin, Transferrin, Ferritin and Myoglobin
- Scavenging antioxidants – Remove any reactive species once formed. such as Superoxide Dismutase, Glutathione Peroxidase, Catalase and small molecules including Ascorbate, Tocopherol, Bilirubin, Uric Acid, Carotenoids and Flavonoids
- Repair enzymes – Repair damaged biomolecules such as DNA repair enzymes
Free radical damage
Free radicals are highly reactive cells produced during the process of oxidation, a reaction which takes place during many of the body’s natural key processes such as respiration. Free radicals may also be produced when there is inflammation in the body, during exercise, as well as the body responding to environmental factors such as sunlight and pollutants (chemicals, cigarette smoke etc.).
Antioxidants typically inhibit the formation of free radicals, destroy free radicals, or repair damaged cells. However if antioxidants are unavailable or if oxidative stress occurs, damage to the surrounding cells or tissue can occur. The term oxidative stress refers to the imbalance between the production of free radicals and the body’s ability to detoxify them i.e. when there is an excessive production of free radicals. As a result, free radicals have been implicated in many disease states.
Antioxidant benefits against disease
Free radicals have been found to play a role in the development of many diseases including cancer (free radicals are thought to promote cell transformation into a cancer cell), arthritis and inflammatory diseases (increased oxidative stress in rheumatoid arthritis patients suggests antioxidants could have an important role), cardiovascular disease (antioxidants have been found to improve cardiac health), and Alzheimer’s disease (antioxidants have a role in removing deleterious free radicals from the brain).
Total Antioxidant Status (TAS) is a test used for a general overview of the antioxidants in a patient’s body.
Glutathione Peroxidase (Ransel) accurately measures selenium levels and is a test used to ensure a patient has the correct antioxidants required to protect the body from oxidative damage, and destroy free radicals that have formed in the body. If selenium levels are too low it can cause a loss of protection against serious illness, and if they are too high they can be toxic to a patient.
Superoxide Dismutase (Ransod) measures a patient’s level of superoxide which is a free radical which plays a vital role in the ageing process.