Lipid Reagents

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Lipid tests are used to assess an individual’s risk of heart attack or stroke. As the most important of the cardiac risk tests they provide a good, clear indication of whether someone is likely to have a coronary event caused by a blockage of the blood vessels or atherosclerosis (narrowing of the arteries caused by build-up of fatty deposits). A complete lipid profile involves routine tests such as Total Cholesterol, Triglycerides, HDL Cholesterol and LDL Cholesterol to measure the levels of triglycerides and cholesterol in the blood. In addition we also offer an extended lipid profile and assays measuring emerging risk factors of cardiovascular disease (CVD).

To discover more about our range of lipid assays select an option from the drop-down menu. Alternatively, read on to gain an understanding of lipids and the relevancy of Randox lipid assays.

Lipid products available from Randox

Cardiovascular disease is the number 1 cause of death globally (WHO, 2015)!

Cardiovascular disease occurs as a result of reduced blood flow to the heart, brain or body and includes coronary heart disease, cerebrovascular disease and peripheral arterial disease (diseases of the blood vessels supplying the heart, brain and arms and legs). Reduced blood flow may be a result of a blood clot or due to a build-up of fatty acids in the arteries causing them to narrow. This can result in a heart attack or stroke.

Lipid tests are vital in the risk assessment of cardiovascular disease…

Lipid tests aim to assess the risk of cardiovascular disease by screening for abnormalities of triglyceride and cholesterol levels in the blood. Triglycerides and cholesterol are types of fat in the blood. Triglycerides, the main constituent of body fat, is produced by the liver as well as obtained through diet (meats, dairy produce and cooking oils). Cholesterol is a fat-like substance found in all cells of the body and is produced by the liver for use by the body; its uses include making hormones, vitamin D, and substances that assist in food digestion. Triglycerides and cholesterol contribute to the build-up of fatty deposits, and thus lipid profiling enables preventative measures to be taken to maintain safe levels and reduce the chances of cardiovascular disease.

Ask your doctor to assess your lipids profile!

If you are worried about your cardiovascular health ask your doctor to assess your lipids profile. Routine tests include a Total Cholesterol test assessing overall cholesterol levels, a HDL Cholesterol test to measure the level of ‘good cholesterol’ in the blood, an LDL Cholesterol test to measure the level of ‘bad cholesterol’ in the blood, and a Triglycerides test assessing triglyceride levels (of which high levels are associated with increased risk of developing cardiovascular disease).

Be sure to mention extended tests!

In addition to routine tests, Randox offers a range of extra tests for extended analysis of blood lipids and emerging risk factors.

Our extended lipids profile includes the measurement of lipoproteins, proteins in the blood which enable triglycerides, cholesterol and other fats to move to appropriate cells. Measurement of this allows understanding as to why abnormal lipid levels may be occurring:

  • Apolipoprotein A-I (removes excess cholesterol from extra-hepatic tissues) test is used to find the cause of high lipid levels and discover if a disorder is causing Apo A-I deficiency
  • Apolipoprotein B (the main protein in LDL cholesterol aka ‘bad cholesterol’) test is used as an extended risk assessment of cardiovascular disease; elevated levels indicate increased risk even when total and LDL cholesterol levels are normal
  • Both tests are useful for those with a personal or family history of high concentrations of lipids and/or heart disease, to help diagnose conditions causing elevated lipid levels, and, to measure the effectiveness of lipid lowering treatments

Analysis of emerging risk factors also contributes to risk assessment of cardiovascular disease:

  • Lipoprotein (a) levels are genetically determined and remain fairly constant as they are not affected by lifestyle factors such as diet. High levels can occur in individuals with an otherwise normal lipid profile and can increase risk of cardiovascular disease. It is recommended that patients who have developed cardiovascular disease at a young age or those with a family history of premature heart disease be tested
  • sLDL Cholesterol, a subtype of LDL Cholesterol aka ‘bad cholesterol’ is a vital marker for heart attack; elevated levels are associated with a three-fold increased risk of heart attack

Lipid profiling plays a vital role in preventative healthcare…

Cardiovascular disease (CVD), the leading cause of death globally, puts increased strain on the healthcare industry and can be prevented by addressing the risk factors associated. Lipid profiling enables this by assessing a patient’s risk of CVD. As the most important tests in cardiac risk assessment, lipids measure the level of triglycerides and cholesterol in the blood; thus detecting abnormal levels enabling lifestyle changes to be made, or medical treatment if necessary.

Such actions prevent atherosclerosis (build-up of fatty deposits in the arteries) and diseases such as coronary heart disease, cerebrovascular disease and peripheral arterial disease which can lead to myocardial infarction (MI) or stroke.  Early intervention allows patients time to change their behaviours before it is too late.

Go the extra mile for your patients with our extended lipid profile!

In addition to the conventional lipid profile Total Cholesterol, HDL Cholesterol, LDL Cholesterol and Triglycerides, we also have extended tests which can provide extra information on a patient’s lipid profile. This includes measurement of lipoproteins and their counterparts, apolipoproteins, which have the role of transferring triglycerides, cholesterol and other fats to appropriate cells for metabolism. Measurement of these allows investigation into why abnormal lipid levels may be occurring. Our extended lipids profile consists of the following tests:

  • Apolipoprotein A-I, responsible for removing excess cholesterol from extra-hepatic tissues and has an inverse relationship to CVD; this test is used to find the cause of high lipid levels and detect if abnormal levels are due to a disorder causing Apo-A I deficiency
  • Apolipoprotein B, the main protein in LDL cholesterol (‘bad cholesterol’) is the ligand concerned with the uptake of cholesterol; elevated levels indicate increased risk of CVD even when total and LDL cholesterol levels are normal
  • Apo A-I and Apo B are useful to assess patients with a personal or family history of high concentrations of lipids and/or heart diseases, for diagnosis of conditions causing elevated lipid levels, for monitoring the effectiveness of lipid lowering treatments, and, when used together they can determine Apo B/Apo A-I ratio as an alternative to total cholesterol/HDL cholesterol ratio when determining CVD risk

Emerging risk factors are also largely beneficial when assessing a patient’s risk of CVD. Our emerging risk factor panel consists of the following tests:

  • Lipoprotein(a) for consideration of Lp(a) levels in the risk assessment of CVD; elevated levels are associated with premature development of atherosclerosis and CVD, and are independent of other lipids. Lp(a) is genetically determined and unaffected by lifestyle changes and some treatments; testing for elevated levels is therefore recommended for patients with a family history of premature CVD or elevated Lp(a), and for patients who have developed CVD at a young age
  • sLDL Cholesterol, a subtype of LDL Cholesterol which is smaller in size enabling it to more readily permeate the inner arterial wall; elevated levels are associated with a three-fold increased risk of MI
  • Apolipoprotein A-II, a major constituent of HDL Cholesterol, plays an important role in reverse cholesterol transport and lipid metabolism; the production of Apo A-II levels determine the distribution of Apo A-I in HDL (Apo A-I removes excess cholesterol), and therefore increased production of Apo A-II promotes atherosclerosis
  • Apolipoprotein C-II, an aid in the assessment of CVD; Apo C-II deficiency can lead to hypertriglyceridemia (elevated triglyceride levels) in patients
  • Apolipoprotein C-III, an aid in CVD risk assessment with elevated levels associated with both primary and secondary hypertriglyceridemia, in addition to being reported higher in patients with type 2 diabetes, hyperbilirubinemia, kidney deficiency and decreased thyroid function
  • Apolipoprotein E, responsible for the transport of triglycerides to the liver and distribution of cholesterol between cells; deficiency can lead to premature atherosclerosis

For more information or to request informative materials for your laboratory please contact us, or alternatively download our cardiac brochure.

Randox offers enhanced testing of patient lipids with assays inclusive of not only conventional lipid assays such as Total Cholesterol, Triglycerides, HDL Cholesterol and LDL Cholesterol, but also extended lipid assays including Apolipoprotein A-I and Apolipoprotein B, and emerging risk factors such as Lipoprotein(a), sLDL Cholesterol, Apolipoprotein A-II, Apolipoprotein C-II, Apolipoprotein C-III and Apolipoprotein E.

Randox lipids profile is beneficial not only due to its extensity, but also as a result of the convenience and cost-effectiveness of our assays; our lipid assays offer…

  • Enhanced convenience with liquid ready-to-use reagents (Triglycerides kits also come in lyophilised form)
  • Cost effectiveness for even small throughput labs – all lipid assays are stable to expiry when stored at 2-8⁰C (except for Triglyceride kits, stable for 21 days when stored at 2-8⁰C or 3 days at 15-25⁰C)
  • Wide measuring ranges able to comfortably detect abnormal lipid levels
  • Applications for a wide range of clinical chemistry analysers
  • Excellent correlation to reference methods for security of accurate results
  • Controls and calibrators available including a 5 point calibrator for Lp(a) to account for the wide variation of different isoforms

To order your lipid kits please visit our online store or contact reagents@randox.com to get in touch with your local sales representative. Alternatively, contact us to request a kit insert, or refer to our individual product pages for more information.

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