Antioxidant Reagents

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Antioxidants are important for the body’s immune system and to protect the body against free radical attack. Randox provides a range of reagents to assess all three levels of the body’s defence system (preventative antioxidants, scavenging antioxidants and repair enzymes). Key tests include Total Antioxidant Status (TAS), Glutathione Peroxidase (Ransel), Superoxide Dismutase (Ransod) and Glutathione Reductase.

To discover more about our range of antioxidant assays select an assay from the drop-down menu below. Alternatively, to gain an understanding of the role of antioxidants and the relevancy of Randox antioxidant assays please read the sections below.

Antioxidant products available from Randox

Antioxidants defend our bodies from free radical damage!

As the body’s defence to free radicals, antioxidants are crucial in maintaining our health. Free radicals are highly reactive cells produced during the process of oxidation, a reaction which takes place during many of the body’s natural key processes such as respiration. Free radicals may also be produced when there is inflammation in the body, during exercise, and as a result of the body’s response to environmental factors such as sunlight and pollutants (chemicals, cigarette smoke etc.).

Antioxidants protect the body from free radical damage by inhibiting the formation of free radicals, destroying free radicals, or repairing damaged cells. The presence of antioxidants usually enables to body to handle free radicals, however if antioxidants are unavailable or if oxidative stress occurs, damage to the surrounding cells or tissue can occur. Oxidative stress refers to the imbalance between the production of free radicals and the body’s ability to detoxify them i.e. when there is an excessive production of free radicals. As a result free radicals have been implicated in many disease states.

Antioxidant benefits against disease…

Free radicals have been found to play a role in the development of many diseases including cancer (free radicals are thought to promote cell transformation into a cancer cell), arthritis and inflammatory diseases (increased oxidative stress in rheumatoid arthritis patients suggests antioxidants could have an important role), cardiovascular disease (antioxidants have been found to improve cardiac health), and Alzheimer’s disease (antioxidants have a role in removing deleterious free radicals from the brain).

How you can look after your body’s antioxidant defence…

The body’s antioxidant defence system is made up of antioxidants produced by the body naturally, in addition to requiring external sources to obtain antioxidants it cannot produce. The best source of antioxidants includes antioxidant rich foods. Foods high in antioxidants include fruits, vegetables and grains. The body’s natural antioxidant production declines with age, and therefore an antioxidant rich diet is important to ensure a healthy you!

Test your antioxidant health!

Your body’s antioxidant defence system can be tested with a simple blood test, just ask your doctor! Some of the tests to ask for include:

  • Total Antioxidant Status (TAS) for a general measurement of your antioxidant levels
  • Glutathione Peroxidase to test your selenium levels – low selenium levels can cause low immunity, constant fatigue and reproductive problems
  • Superoxide Dismutase – superoxide is one of the most common free radicals which plays a major role in the ageing process by damaging cells in your body

Antioxidants are important for patient health!

Antioxidants defend the body against free radical damage. Free radicals are highly reactive cells produced during the process of oxidation, a reaction required for many of the body’s natural key processes i.e. respiration. They are also produced as a result of the body’s response to viruses and bacteria as well as environmental pollutants, when there is inflammation in the body, and during exercise.

Antioxidant defence enables the body to handle free radicals, however in cases of oxidative stress damage to surrounding cells or tissue can occur. Oxidative stress is when there is an excessive production of free radicals resulting in an imbalance of free radicals to antioxidants; therefore antioxidant defence in the body becomes overwhelmed and the body’s ability to detoxify free radicals decreases. As a result free radicals, oxidative stress and the inflammation associated with it are the cause of most human disease including cancer, diabetes, cardiovascular disease, ageing and neurological disorders.

Antioxidants benefits therefore include a number of positive effects on the body such as helping to prevent diseases caused by oxidative stress, an improved immune system, and better skin.

Levels of antioxidant defence

The body has 3 levels of defence against free radical attack:

  • Preventative antioxidants to inhibit the formation of free radicals e.g. metal binding proteins like; Ceruloplasmin, Metallothionine, Albumin, Transferrin, Ferritin and Myoglobin
  • Scavenging antioxidants to remove any reactive species once formed. e.g. Superoxide Dismutase, Glutathione Peroxidase, Catalase and small molecules such as Ascorbate, Tocopherol, Bilirubin, Uric Acid, Carotenoids and Flavonoids
  • Repair enzymes to repair damaged biomolecules e.g. DNA repair enzymes

It is crucial to a patient’s health that a combination of these antioxidants be found circulating their body to defend against free radicals and oxidative stress.

You can help by testing patient antioxidant health!

A patient’s antioxidant health can be tested with a simple blood test, simply ask your laboratory!

  • For a general overview of the antioxidants in a patient’s body ask for a Total Antioxidant Status (TAS) test
  • To ensure a patient has the correct antioxidants required to protect the body from oxidative damage, and destroy free radicals that have formed in the body, ask for the Glutathione Peroxidase (Ransel) test to accurately measure their selenium levels – if this level is too low it can cause a loss of protection against serious illness, and if they are too high they can be toxic to a patient
  • To measure a patients level of superoxide (a free radical which plays a vital role in the ageing process) ask for a Superoxide Dismutase (Ransod) test
  • Other antioxidant tests include Glutathione Reductase, Albumin, Bilirubin, Ferritin, Total Iron Binding Capacity, Transferrin and Uric Acid

Testing patient antioxidant levels may help to prevent their risk of developing disease in addition to ensuring they have a good level of antioxidant defence required for any diseases they may have.

If you would like more information or require informative materials for your laboratory please contact us, or alternatively download our antioxidants brochure.

Randox range of antioxidant tests is suited to a variety of sectors including clinical, research, veterinary, pharma, food and beverages, cosmetics and sports. Our range of antioxidant assays includes routine assays such as Albumin, Bilirubin, Ceruloplasmin, Ferritin, Total Iron Binding Capacity, Transferrin and Uric Acid. In addition to routine antioxidant assays we have a range of specialised testing with products unique to Randox.

Our range of unique products include Total Antioxidant Status (TAS) to ensure accurate measurement of an individual’s general antioxidant health, Glutathione Peroxidase (Ransel) for accurate measurement of an individual’s selenium levels, Glutathione Reductase and Superoxide Dismutase (Ransod) to measure an individual’s superoxide levels.

Randox antioxidant assays are convenient and versatile with benefits including:

  • A range of liquid and lyophilised formats available
  • A variety of kits, methods and ranges available
  • Complementary controls and calibrators available
  • Suitable for a wide variety of sample types, including whole blood (human and animal), serum, plasma, erythrocytes, wine, beer and fruit juice
  • Suitable for automation – removing the inconvenience and time consumption associated with traditional ELISA based testing options
  • Applications available for an extensive range of clinical chemistry analysers and increased convenience with inclusion of detailed instrument specific settings

To order your antioxidant test kits visit our online store or contact reagents@randox.com to get in touch with your local sales representative. Alternatively, contact us to request a kit insert, or refer to our individual product pages for further information.

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