D-3 Hydroxybutyrate (Ranbut)

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Key Benefits

Excellent precision

The Ranbut assay showed a precision of less than 3.5% CV

Exceptional correlation

The assay showed a correlation of r=1.00 against another commercially available method

Wide measuring range

The Randox Ranbut assay has a wide measuring range of 0.100 – 5.75 mmol/l, capable of detecting abnormal levels in a sample

Randox D-3 Hydroxybutyrate (Ranbut)

  • Enzymatic method
  • Lyophilised reagents
  • Reconstituted stability of 7 days at 2-8⁰C
  • Measuring range 0.100 – 5.75 mmol/l
Cat NoSizeAnalyserEasy Read
Easy Fit
 
(S) Indicates standard included in kit
RB100710 x 10ml (S)General Use--
RB100810 x 50ml (S)General Use--

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is D-3 Hydroxybutyrate (Ranbut) assay used for?

D-3 Hydroxybutyrate is the major ketone body in the blood. The nitroprusside method of ketone detection, used in semi-quantitative dipstick tests detects acetone and acetoacetate, but not D-3 Hydroxybutyrate. During ketosis, D-3 Hydroxybutyrate levels increase more than the levels of acetone and acetoacetate, making D-3 Hydroxybutyrate a more sensitive marker of ketosis. D-3 Hydroxybutyrate is the most stable of the ketone bodies (7 days at +4⁰c) – acetone and acetoacetate are unstable, so serious errors can arise if analysis is delayed. D-3 Hydroxybutyrate can be used for the detection of ketosis is important in a number of conditions:

  • Diabetic ketosis
  • Alcoholic ketosis
  • Severe injury, illness or sepsis
  • Dieting
  • Childhood epilepsy
  • Ketotic hypoglycaemia
  • Nishina, H., et al. Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep. J. Physiol. 2003, 553(2): 637-647
  • Graaf-Roelfsema, E. et al. Effects of short -and long-term recombinant equine growth hormone and short-term hydrocortisone administration on tissue sensitivity to insuline in horses. American Journal of Veterinary Research. 2005, 66(11): 1907-1913
  • Miyashita, M., et al. Exercise and postpandrial lipemia: effect of continuous compared with intermittent activity patterns. Am. J. Clin. Nutr. 2006, 83(1): 24-29
  • Geddes J., et al. Cardiac troponin I concentrations in people presenting with diabetic ketoacidosis. Ann. Clin. Biochem. 2007, 44(4): 391-393
  • Li, L., et al. LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signalling. Am. J. Physiol. Endocrinol. Metab. 2007, 293: E587-E594
  • Sinclair, L.A., et al. Effect of rate of substitution of processed, urea-treated whole-crop wheat for grass silage on the intake, milk production and diet digestibility in dairy cows and ruminal metabolism in vitro. Animal. 2007, 1: 601-611
  • Wathes, D.C., et al. Differences between primiparous and multiparous dairy cows in the inter-relationships between metabolic traits, milk yield and body condition score in the periparturient period. Domestic Animal Endocrinology. 2007, 33(2): 203-225
  • Begriche. K., et al. Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice. Am. J. Physiol Endocrinol Metab. 2008, 294: E939-E951
  • Keogh, J.B., et al. Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity1, 2, 3. Am. J. Clin. Nutr. 2008, 87(3): 567-576
  • Nylen, K., et al. A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype. Exp. Neurol. 2008, 210(2): 449-457
  • Bruce, K.D., et al. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology. 2009, 50(6): 1796-1808
  • Freemantle, E. et al. Metabolic response to ketogenic breakfast in the healthy elderly. J. Nutr. Health Aging 2009, 13(4): 293-298
  • Kalmus P., et al. Effect of yeast culture on milk production and metabolic reproductive performance of early lactation dairy cows. Acta Veterinaria Scandinavica. 2009, 51: 32
  • Marton A., et al. Milk progesterone profiles, blood metabolites, metabolic hormones and pregnancy rates in Awassi ewes treated by gestagen + eCG at the early breeding season. Veterinarni Medicina, 2009, 54: 507-516
  • Tremblay-Mercier, J. et al. Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects. J. Pharmacol. Exp. Ther. 2010, 334(1): 341-346
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